MESO-Rx Sponsor Primal Pharma - US Domestic

[Zebedee]

Whats beaker size got to do with anything?

Relationship to batch size

 

[Primal_Pharma]

Whats beaker size got to do with anything?

 

[Primal_Pharma]

https://thinksteroids.com/community/threads/primal-pharma-us-domestic.134430762/post-3542899

Can't immediately find dissolution batch sizes or if that question was ever posed. Good question.

No larger than 1L, we started with 2L, but the dosing accuracy isn't as tight.

 

[Photon]

https://thinksteroids.com/community/threads/primal-pharma-us-domestic.134430762/post-3542899

Can't immediately find dissolution batch sizes or if that question was ever posed. Good question.

His reply is for filtering, (I hope he's no longer using PVDF but has switched to PTFE by now but idc). I'd expect the whole batch to be brewed and then stored together post filter after tho. Unless he's switching out bottles post filter but I wouldn't expect it to matter much either.

Are we expecting large variance spikes from changing the filters from each brew?

 

[Zebedee]

No larger than 1L, we started with 2L, but the dosing accuracy isn't as tight.

So each of your batch numbers are only valid for just 100 vials, yeah?

 

[Primal_Pharma]

So each of your batch numbers are only valid for just 100 vials, yeah?

Technically no. In manufacturing, a batch isn’t defined by the number of vials or bottles, it’s defined by the process. A batch is a single, homogeneous production run created from one lot of raw material, processed under the same controlled parameters at the same time.

The number of vials that come out of that run depends on yield and fill volume, not on an arbitrary limit like 100. You could get 80 vials or 800, still one batch as long as it’s from that same homogeneous mixture.

 

[Talmad]

Stop being pussies… I remember back in the day, you’d be lucky if your shit didn’t have hairs and fucking dirt in it. This new peptide pansie era is testing everything… You probably test your Advil before a headache now too SMH.

Exactly what I have been thinking for a week with these guys! I take all them with floaters! Hell half them prob eat dam Taco Bell

 

[Photon]

Relationship to batch size

That's what I didn't get.
Brew all in the same beaker, filter into a 5l media bottle?

 

[Ghoul]

Exactly what I have been thinking for a week with these guys! I take all them with floaters! Hell half them prob eat dam Taco Bell

Definately sounds like some of you guys “take all comers” for sure…

 

[Zebedee]

Technically no. In manufacturing, a batch isn’t defined by the number of vials or bottles, it’s defined by the process. A batch is a single, homogeneous production run created from one lot of raw material, processed under the same controlled parameters at the same time.

The number of vials that come out of that run depends on yield and fill volume, not on an arbitrary limit like 100. You could get 80 vials or 800, still one batch as long as it’s from that same homogeneous mixture.

That's what I didn't get.
Brew all in the same beaker, filter into a 5l media bottle?

Yes, that’s one way of doing it & would equate to a single batch - assuming he has a 5L media bottle & can prove it - @Primal_Pharma

 

[readalot]

still one batch as long as it’s from that same homogeneous mixture.

Thank you. So you have cleared up that question. HPLC test result for a batch number should be representative for every vial in that batch since it is a common mixing pot with homogeneous solution (Cavg). Appreciate the definition.

What is the typical liquid volume for a given batch (mix/max/mean) if you don't mind?

 

[readalot]

His reply is for filtering, (I hope he's no longer using PVDF but has switched to PTFE by now but idc). I'd expect the whole batch to be brewed and then stored together post filter after tho. Unless he's switching out bottles post filter but I wouldn't expect it to matter much either.

Are we expecting large variance spikes from changing the filters from each brew?

See my wording above. I said dissolution batch size.

 

[Photon]

See my wording above. I said dissolution batch size.

Yea i missed out on that, by bad.
(I think it depends on what he's brewing imo -- raws availability mostly)

 

[Talmad]

Definately sounds like some of you guys “take all comers” for sure…

I injected oils from Mexico in 1988 and didn’t die! Came wrapped up in a magazine with rubber bands wrapping it together. I have down far worse!

 

[Talmad]

Definately sounds like some of you guys “take all comers” for sure…

I injected oils from Mexico in 1988 and didn’t die! Came wrapped up in a magazine with rubber bands wrapping it together. I have down far worse!

 

[M0USE]

Okay I’ll bite

 

[readalot]

Yea i missed out on that, by bad.
(I think it depends on what he's brewing imo -- raws availability mostly)

Could have 5 one liter "batches" thrown in one pot or just one 5 liter pot. What we are trying to determine is mix/max/mean batch volumes for a given batch number that share a common API concentration. (Each vial in that batch shares common concentration since it came from same solution).

 

[newguy2]

If your average is gtg then all vials are gtg. If your average is not then mix all in a 100ml vial and dispense to smaller vials, to get the average.

I'm probably missing something but couldn't the overall average look good but still have one hot or under-dosed vial? Just seems inaccurate.

 

[Mastedon]

You're a hero. Are the batches?:

Mast P200 - 001/P10? - Edit: Op Confirmed it's P11
NPP200 - P11? If so, your test is the first jano of this batch that i've seen

NPP200 = P10

 

[Whistles77]

NPP200 = P10

For reference @TallandSmall also tested NPP200 P10 and aligns with your result Janoshik Analytical

Don’t think there’s any P11 NPP testing yet