Mushy's [Reta] Fat Loss Progress

[Mushy404]

ive looked at it again because i was like this cant be true


as you lose "bodyweight" you produce less t3, which is expected and what i said, you will burn less the less u weigh but this have nothing to do with dieting particularly and cant be avoided.


there was no change in t4>t3 conversion or free t4 or tsh

Can you given me that research please. I'd like to read it

 

[Mushy404]

Small Update:

In week 3 I gained 1.6 lbs, but this was absolutely not fat gain.
3 days prior I broke keto by bring my sister out for dinner and to the movies. I ate 7-8 French fries, the meat from the mixed grill, and then a large popcorn/Sugar soda. So absolutely not fat gain. The rest of the week was flawless.

As with breaking keto, there's water and glycogen reuptake - though I was surprised that the scales was still +1.6 lbs 3 full days later. Either way, I don't care and will absolutely be doing it again here and there over the next year.
I mentioned before (perhaps in a different thread) that a friend was flying over for 2 nights this weekend, and while he was here I would be eating carbs, eating more, and drink alcohol. So basically last Sunday, then Friday, Sat, and then again today Sunday, I ate more carbs, and had a moderate amount of alcohol. He's gone now and I will be glad to get back to business.

As with every time I break keto, I feel like crap. Parts of my body ache and I feel lethargic as hell! My cognition becomes sluggish too, so absolutely looking forward to getting on with things again.

I picked up some Tretinoin also - pretty good price, so happy to try that while I lose fat. If it doesn't help then it doesn't help. No harm and the cost means nothing to me.

So yeah, that's it! Back to the grind of life and will post the next update in 2 weeks or so when the scale has something to show. Peace!

 

[songsofpyramids]

You should be training yourself to limit breaking diet as much as possible, especially if you get such drastically negative impact. If you do break diet you should absolutely not be drinking soda unless it’s zero calories. I’d bet money that alone is what made you feel like shit and is the absolute last thing you should be putting in your body with your health.

Are you tracking calories? Now is the time you need to start focusing on healthy habits like that and maximizing protein intake. You cannot rely on the drugs alone to break your habits.

 

[Mushy404]

You should be training yourself to limit breaking diet as much as possible, especially if you get such drastically negative impact. If you do break diet you should absolutely not be drinking soda unless it’s zero calories. I’d bet money that alone is what made you feel like shit and is the absolute last thing you should be putting in your body with your health.

Are you tracking calories? Now is the time you need to start focusing on healthy habits like that and maximizing protein intake. You cannot rely on the drugs alone to break your habits.

The sugary soda was a peculiar one as I rarely drink soda at all, never mind that sugary shite. Even when I was binging on food over the last few years, I rarely drank sodas. Water and tea is essentially the only fluids I drink. I love coffee, but only have that as a treat every few weeks, but at the cinema that night I switched off and just said "give me the same", not really thinking as I was chatting.

As I said, I'm not really fussed. It was what it was. If there are any more cinema trips between now and Christmas then I'm sure I'll pay more attention. I say Christmas as that's the next planed break from the diet.

No, I don't count calories consciously anymore, but did in the past. Now from experience I generally have a good idea what's in the food I eat. My diet since getting on Reta is basically OMAD keto, and some days I make a point of eating twice. I'll look to refine it as I lose more weight, but for now it works just fine. Being OMAD or 2 meals a day on Reta pretty much guarantees I don't over eat as I get full quickly.

Me being fat was never a misunderstanding of my food. I understand basic nutrition quite well and do not need any help with it. Though I do appreciate you helping.

 

[songsofpyramids]

Rooting for you man

 

[Earthworm Jim]

Now watching this thread. I love stories like yours. You're doing great man!

 

[Mushy404]

Now watching this thread. I love stories like yours. You're doing great man!

Cheers bud!

I'm due a weigh-in this evening so will update a few things once I do that. I have a few things to talk about.

PS: I love the name! I used to love Earthworm Jim when I was a kid! They don't make em like that anymore.

 

[Mushy404]

UPDATE: So this update is a little bigger as there's a few things to saying.

General Reta/Fat loss progress:
The Reta is still working well at 3 mg every 3 days (≈6 mg/week). I do notice a bit of increased appetite on injection days, but it’s not an issue—if anything, it helps me fit in a few extra calories, giving my body a short break from being in such a caloric deficit. Importantly, the food noise and urges I had before starting Reta haven’t returned in any meaningful way.

Looking back, I probably escalated to 6 mg/week a little too quickly. I was aiming for maximal glucagon effect, but I’ve since realised that chasing that isn’t as beneficial as I thought—it would just accelerate desensitisation and push me into higher doses sooner, and into an eventual point where taking a 1-2 month break to re-sensitize makes sense. My new approach is to adjust the dose only if appetite or food noise creeps back to the point where it interferes with progress, or if I’m no longer in a sufficient deficit.

Since I began July 16th (6 weeks ago) I have an average of 3.6 lbs loss on the scales per week (-21.8 lbs total). No need for update pics yet—I’m still carrying a lot of fat—but I’ll probably share some once I hit around 300 lbs (≈90 lbs down from my start weight).

Feeling unusually cold:
I’ve noticed I’m more sensitive to cool or cold temps lately. At first I suspected a thyroid issue, though I’m already on T4 (Hypothyroidism). It could still be a T4→T3 conversion problem, which I’ll be able to confirm with my blood results around September 20th. That said, it seems rapid fat loss can also cause this increased sensitivity. Not a major issue for me right now, just something I’ve picked up on, and if I my September bloods indicate that I need to adjust something, then we'll cross that bridge then.

TRT, AI & E2:
I’ve been reading more into TRT, estradiol (E2), and the anastrozole my clinic prescribed. I’m not a fan of being on extra meds long-term—though I’ll take them if I have to. That brings me to the anastrozole.

About a month ago, my E2 came back at 52 pmol/L, which is the low end of normal. At that time I was dosing 0.25 mg every 3 days. I decided to stop it for about 1.5 weeks to let my levels rise closer to the mid-to-upper range. I then restarted the AI at 0.25 mg once weekly, mainly because I’m about a month out from bloodwork and wanted to be on a steady, consistent dose long enough to ensure accurate results. NOTE: Around the mid point of that 1.5-week break, I developed an almost insatiable libido (Borat voice: “High five! Very nice!”), however, that’s calmed down again—perhaps because of the hormonal fluctuations, or the carbs I had a few days prior. I'll bring in a few carbs again in a few weeks - so will report back on whether I notice a period of higher libido in the week following it.

I’ve also shifted to injecting testosterone cypionate every other day (EOD) instead of every 3 days. Smaller, more frequent doses should help keep hormone levels—and E2—more stable. My long-term aim is to need anastrozole only occasionally, and ideally not at all. But given my current body fat and the aromatisation that comes with it, I accept it may take some time before I can phase it out completely.

At the moment, my protocol is 98 mg of Test Cyp per week (200 mg/mL, 14 IU EOD using a 1 mL syringe). For now, I’m focused on finding a reasonable balance: enough testosterone to get the benefits without overshooting and driving up estrogen unnecessarily. Once I’ve dropped more fat and reduced aromatisation, I’ll look at adjusting upwards with the goal of full optimisation.

Miscellaneous:
Not a lot to report here, but will give it an honourable mention as it's something that I will update on later - I have ordered some Pregnenolone to try. I've been reading that there is a reasonable possibility that I might be deficient here since I have multiple other hormone issues. Going to try 50mg/day to see if I notice any cognitive or quality of life improvements.

I have been really trying to improve my sleep too as I've had chronically bad sleep for a while now and it's quite harmful. Of course losing weight has helped a little (breathing) and I am waiting on a sleep apnoea referral, so will continue to pull on that thread to see where I get. Yesterday I began a plan of regular melatonin use to improve sleep - apparently there's other benefits to it too, but my main aim is improving sleep.

I'm a few weeks into Tesamorelin/Ipamorelin - Stacked together at 10:30pm before bed (Tesa 2mg/Ipa 300mcg) and then Ipa again in the morning (300mcg). My natural IGF-1 levels are low, so the aim here generally is to increase my natural GH pulses which I am hoping will improve my sleep, but also hoping to speed up this bad shoulder I have. I sleep on my side, mainly on my left, and as a result my left shoulder is wrecked! Been sore over a year but is pretty bad now. I struggle to lift my arm up high, never mind trying to lift weights!

I have 25 more days of Tesa, so will make a decision closer to the time, but if my shoulder is still wrecked then I am strongly considering GH, TB500 and BPC 157 - not decided yet, but when the time comes I will have advanced blood work to inform my decision.

I think that's it for now. Feel free to comment with any constructive thought's/suggestions/questions.

 

[burner18]

I started taking reta (2mg/week) around the same time you did, and it's been great. I'm currently dosing 5mg/E3D without any terrible side effects. However, the one thing I've noticed, and maybe it's just me, but my skin sometimes feels overly sensitive. It's nothing terrible, but it's just...weird.

For sleep, I was taking melatonin and it works well enough, but I read somewhere that Glycine and Inositol help with reaching a 'deeper' sleep, so I gave it a try. So far so good. I usually take 3g Glycine and 1g inositol about 30 minutes before bed.


Thanks for sharing your journey - keep it up!!

 

[Mushy404]

I started taking reta (2mg/week) around the same time you did, and it's been great. I'm currently dosing 5mg/E3D without any terrible side effects. However, the one thing I've noticed, and maybe it's just me, but my skin sometimes feels overly sensitive. It's nothing terrible, but it's just...weird.

For sleep, I was taking melatonin and it works well enough, but I read somewhere that Glycine and Inositol help with reaching a 'deeper' sleep, so I gave it a try. So far so good. I usually take 3g Glycine and 1g inositol about 30 minutes before bed.


Thanks for sharing your journey - keep it up!!

Glad to hear you are doing well my friend!

Ive heard about skin sensitivity from some Reta users but I don't believe I have experienced this. I was getting very cold in a room where nobody else was (office) - though I put this down to rapid weigh loss, with potential for it being a thyroid thing.

I'm been experimenting with higher dose Melatonin - took 15-20mg at night recently. I dont know how people take double this... I was groggy AF haha. I'm going to keep going though. I've started taking Glycine recently too - Which ironically I have only taken in the AM as I keep forgetting to take it in the PM Will definitely look into inositol - never heard of it before.

 

[Mushy404]

Month 2 Update:

Ok... so...
Just jumped on a scales before sitting down to write this. Down a few more lbs to bring me to a grand total of -32lbs in 9 weeks. That's an average of 3.5lbs per week, which is a lot! I can't see 3.5lbs/week continuing much longer as I lose more weight, and in terms of minimising lose skin, it probably is a bit much to consistently lose each week - but I am not going to take my foot off the pedal either. I am focused.

I feel great compared to how I used to but still a lot of room for improvement. Libido still isnt great but I have noticed a little pick up here and there. Unsure why exactly, but it is only a month since I moved from E3D Test Cyp injections to EOD and pushed my Anastrazole out to E7D instead of E5D where I was for a short period. Prior to this I was E3D for the Anastrazole and got an E2 reading of 52pmol, which is too low. I have my advanced blood test Monday coming, so will post an update of those when I get them and we can compare to the February advanced bloods (and May T/E2).

A thought I have on hold while waiting on the bloods is regarding adding Proviron to help with libido. There seems to something to this, so willing to give it a try unless my bloods give me reason to pivot and try something else.

My Tesamorelin is days away from depletion and my shoulder is still wanked, so I have picked up some BPC 157, TB500, and GH to throw the kitchen sink at it. I am also adding Tadalafil 5-10mg per day too, but this is multi-factorial. Mainly it's for the sexual side of things, but it also lowers BP a little. Tadalafil is a PDE5 inhibitor that increases nitric oxide (NO) signalling, which relaxes blood vessels and enhances blood flow.

Talking of BP, I have spoken to my GP regarding a switch from Losartan BP meds (ARB) to Candisartan (ARB). I have an appointment with him regarding something else on Monday but sounds like we'll soon be switching BP meds. The Losartan's half life is not enough to cover me 24hr, whereas Candisartan will. I wanted Telmisartan as it has metabolic benefits also, but due to cost the UK NHS said no bueno! Which is fine... Candisartan is a great compromise.

My current BP when the Losartan is at its highest is about 125/70, which isnt acutely dangerous, but Losartan isnt covering me 24hrs and I find my BP up around 135-155 systolic, so chronically speaking is going to lead to renal issues quicker than a systolic of 110 for example. In fact, 110 is the systolic I am aiming for.

I will be starting the GH, TB500 and BPC next week - I might even start the TB500 and BPC tonight. Just waiting to use up the remained of the Tesa before switching to GH.

Feel free to ask any questions, or provide constructive criticism. I will finish this update post off with copy and pasting my profile which I have been tweaking with ChatGPT - so forgive any formatting quirks.


Current Health Protocol (as of mid-September 2025)
Context: Male, on TRT, hypothyroid, hypertensive, ketogenic OMAD diet, prioritising fat loss, skin tightening, tendon repair, and cognitive performance.

Prescription Medications
Levothyroxine — 150 mcg every morning
Losartan — 100 mg every morning (soon switching to Candisartan)
Apixaban — 2.5 mg AM + 2.5 mg PM

Hormones / Peptides (Active)
Testosterone cypionate (TRT) — 14 IU EOD = 28 mg/inj → ~98 mg/week
Dosing time: ~8:00 PM on EOD days
Anastrozole — 0.25 mg every 7 days (e.g., Thursday PM)
Tesamorelin — 2 mg nightly (~10:30 PM, empty stomach ≥2 h after food, ≥1 h after supps)
Ipamorelin — 300 mcg AM + 300 mcg PM (PM dose paired with Tesamorelin)
Pregnenolone — 50 mg daily

Core Supplements
AM (with tea or during fast)
Complete Multivitamin Complex™ — 1 tab
Super Strength Omega-3 — 3 caps (EPA ~990 mg, DHA ~660 mg)
Vitamin C — 1000 mg
Vitamin D3 — 4000 IU
Diosmin complex — 500 mg
Zinc — 25 mg (½ tab)
Magnesium bisglycinate — 2 tabs (400 mg elemental Mg)
Potasium Citrate - 400mg
Creatine monohydrate — 3.5 g
L-Arginine — 3 g
Methylene Blue — liquid (Mon–Fri, titrate until urine slightly blue)
Electrolyte powder — 2 g (if needed)

PM (with main meal, ~7:30–8:30 PM)
Complete Multivitamin Complex™ — 1 tab
Super Strength Omega-3 — 3 caps (EPA ~990 mg, DHA ~660 mg)
Garlic extract — 1000 mg
Diosmin complex — 500 mg
Magnesium bisglycinate — 1 tab (200 mg elemental Mg)
Electrolyte powder — 2 g (if needed)

Bedtime (~9:30–10:30 PM)
Magnesium bisglycinate — 1 tab (200 mg elemental Mg)
Glycine — 3–5 g (in warm water or tea)
Melatonin — ~10 mg (Natrol Time-Release 5 mg x2 or equivalent)
Tesamorelin + Ipamorelin — ~10:30 PM injection, subQ (no calories after)
→ Magnesium total: 4 tablets = 800 mg elemental Mg/day

Diet / Meal Plan
Ketogenic — always
OMAD ~80% of days, 2 keto meals ~20%
Main Meal (PM) — ~7:30–8:30 PM, includes PM multivitamin, garlic, omega-3, electrolytes
Morning tea with milk — retained (autophagy trade-off accepted)

Skin / Healing
Tretinoin 0.05% cream — 1×/week on lower abdomen (skin tightening)

Planned (Not Active Yet) — Shoulder Healing 4-Stack (8–10 Weeks)
Exogenous HGH — 2–3 IU nightly, subQ before bed
TB-500:
Weeks 1–4: 6 mg/week (split 3×/week)
Weeks 5–8 (or 10): 3 mg/week (split 2×/week)
BPC-157 — 500 mcg nightly (subQ near shoulder)
Cialis (Tadalafil) — 5 mg nightly (taken with PM supplements)

 

[Mushy404]

I started taking reta (2mg/week) around the same time you did, and it's been great. I'm currently dosing 5mg/E3D without any terrible side effects.

I meant to ask, why are you on 5mg/E3D already? Was there a resistance issue?

I am still on 3mg E3D but going by how my body feels I may be increasing this to 4mg E3D in the next 2 weeks - maybe

 

[burner18]

I meant to ask, why are you on 5mg/E3D already? Was there a resistance issue?

I am still on 3mg E3D but going by how my body feels I may be increasing this to 4mg E3D in the next 2 weeks - maybe

Resistance is part of it - the other part is the GERD I would get from a single higher dose. And I should have been more clear from my earlier post - this is my first week (and first dose) at 5mg/E3D - tomorrow's the next dose. I plan to re-evaluate after this week.

 

[Mushy404]

Resistance is part of it - the other part is the GERD I would get from a single higher dose. And I should have been more clear from my earlier post - this is my first week (and first dose) at 5mg/E3D - tomorrow's the next dose. I plan to re-evaluate after this week.

It was less a questioning of the frequency and more questioning the dose - obviously you are entitled to do what you want. I am asking out of curiosity.

But if we both started at 2mg/week around the same time, then you seem to have ramped up quite quickly if you are now taking 10mg/week (5mg E3D) v my 6mg/week (3mg E3D).

Just wondering if you had a particular reason for doing so?
From my understanding, apart from the Glucagon aspect of Reta, increasing the dose doesn't really burn more fat - the increase in calorie burning from increasing the Glucagon effect is not significant.

But if you are saying that resistance is a factor, then perhaps I am just a bit more sensitive than you and can get away with less for longer, while keeping the same level of appetite suppression.

For me, I want to drag out each dose so that it takes me longer to get to whatever my max dose is. Once I reach that and it ceases to be effective (likely 10mg per week), then I plan to take a 1-2 month break from Reta so I can re-sensitize to it and get effective results from a lower amount again.

Been considering picking up some Tesofensine for this "Reta-Break" in case I need appetite suppression while taking a break. Though, I am hoping to have established more willpower by then and wont need to rely on the Tesofensine much. E2D/E3D as opposed to ED.

 

[Mushy404]

Ok, I have received my blood results from earlier this week.

I have included the figures from my February bloods so we can see the trend.
NOTE: July E2/T ONLY included also.


(sampled 22/09, processed 23/09)

---

Proteins​

• Total Protein: 73 g/L (60–80) (Feb: n/a)
• Albumin: 45 g/L (35–50) (Feb: 43.9)
• Globulin: 28 g/L (19–35) (Feb: n/a)
• SHBG: 14.2 nmol/L (18.3–54.1) (Feb: 15.5)

---

Lipids (keto/weight-loss context)​

• Total Cholesterol: 5.54 mmol/L (<5.0) (Feb: 6.15)
• LDL-C: 3.96 mmol/L (<3.0) (Feb: 5.14)
• Non-HDL-C: 4.83 mmol/L (<4.0) (Feb: n/a)
• HDL-C: 0.71 mmol/L (>1.0) (Feb: 0.87)
• Triglycerides: 1.92 mmol/L (<2.3; fasting optimal <1.8) (Feb: 1.51)
• TC:HDL ratio: 7.8 (<6.0) (Feb: ~7.1)

Context: Since Feb, total cholesterol and LDL are down, HDL dropped further, triglycerides up slightly, and ratio worsened — typical keto/fat loss pattern.

---

Iron​

• Ferritin: 237 µg/L (30–442) (Feb: 109)

---

Thyroid​

• TSH: 2.38 mIU/L (0.27–4.2) (Feb: 1.66)
• Free T3: 4.8 pmol/L (3.1–6.8) (Feb: n/a)
• Free T4: 18.5 pmol/L (12–22) (Feb: 17.1)

---

Kidney​

• Urea: 5.9 mmol/L (2.5–7.8) (Feb: 4.89)
• Creatinine: 92 µmol/L (60–120) (Feb: 63)
• eGFR: 90 mL/min/1.73m² (≥60) (Feb: 121)

---

​

Glycaemic Control​

• HbA1c: 39 mmol/mol (20–42) (Feb: 41.8)

---

Hormones​

• FSH: 0.3 IU/L (1.5–12.4) (Feb: 0.43)
• LH: 0.3 IU/L (1.7–8.6) (Feb: 0.60)
• Oestradiol (E2): 167 pmol/L (41–159) (Feb: 231 / Jul: 52.2)
• Testosterone (total): 18.5 nmol/L (12–30) (Feb: 9.6 / Jul: 29.9)
• Free Testosterone (calc.): 0.546 nmol/L (0.198–0.619) (Feb: 0.266)
• Free Androgen Index: 130 % (35–92.6) (Feb: n/a)
• SHBG: 14.2 nmol/L (18.3–54.1) (Feb: 15.5)
• Prolactin: 369 mIU/L (86–324) (Feb: 259)
• PSA: 0.48 µg/L (<2.5) (Feb: 0.31)

---

Haematology​

• Haemoglobin: 160 g/L (130–180) (Feb: 157)
• Haematocrit: 0.489 L/L (0.40–0.52) (Feb: 0.471)
• RBC: 5.31 ×10¹²/L (4.4–6.5) (Feb: 5.14)
• WCC: 12 ×10⁹/L (3–11) (Feb: 9.2)
  
  • Neutrophils: 8.8 (2–7.5) (Feb: 6.6)
  • Lymphocytes: 2.3 (1.5–4.5) (Feb: 1.81)
  • Monocytes: 0.77 (0.2–0.8) (Feb: 0.56)
  • Eosinophils: 0.17 (0–0.4) (Feb: 0.21)
  • Basophils: 0.0 (0–0.1) (Feb: 0.03)
• Platelets: 324 ×10⁹/L (150–450) (Feb: 302)
• MCV: 92 fL (80–100) (Feb: 96.3)
• MCH: 30.1 pg (27–32) (Feb: 30.5)
• MCHC: 327 g/L (320–360) (Feb: 317)
• RDW: 14.6 % (11.5–15) (Feb: n/a)

---

Liver​

• Bilirubin: 8 µmol/L (<22) (Feb: 4.8)
• ALP: 112 U/L (30–130) (Feb: 92)
• ALT: 38 U/L (<45) (Feb: 30.6)
• GGT: 46 U/L (<55) (Feb: 37.5)

---

Key Trends​

• Testosterone: Feb low (9.6), peaked in Jul (29.9), now stabilised at 18.5 on current TRT protocol.
• E2: Feb very high (231), dropped sharply in Jul (52.2), now at 167 — slightly above male range but much improved from Feb.
• HbA1c: improved (41.8 → 39).
• Ferritin: doubled (109 → 237).
• Lipids: Total cholesterol & LDL down vs Feb; HDL lower, TG up, ratio worsened.
• Prolactin: rising (259 → 369).
• WCC/neutrophils: higher now (possible transient infection).
• Kidney eGFR: declined (121 → 90) but still normal.
• Liver enzymes: slightly higher than Feb, all safe.

 

[Mushy404]

All in all I am pleased with the direction I am going. Obviously there a lot of work still to do, but I am down from 391 July 16th, to 358 today.

Still having some libido issues, but isnt surprising considering the yo-yo'ing of my E2 levels. I am now moving from 0.25mg E7D to 0.25mg E5D, which I am guessing will put me around 120-130pmol Estradiol. I will be getting a finger prick E2/T test in 6 weeks and will update you then.

I will be switching from Losartan BP meds tomorrow, to Candasartan (unable to get a Telmisartan prescription unfortunately).

I am currently waiting to hear back from my TRT doc, with regards to getting some DHT cream to hopefully address the libido issue.

Current Protocol — Sept 2025 (active)​

Prescription Medications​

• Levothyroxine — 150 mcg daily
• Candesartan — 16 mg daily
• Apixaban — 2.5 mg AM + 2.5 mg PM (protein S deficiency)

---

Hormones / Peptides (active)​

• Testosterone cypionate (TRT)— 14 IU EOD = 28 mg per injection (200 mg/mL; 1 IU = 2 mg) → ~98 mg/week
  • Dosing time: ~8:00 PM EOD
• Anastrozole — 0.25 mg every 5 days
• Growth Hormone (GH) — 2–3 IU nightly, subQ before bed, empty stomach (replacing Tesamorelin + Ipamorelin, starting tonight)
• Pregnenolone — 50 mg daily
• TB-500 — 6 mg/week split 3×/week during weeks 1–4; then 3 mg/week split 2×/week during weeks 5–8/10
• BPC-157 — 500 mcg once daily, subQ before bed near the shoulder
• Cialis (tadalafil) — 5 mg nightly, taken with PM supplements

---

Core Supplements​

AM

• Complete Multivitamin Complex™ — 1 tab
• Super Strength Omega-3 — 3 caps (~990 mg EPA, ~660 mg DHA)
• Vitamin C — 1000 mg
• Vitamin D3 — 4000 IU
• Zinc — 25 mg (½ of 50 mg tab)
• Diosmin complex — 500 mg
• Magnesium bisglycinate — 1 tab (~200 mg elemental)
• Electrolyte powder — 2 g (as needed)
• Creatine monohydrate — 3.5 g
• L-Arginine — 3 g
• Potassium citrate — 400 mg
• Glycine — 3.2 g (4 scoops)
• Ground flaxseed — 15 g

PM (with main meal ~7:30–8:30 PM)

• Complete Multivitamin Complex™ — 1 tab
• Super Strength Omega-3 — 3 caps
• Garlic extract — 1000 mg
• Diosmin complex — 500 mg
• Magnesium bisglycinate — 1 tab (~200 mg elemental)
• Electrolyte powder — 2 g (as needed)
• Ground flaxseed — 15 g

Bedtime (~9:30–11:00 PM)

• Glycine — 3.2 g (4 scoops)
• Magnesium bisglycinate — 2 tab (~400 mg elemental)
• Melatonin — ~10 mg
• Creatine monohydrate — 3.3 g
• L-Arginine — 3 g
• GH injection (subQ, empty stomach, ≥2 h post-meal, ≥1 h post-supps)

---

Other Adjuncts​

• Methylene blue — liquid Mon–Fri, titrated until urine slightly blue
• Tretinoin 0.05% cream — 1×/week, abdomen (loose-skin focus)

---

Diet / Food​

• Always ketogenic
• OMAD ~80% of days; 2 keto meals ~20%

 

[Sera]

All in all I am pleased with the direction I am going. Obviously there a lot of work still to do, but I am down from 391 July 16th, to 358 today.

Still having some libido issues, but isnt surprising considering the yo-yo'ing of my E2 levels. I am now moving from 0.25mg E7D to 0.25mg E5D, which I am guessing will put me around 120-130pmol Estradiol. I will be getting a finger prick E2/T test in 6 weeks and will update you then.

I will be switching from Losartan BP meds tomorrow, to Candasartan (unable to get a Telmisartan prescription unfortunately).

I am currently waiting to hear back from my TRT doc, with regards to getting some DHT cream to hopefully address the libido issue.

Current Protocol — Sept 2025 (active)​

Prescription Medications​

• Levothyroxine — 150 mcg daily
• Candesartan — 16 mg daily
• Apixaban — 2.5 mg AM + 2.5 mg PM (protein S deficiency)

---

Hormones / Peptides (active)​

• Testosterone cypionate (TRT)— 14 IU EOD = 28 mg per injection (200 mg/mL; 1 IU = 2 mg) → ~98 mg/week
  • Dosing time: ~8:00 PM EOD
• Anastrozole — 0.25 mg every 5 days
• Growth Hormone (GH) — 2–3 IU nightly, subQ before bed, empty stomach (replacing Tesamorelin + Ipamorelin, starting tonight)
• Pregnenolone — 50 mg daily
• TB-500 — 6 mg/week split 3×/week during weeks 1–4; then 3 mg/week split 2×/week during weeks 5–8/10
• BPC-157 — 500 mcg once daily, subQ before bed near the shoulder
• Cialis (tadalafil) — 5 mg nightly, taken with PM supplements

---

Core Supplements​

AM

• Complete Multivitamin Complex™ — 1 tab
• Super Strength Omega-3 — 3 caps (~990 mg EPA, ~660 mg DHA)
• Vitamin C — 1000 mg
• Vitamin D3 — 4000 IU
• Zinc — 25 mg (½ of 50 mg tab)
• Diosmin complex — 500 mg
• Magnesium bisglycinate — 1 tab (~200 mg elemental)
• Electrolyte powder — 2 g (as needed)
• Creatine monohydrate — 3.5 g
• L-Arginine — 3 g
• Potassium citrate — 400 mg
• Glycine — 3.2 g (4 scoops)
• Ground flaxseed — 15 g

PM (with main meal ~7:30–8:30 PM)

• Complete Multivitamin Complex™ — 1 tab
• Super Strength Omega-3 — 3 caps
• Garlic extract — 1000 mg
• Diosmin complex — 500 mg
• Magnesium bisglycinate — 1 tab (~200 mg elemental)
• Electrolyte powder — 2 g (as needed)
• Ground flaxseed — 15 g

Bedtime (~9:30–11:00 PM)

• Glycine — 3.2 g (4 scoops)
• Magnesium bisglycinate — 2 tab (~400 mg elemental)
• Melatonin — ~10 mg
• Creatine monohydrate — 3.3 g
• L-Arginine — 3 g
• GH injection (subQ, empty stomach, ≥2 h post-meal, ≥1 h post-supps)

---

Other Adjuncts​

• Methylene blue — liquid Mon–Fri, titrated until urine slightly blue
• Tretinoin 0.05% cream — 1×/week, abdomen (loose-skin focus)

---

Diet / Food​

• Always ketogenic
• OMAD ~80% of days; 2 keto meals ~20%

Just one thing I wanted to comment, I don’t think you can really take anastrozole every 5 days. Your e2 will be all over the place. It’s half life isn’t long enough for that. I personally take mine everyday. Kind of difficult to do unless you are able to get a pharmacy to make a custom strength though.

 

[Ateam2023]

Just one thing I wanted to comment, I don’t think you can really take anastrozole every 5 days. Your e2 will be all over the place. It’s half life isn’t long enough for that. I personally take mine everyday. Kind of difficult to do unless you are able to get a pharmacy to make a custom strength though.

i also take my dex on M/Thurs on injection days , you are absolutely correct about the e2 levels being to "uncontrolled" because of its half life

 

[Mushy404]

Just one thing I wanted to comment, I don’t think you can really take anastrozole every 5 days. Your e2 will be all over the place. It’s half life isn’t long enough for that. I personally take mine everyday. Kind of difficult to do unless you are able to get a pharmacy to make a custom strength though.

Thanks for raising this.

This is the conundrum I am in, because I am in the UK and from the bit of poking around I'd done, it's not that easy to get hold of compounded Anastrazole.

Full admission, I haven't looked very hard though haha. But now that I find myself in this position, I will address this better.

I am waiting to hear back from the main guy at my TRT clinic regarding getting some DHT cream prescription from him. They dont normally do it, but I have asked if I can get a UK licenced compounding pharmacy, would they provide a prescription that I can bring to them.

I will include anastrazole to when I get a response. I get the feeling he's going to decline the prescription for DHT /working with the compounding pharm - in which case I am going to try find a better clinic.

I have been quite moody since starting Anastrazole, sometimes worse than others. I guess this is what you get when your E2 is up and down like a lady of the night's knickers.

I'll provide an update when I have one.

 

[Sera]

Thanks for raising this.

This is the conundrum I am in, because I am in the UK and from the bit of poking around I'd done, it's not that easy to get hold of compounded Anastrazole.

Full admission, I haven't looked very hard though haha. But now that I find myself in this position, I will address this better.

I am waiting to hear back from the main guy at my TRT clinic regarding getting some DHT cream prescription from him. They dont normally do it, but I have asked if I can get a UK licenced compounding pharmacy, would they provide a prescription that I can bring to them.

I will include anastrazole to when I get a response. I get the feeling he's going to decline the prescription for DHT /working with the compounding pharm - in which case I am going to try find a better clinic.

I have been quite moody since starting Anastrazole, sometimes worse than others. I guess this is what you get when your E2 is up and down like a lady of the night's knickers.

I'll provide an update when I have one.

If you do happen to get an opportunity to get compounded anastrozole. I think 0.125mg tabs would be a good start. Then you can find your sweet spot a little easier. One tab every other day is more reasonable.