I've placed several orders with Opti over the past month or so. Every time I do, I get both "Order Received" and "Order Complete" emails at the same time, which is whenever the btc payment gets at least 1 confirmation. After that, you won't receive any further communication or changes to the order status on the website. As with most domestic sources, there aren't any tracking numbers sent, which is for security reasons. If you haven't already, I would suggest signing up with the USPS for something called "Informed delivery" as it will notify you by email when a package sent to your address is entered into the system. I've received all of my orders from him in a timely manner, usually not more than 10 days, often less than that.
For GLP's, I've only ordered his Retatrutide, but I'm almost positive that every single one of his products ships from a location within the continental US, so yes, domestic.