Pita / Zetia / Vascepa vs test / tren / mast / var (bloodwork)

[shredded.lyfe]

Thanks my friend. Yes lipo a was <10 , apo b high at 1.14 though with total and ldl fairly elevated. Plan is to stick on simvastatin and repatha (no pitavastatin approval in Canada yet)

I managed to get pitavastatin approved in Australia but of course not a single fucking retailer or warehouse stocks it in the entire country.

Black market wins again.

 

[Ariesstar80]

There’s so much anti-statin paranoia out there (including me for a long time), getting people to take anything to lower LDL has been a huge battle, so non-statin meds like Eze, Bemp, and PCSK9 (like Repatha) have been thought to be “the holy grail” of cardiology to finally get people to treat ldl down into a safe range.

The problem is all the studies show statins used as a base with any of those other meds do significantly more to lower risk than just the ldl reduction accounts for. It’s down to the anti-inflammatory effect. (It may be the cholesterol crystal dissolving property of statins responsible for much of that, less injury to the arteries from all that stabbing).

Without a statin, Eze and Bemp look weak on their own. (Better than nothing, just much much more effective as add ons to statins).

You’re single handily stopping that paranoia for all the peps on here. Do you have a background in research/science ? You’d be an amazing medical rep. I’m thinking of taking these pharmaceuticals as a preventive cardiology stack even though all my markers are in the green lol

 

[RockyP]

You’re single handily stopping that paranoia for all the peps on here. Do you have a background in research/science ? You’d be an amazing medical rep. I’m thinking of taking these pharmaceuticals as a preventive cardiology stack even though all my markers are in the green lol

In my former life I learned really quickly that some people who had boatloads of money were not only not smarter than everyone else, they were in fact rather stupid. The difference is, they knew the right people. They had others willing to help them, share information, and show them the ropes. This forum does have it's share of shit-talkers and trolls, but I can assure you that the information shared by @Ghoul and some other members will give you a far greater health benefit than interacting with the medical system in the standard manner. I've mentioned this before, I have a very well trained academic cardiologist (he's not a lipidologist, but he's not an idiot), and even he was hesitant to let me be "aggressive" with aiming to get my LDL under 50. I had to remind him of my family history of heart disease as well as a genetically low baseline HDL, which means that even without PEDs, I need to get my LDL as low as possible. While things like inflammation and oxidative stress are still very important (statins address this as well), I can't over-state how important this information is in terms of keeping PED users alive. The professional guys, at least in the Open class, will always have their health at greater risk just due to the fact that they bulk up to close to / over 300 lbs. Even with normal lipids and BP that is controlled with meds, being that big is a massive strain to the system. But for the rest of us, normal BP, low LDL, low AboB and Lp(a) - it doesn't guarantee anything, but it's the absolute best chance you have at CV longevity.

 

[Ariesstar80]

In my former life I learned really quickly that some people who had boatloads of money were not only not smarter than everyone else, they were in fact rather stupid. The difference is, they knew the right people. They had others willing to help them, share information, and show them the ropes. This forum does have it's share of shit-talkers and trolls, but I can assure you that the information shared by @Ghoul and some other members will give you a far greater health benefit than interacting with the medical system in the standard manner. I've mentioned this before, I have a very well trained academic cardiologist (he's not a lipidologist, but he's not an idiot), and even he was hesitant to let me be "aggressive" with aiming to get my LDL under 50. I had to remind him of my family history of heart disease as well as a genetically low baseline HDL, which means that even without PEDs, I need to get my LDL as low as possible. While things like inflammation and oxidative stress are still very important (statins address this as well), I can't over-state how important this information is in terms of keeping PED users alive. The professional guys, at least in the Open class, will always have their health at greater risk just due to the fact that they bulk up to close to / over 300 lbs. Even with normal lipids and BP that is controlled with meds, being that big is a massive strain to the system. But for the rest of us, normal BP, low LDL, low AboB and Lp(a) - it doesn't guarantee anything, but it's the absolute best chance you have at CV longevity.

What made him hesitant ? What were the cons to being aggressive with it ?

 

[RockyP]

What made him hesitant ? What were the cons to being aggressive with it ?

There's an outdated and (now we know) medically inaccurate paradigm that your LDL can be "too low" and lead to spontaneous hemorrhaging. This has been discredited.

LDL Cholesterol Lowering: Is There a Risk for Dementia and Hemorrhagic Stroke? - American College of Cardiology

www.acc.org

 

[just some dude]

That’s about all I recommend under normal circumstances. Its very potent, exceptionally effective against AAS induced high lipids, cheap (ish), easily accessible, no sides (overwhelmingly).

If you’re still >70, or aiming for regression and >40 add Bempadoic Acid.

For those with high lipids, absolutely can’t / won’t take a statin, or have years of untreated high cholesterol and want maximum possible regression + stabilization, or just willing to spend the cash for the very best cardiovascular protection, Repatha is an incredible 1 or 2x a month injection that’s ultra powerful. It has a very strong reputation for stopping future heart attacks and strokes.

It’s the only lipid med that reduces Lp(a), and it’s basically side effect free for the vast majority. It’s best combined with a statin if you can, to get the anti inflammatory effects only statins provide.

If you combine Pitavastatin 4, Ezetimibe, and Repatha, you’re using the most potent anti-cardiovascular disease combination science has available. 90%+ APO-b, LDL-C, 30% Lp(a), 60% HS-CRP (inflammation) reduction. Plaque will strongly regress over 18 months or so, whatever’s left will dry out and stabilize reducing risk even more over time.

I spoke to a cardiologist who told me if a patient has no symptoms, and they’re on this combo, he doesn’t even see a need for imaging, regardless of risk factors or 30 years of sky high cholesterol. “What difference would it make? This is the strongest risk reduction treatment a patient could be on, no matter how much plaque they have”. *

After a couple of years of this, even with a history of high cholesterol, if you also keep BP controlled, HS-CRP <1, and avoid diabetes, it’s plausible to have a 70%+ lower risk of heart attack, stroke, need a stent or bypass, vs a same age average peer.

*there is one other thing, anti-clot measures like asprin or other meds, that significantly adds to risk reduction, but this a complicated topic for a separate discussion

*salute

 

[just some dude]

There’s so much anti-statin paranoia out there (including me for a long time), getting people to take anything to lower LDL has been a huge battle, so non-statin meds like Eze, Bemp, and PCSK9 (like Repatha) have been thought to be “the holy grail” of cardiology to finally get people to treat ldl down into a safe range.

The problem is all the studies show statins used as a base with any of those other meds do significantly more to lower risk than just the ldl reduction accounts for. It’s down to the anti-inflammatory effect. (It may be the cholesterol crystal dissolving property of statins responsible for much of that, less injury to the arteries from all that stabbing).

Without a statin, Eze and Bemp look weak on their own. (Better than nothing, just much much more effective as add ons to statins).

Repatha + Eze + Bemp + Pita = Crush LDL

Started my first Repatha injection yesterday.