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[Clappincheeks]

Any idea why?

You shot HGH in theory your blood sugar should drop IGF1 is release. 8 IUs is a large dose imo

 

[Sagnastymuscle]

You shot HGH in theory your blood sugar should drop IGF1 is release. 8 IUs is a large dose imo

I thought it was supposed to be the opposite unless one was insulin resistant? I guess I misunderstood

 

[Evom1]

I thought it was supposed to be the opposite unless one was insulin resistant? I guess I misunderstood

Very odd. Hgh raises mine

 

[Sagnastymuscle]

Very odd. Hgh raises mine

See I thought this was typically the norm aswell

 

[malfeasance]

Any idea why?

No, but here is what others who know more about it than me have to say.

Excess GH or GH administration in vivo are followed by an increase in circulating IGF-1 levels, therefore net effects of GH on glucose metabolism are complicated by IGF-1 effects. The receptors for IGF-1 and insulin are highly homologous in structure and biological function. Binding of the ligands results in autophosphorylation of the intracellular kinase domains and subsequent activation of downstream signaling cascades, which regulate gene transcription involved in substrate metabolism, cell growth and differentiation. IGF-1 and insulin strongly activate their respective receptors, but can also bind and weakly activate each other's receptors [18]. IGF-1 had caused a hypoglycemic effect in previous in vivostudies through stimulation of glucose uptake and gluconeogenesis, possibly either via activation of IGF-1 or via insulin receptors [19]. For example, administration of recombinant human IGF-1 to insulin receptor deficient mice induced insulin-mimetic effects, including both an increase in glucose uptake of skeletal muscle and a decrease in hepatic gluconeogenesis, through IGF-1 receptor activation. Consistent with this, IGF-1 infusion improved serum glucose levels in individuals with diabetes mellitus

Effects of growth hormone on glucose metabolism and insulin resistance in human - PMC

Growth hormone (GH) is important for promotion of somatic growth and the regulation of substrate metabolism. Metabolic action of GH occurs in multiple tissues including the liver, muscle, fat and pancreas either directly or indirectly through ...

pmc.ncbi.nlm.nih.gov

 

[Sagnastymuscle]

No, but here is what others who know more about it than me have to say.

Effects of growth hormone on glucose metabolism and insulin resistance in human - PMC

Growth hormone (GH) is important for promotion of somatic growth and the regulation of substrate metabolism. Metabolic action of GH occurs in multiple tissues including the liver, muscle, fat and pancreas either directly or indirectly through ...

pmc.ncbi.nlm.nih.gov

Thank you so much for this

 

[ackmack78]

Just curious if anyone has ever gone hypo after a bolus shot of Hgh? I took 8iu at like 3am last night and then went to lay down started feeling really funky got up to take a reading and I was at like 54.
Had ate my normal amount of food and everything.

Has never happened to me. You didn't accidentally take your insulin shot by any chance did you? Have heard of many bodybuilders getting those mixed up before bed.

 

[Sagnastymuscle]

Has never happened to me. You didn't accidentally take your insulin shot by any chance did you? Have heard of many bodybuilders getting those mixed up before bed.

Only insulin I have is in a pen and has never been touched or open, I’m not educated enough to use it properly so it won’t be touched until that point.
the only peptide vials I have are Hgh ,and igf1 lr3 and the lr3 vials are not open and are labeled the Hgh is in its own spot.
I’m 100% certain it was Hgh.
it’s a kit of the blue tops

 

[brutalbuilt]

I'm taking them now. Each vial is 32iu's and the purity was tested in the 98% to 99% range with no dimer. They're working great for me at 10iu/nightly and I might even be able to drop down to 8iu and get similar results.

is the vial big enough to reconstitute with 3ml water?

 

[brutalbuilt]

I thought it was supposed to be the opposite unless one was insulin resistant? I guess I misunderstood

gh increases blood sugar
igf1 lowers blood sugar

 

[Sagnastymuscle]

is the vial big enough to reconstitute with 3ml water?

I think they just barely fit 3ml I think I struggled to put 2.4ml in the old orange tops he had

 

[Clappincheeks]

I thought it was supposed to be the opposite unless one was insulin resistant? I guess I misunderstood

IGF-1 that’s released by your liver is one of the best-characterized effects of HGH activity. IGF-1 plays a critical role in preventing (inhibiting) the release of the HGH through a negative feedback loop by stimulating somatostatin and inhibiting GHRH release. However, HGH and IGF-1 secretion are regulated by each other, where HGH triggers IGF-1 release and the IGF-1 inhibits HGH release in a feedback loop. In healthy people, HGH release is inhibited by hyperglycemia (high blood sugar)and stimulated by sleep, stress, exercise, hypoglycemia (low blood sugar) and amino acids.

 

[CraneKraken]

is the vial big enough to reconstitute with 3ml water?

The vials are big enough. I usually go a little over to cover the final 2iu. I doubt they can take in much more though.

 

[OSEM]

Any ETA on a reopening, @Opti?

 

[Sagnastymuscle]

Any ETA on a reopening, @Opti?

I heard tward the end of this week/next in a different fourm

 

[Jtlittle88]

I heard tward the end of this week/next in a different fourm

Same here. Still would be nice to hear from em tho. Got my order today from what I placed a couple days before close

 

[Notcreative69]

Same here. Still would be nice to hear from em tho. Got my order today from what I placed a couple days before close

Still waiting on mine. I got an order complete before he closed. Heavent received anything since. Hoping it comes soon

 

[glpfun]

Still waiting on mine. I got an order complete before he closed. Heavent received anything since. Hoping it comes soon

Check your informed delivery

 

[Juiced_lizard]

Check your informed delivery

Not everyone has informed delivery.

 

[Jtlittle88]

Still waiting on mine. I got an order complete before he closed. Heavent received anything since. Hoping it comes soon

Just email him