Ghoul
Member
I had been on Telm 80 / Amlodipine 5 (Valsartan 160/ Amlodipine 5 before that) for hypertension. Which brought me to roughly 125/78. Amlodipine 10 gave me better numbers but caused a little water retention.
After switching to Telm 40 / Cilnidipine 10 BP stayed the same, but quickly dropped a few pounds which I attributed to eliminating mild edema I hadn't noticed. The occasional annoying numb/cramp like sensation in a couple of toes that had been going on for years, especially during cold exposure, got much, much better. I attribute this to Cilnidipine's documented reduction in Reynaud's symptoms. ie, the exaggerated vasoconstriction of arterioles (tiny peripheral arteries) in response to norepinephrine from cold exposure or adrenaline.
I also noticed a 3 point reduction in RHR, again, because of Cilnidipine's blunting of sympathetic tone, where heart rate automatically increases in response to BP reduction.
I increased Ciln to 20mg since I had leeway to lower BP further and I wanted more of the ancillary benefits like the Reynaud's reduction, kidney protection, endothelial improvement, insulin sensitivity increase, and triglyceride reduction, that are independent of the BP reduction, and the fact there was virtually no risk of an increase in sides at that dose.
BP is now 117/75, RHR dropped by another point, triglycerides are down, kidney markers indicate improved function, and I have no Reynaud's symptoms at all. I also feel less of a physical response to stress, again, a documented impact of Ciln's unique N channel blocking reducing adrenaline's ability increase BP,
Since this is all stable, with no sides whatsoever (which is typical for ~85-90% at these doses), I plan to increase Telm to 80mg as that's the dose that's needed to get over the threshold of activating its PPAR effects, ie even greater insulin sensitivity, blood vessel inflammation reduction, increased baseline fat metabolism, and especially reversal of left ventricular remodeling (thinning walls out, reducing heart mass by as much as ~10% in 6 months and improved filling).
The only new caution at this dose is having to drop the potassium supplement and keeping an eye on levels, since Telm causes it to be retained and there's a very small risk of hyperkylemia if you're getting too much potassium from food.
Needless to say I'm very happy with Cilnidipine, and while I'd rather not have hypertension to treat at all (it's familial in my case), the fact I can deal with it and benefit from all the other positive longevity "side effects" from a once daily, tiny, single pill, side effect free combo makes me pretty satisfied I started down this path instead of accepting what the doctors were throwing at me.
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