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This is a terrific source for nearly everything, but there are a handful of exceptions you shouldn’t buy overseas and “the super unstatin” is one. It must be shipped in a refrigerated pack, and if you’re in the US, Amgen cut a deal in response to the Trump admin’s request for “most favored nation pricing”, lowering the cash price from $700/mo to $239/mo. This is cheaper than the India wholesale price (cheapest in the world, in fact, in line with “most favored pricing”).

It includes refridgerated shipping. You can only get that price from from amgennow.com .

You’ll need a prescription, which can be gotten from your doc or telehealth for $29.

It was recently approved for “primary prevention”, meaning if you have LDL >70 and a single risk factor like being over 45, high blood pressure, or “family history” of early (<55) heart attacks (just have to say my mom/dad/uncles/etc had one) you qualify.

You can probably get insurance coverage with a little effort but even without, $239/mo is a good deal and only takes 5 mins with telehealth for a guaranteed prescription if you prefer.
Is repatha and ezetimibe the best combo? My hdl and ldl were both out of range in March.
I am down 40 pounds since march, and diet is clean as it will get for the last 3 months (chicken/salmon / veggie rice. No carbs since cutting)

I am doing alot of research to be more healthy, and statins is where I have zero knowledge.

I just got blood work today, and I am assuming my ldl and hdl will prolly still be out of range, so if that is the case, I am trying to figure out what the best meds are to take.
Or even if they are with in range, best hdl/ldl meds to have on hand for harsher cycles, so I stay healthier throughout them.
 
Is repatha and ezetimibe the best combo? My hdl and ldl were both out of range in March.
I am down 40 pounds since march, and diet is clean as it will get for the last 3 months (chicken/salmon / veggie rice. No carbs since cutting)

I am doing alot of research to be more healthy, and statins is where I have zero knowledge.

I just got blood work today, and I am assuming my ldl and hdl will prolly still be out of range, so if that is the case, I am trying to figure out what the best meds are to take.
Or even if they are with in range, best hdl/ldl meds to have on hand for harsher cycles, so I stay healthier throughout them.

The title of this document sums it up:

"LDL Cholesterol Management Simplified in Adults – Lower for Longer is Better: Guidance from the National Lipid Association"

Getting cholesterol as low as possible, for as long as possible.

The best lipid lowering protocol is the one that you’re willing to adhere to. It’s “time on target” that’s as important as absolute reduction. Because once you get it low enough to stop progression of plaque, the next goal is to minimize the damage already done. Low enough LDL will regress plaque. Literally pulling it back out of your arteries. But that’s only possible with the “freshest” plaque. Once that’s gone, the next benefit of very low LDL is to “suck” the inflammatory goo out of the plaque that’s not removable. That transforms the remaining plaque from unstable (likely to break off causing a heart attack), to dry, “mummified”, hardened plaque that’s still there but poses little risk.

We know from the huge, ongoing, long term Repatha studies, the first capable of achieving ultra low LDL, that there’s no “floor” level of these benefits, down to single digits. It’s also put to rest the theories of potential harms from ultra low LDL. Theres no indication whatsoever they exist.

The lower you get LDL the better off you’ll be. The limits are cost and what meds you can use without side effects becoming an issue.

Ideally, Repatha / Eze / Statin is the best stack, with the best results. But 2, or even 1 of any of them is significantly better than none.

On all three I’m down from 140 to 24.

Repatha and Eze are a potent combo, and great particularly for those fearful of statins who would otherwise let their high cholesterol go untreated. The only caveat is that inflammation is a major CVD (and general health) risk factor (makes “pimples” grow under plaque, which can make a piece more likely to break off and cause a heart attack). Statins have uniquely potent anti-inflammatory effects, 50% reduction of systemic inflammation, that other classes of lipid drugs don’t offer.
 
Last edited:
The title of this document sums it up:

"LDL Cholesterol Management Simplified in Adults – Lower for Longer is Better: Guidance from the National Lipid Association"

Getting cholesterol as low as possible, for as long as possible.

The best lipid lowering protocol is the one that you’re willing to adhere to. It’s “time on target” that’s as important as absolute reduction. Because once you get it low enough to stop progression of plaque, the next goal is to minimize the damage already done. Low enough LDL will regress plaque. Literally pulling it back out of your arteries. But that’s only possible with the “freshest” plaque. Once that’s gone, the next benefit of very low LDL is to “suck” the inflammatory goo out of the plaque that’s not removable. That transforms the remaining plaque from unstable (likely to break off causing a heart attack), to dry, “mummified”, hardened plaque that’s still there but poses little risk.

We know from the huge, ongoing, long term Repatha studies, the first capable of achieving ultra low LDL, that there’s no “floor” level of these benefits, down to single digits. It’s also put to rest the theories of potential harms from ultra low LDL. Theres no indication whatsoever they exist.

The lower you get LDL the better off you’ll be. The limits are cost and what meds you can use without side effects becoming an issue.

Ideally, Repatha / Eze / Statin is the best stack, with the best results. But 2, or even 1 of any of them is significantly better than none.

On all three I’m down from 140 to 24.

Repatha and Eze are a potent combo, and great particularly for those fearful of statins who would otherwise let their high cholesterol go untreated. The only caveat is that inflammation is a major CVD (and general health) risk factor (makes “pimples” grow under plaque, which can make a piece more likely to break off and cause a heart attack). Statins have uniquely potent anti-inflammatory effects, 50% reduction of systemic inflammation, that other classes of lipid drugs don’t offer.
Oh, I thought Repatha was a statin.

What statins do you suggest I look into? Any better than the others?
 
Oh, I thought Repatha was a statin.

What statins do you suggest I look into? Any better than the others?

As someone in the misfortunate 1% who had side effects from older statins, Pitavastatin, the latest generation of statin that only recently went from $500/mo to a cheap generic, is the one I recommend. It was formerly limited to people who desperately needed a statin but had side effects on others. It takes the already low risk of sides from modern statins and drops it even lower.

The minuscule doses compared to others hint at how tightly focused it is. That said. most people have no issues with Rosuvastatin, which is dirt cheap and easy to get.

One thing I’d recommend with any statin is a Coq10 supplement. All statins reduce Coq10 levels to a degree, Many people are already Coq10 deficient, and if it goes too low muscles can get sore and take longer to recover from a workout.

IMG_1924.webp
 
As someone in the misfortunate 1% who had side effects from older statins, Pitavastatin, the latest generation of statin that only recently went from $500/mo to a cheap generic, is the one I recommend. It was formerly limited to people who desperately needed a statin but had side effects on others. It takes the already low risk of sides from modern statins and drops it even lower.

The minuscule doses compared to others hint at how tightly focused it is. That said. most people have no issues with Rosuvastatin, which is dirt cheap and easy to get.

One thing I’d recommend with any statin is a Coq10 supplement. All statins reduce Coq10 levels to a degree, Many people are already Coq10 deficient, and if it goes too low muscles can get sore and take longer to recover from a workout.

View attachment 367180
Thank you, I really appreciate you. You just narrowed down my research tremendously in time.


Would you say 200mg daily of coq10 is a good amount or is it something you need to gauge off of bloodwork?
My daily multivitamin has 200mg.
 
Thank you, I really appreciate you. You just narrowed down my research tremendously in time.


Would you say 200mg daily of coq10 is a good amount or is it something you need to gauge off of bloodwork?
My daily multivitamin has 200mg.

Letting bloodwork guide you is really the best way. If you test coq10 levels after 2 weeks on the statin and it’s in range you’re fine.

If you prefer not to test, there’s no harm in taking 200mg daily. I recommend the ubiquinol form, ubiquinone is the cheaper oxidized form, which has to convert to the active form before it’s useful, and the ability to convert varies between people and declines with age. Ubiquinol is the easily absorbed active form that doesn’t have this issue.
 
Letting bloodwork guide you is really the best way. If you test coq10 levels after 2 weeks on the statin and it’s in range you’re fine.

If you prefer not to test, there’s no harm in taking 200mg daily. I recommend the ubiquinol form, ubiquinone is the cheaper oxidized form, which has to convert to the active form before it’s useful, and the ability to convert varies between people and declines with age. Ubiquinol is the easily absorbed active form that doesn’t have this issue.
We are so back boys. Cheap Indian pharma. Roids. Statins.

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This is a terrific source for nearly everything, but there are a handful of exceptions you shouldn’t buy overseas and “the super unstatin” is one. It must be shipped in a refrigerated pack, and if you’re in the US, Amgen cut a deal in response to the Trump admin’s request for “most favored nation pricing”, lowering the cash price from $700/mo to $239/mo. This is cheaper than the India wholesale price (cheapest in the world, in fact, in line with “most favored pricing”).

It includes refridgerated shipping. You can only get that price from from amgennow.com .

You’ll need a prescription, which can be gotten from your doc or telehealth for $29.

It was recently approved for “primary prevention”, meaning if you have LDL >70 and a single risk factor like being over 45, high blood pressure, or “family history” of early (<55) heart attacks (just have to say my mom/dad/uncles/etc had one) you qualify.

You can probably get insurance coverage with a little effort but even without, $239/mo is a good deal and only takes 5 mins with telehealth for a guaranteed prescription if you prefer.
Which medicine are you referring too? PCSK9 inhibitors?
 
Anyone running TESTENATE DEPOT 250MG? How are the results?
I am currently and I have been pretty much since I started ordering from PCT mid last year and it is good to go. I can bet he sells a butt load of it and I haven't as of yet heard anyone complain about them other than some preferred they used a different carrier oil.
 
I am currently and I have been pretty much since I started ordering from PCT mid last year and it is good to go. I can bet he sells a butt load of it and I haven't as of yet heard anyone complain about them other than some preferred they used a different carrier oil.
What is the carrier oil?
 

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