More tren = more fat loss? Tren's fat loss mechanism.

[demal]

Does more trenbolone = more fat lost, in a strict caloric deficit?

Recently I posted another thread - Recomping effects of tren possible at 100-120mg/w?
We know that the recomping & anticatabolic effects (Decreased PPARγ mRNA expression & decreased GR expression) of trenbolone are present even in lower dosages (<100mg weekly).

Obviously we know that more tren = more side effects. But let's set them aside for this discussion and focus purely on the benefits of tren.


So would increasing the dosages of trenbolone (for example 100mg vs 200mg) increase the fat loss during a caloric deficit (let's say a deficit of 1000 calories)? And what is the main mechanism for it?


Here is what I thought: Increasing the dosages beyond 50-100mg would lead to low benefits in terms of fat lost, as the main reason / mechanism someone would use trenbolone - is to decrease the amount of muscle lost during a deficit due to decreased GR expression (which lower dosages are enough for).

However, it also makes sense that increasing trenbolone would lead to more muscle retained -> higher amount of calories burnt. But is it significant? Let's say 75mg of tren a week would prevent 80-90% of muscle loss (just speculation numbers out of my head). Increasing the dosage to 150mg a week would prevent just a little bit more (like additional 5-10% - again, just speculation numbers to get my point accross) of muscle loss, which would be insignificant for faster fat loss.

I hear a lot of people saying that tren "directly burns fat", but I am not sure what they mean by it - is there a "hidden" direct fat loss mechanism I'm missing?


What do you guys think? What are your experiences?

 

[carbmaster]

I hear a lot of people saying that tren "directly burns fat", but I am not sure what they mean by it - is there a "hidden" direct fat loss mechanism I'm missing?


What do you guys think? What are your experiences?

I believe PPAR Gamma antagonism plays a role. @Type-IIx would know the most. His article is very good.

 

[demal]

I believe PPAR Gamma antagonism plays a role. @Type-IIx would know the most. His article is very good.

Also thought of that. However it seems that decreased PPAR Gamma shines in a caloric surplus, where it directly decreases adipogenesis (generation of new fat cells).

@Type-IIx 's article states "PPARγ is a peroxisome proliferator-activated receptor that controls the formation of new fat cells, fatty-acid uptake and storage, and therefore insulin sensitivity. [4]. Trenbolone decreases PPARγ mRNA expression during increased feeding."

 

[Deadpool99]

Does more trenbolone = more fat lost, in a strict caloric deficit?

Recently I posted another thread - Recomping effects of tren possible at 100-120mg/w?
We know that the recomping & anticatabolic effects (Decreased PPARγ mRNA expression & decreased GR expression) of trenbolone are present even in lower dosages (<100mg weekly).

Obviously we know that more tren = more side effects. But let's set them aside for this discussion and focus purely on the benefits of tren.


So would increasing the dosages of trenbolone (for example 100mg vs 200mg) increase the fat loss during a caloric deficit (let's say a deficit of 1000 calories)? And what is the main mechanism for it?


Here is what I thought: Increasing the dosages beyond 50-100mg would lead to low benefits in terms of fat lost, as the main reason / mechanism someone would use trenbolone - is to decrease the amount of muscle lost during a deficit due to decreased GR expression (which lower dosages are enough for).

However, it also makes sense that increasing trenbolone would lead to more muscle retained -> higher amount of calories burnt. But is it significant? Let's say 75mg of tren a week would prevent 80-90% of muscle loss (just speculation numbers out of my head). Increasing the dosage to 150mg a week would prevent just a little bit more (like additional 5-10% - again, just speculation numbers to get my point accross) of muscle loss, which would be insignificant for faster fat loss.

I hear a lot of people saying that tren "directly burns fat", but I am not sure what they mean by it - is there a "hidden" direct fat loss mechanism I'm missing?


What do you guys think? What are your experiences?

There is also the Mitochondrial uncoupling / oxidative metabolism trenbolone increases mitochondrial uncoupling proteins (UCPs), making energy production less efficient. “Less efficient” = you burn more calories as heat. This is a big part of why tren has a reputation for “running hot” and why night sweats are common.

Also tren’s anti-catabolic effect means higher rates of muscle protein synthesis/retention relative to breakdown. That constant turnover is energetically expensive compared to simply storing calories as fat.

Tren isn’t “burning fat directly” like clen/T3. It’s wasting energy (uncoupling + heat), redirecting nutrients into expensive pathways, and amping up adrenergic tone, which collectively raise TDEE compared to testosterone. That’s why people can sit in a deficit and get drier and leaner much faster on tren than on test.

 

[bananafeet]

It's spooky steroid magick that sends you loopy.

A mate of mine who raises cattles says they won't give the Tren pellets during summer or the cattle die from heat. Don't know if it's true or not

 

[BigDadd7]

There is also the Mitochondrial uncoupling / oxidative metabolism trenbolone increases mitochondrial uncoupling proteins (UCPs), making energy production less efficient. “Less efficient” = you burn more calories as heat. This is a big part of why tren has a reputation for “running hot” and why night sweats are common.

Also tren’s anti-catabolic effect means higher rates of muscle protein synthesis/retention relative to breakdown. That constant turnover is energetically expensive compared to simply storing calories as fat.

Tren isn’t “burning fat directly” like clen/T3. It’s wasting energy (uncoupling + heat), redirecting nutrients into expensive pathways, and amping up adrenergic tone, which collectively raise TDEE compared to testosterone. That’s why people can sit in a deficit and get drier and leaner much faster on tren than on test.

This gave me a little bit of a boner. Anecdotally, it's exactly what I have experienced when cutting on tren. Or possibly, only what I percieved as happening. Either way, I was pleased with the results.

 

[wp_375]

Sure would be nice if there wasn't basically zero clinical data on Tren in humans. LOL

Maybe one day we'll get lucky and someone will find and publish all the Negma human trial data they find in some old deceased Negma chemist's attic. Till then we basically have no straight answers on what this shit does in our body

 

[bananafeet]

Sure would be nice if there wasn't basically zero clinical data on Tren in humans. LOL

Maybe one day we'll get lucky and someone will find and publish all the Negma human trial data they find in some old deceased Negma chemist's attic. Till then we basically have no straight answers on what this shit does in our body

I think we know what it does without a scientific study of humans:
1. Raises thyroid production through HPTA interaction
2. Raises body temp
3. Raises protien synthesis and blocks catabolic pathways
4. Causes hypoglycemia by forcing protien sparing and nutrient partitioning
5. Disrupts sleep and causes plaque in the brain
6. Stresses organs due to oxidative stress
7. Increases libido and agression by crossing blood brain barrier and interacting with the brain

probably not a great drug long term lol

Type2x has some great articles on it

 

[explodingHeart]

You can just as easily take a GLP, walk on the treadmill and do low volume high intensity lifting 3x a week and getting shredded to the bone without any risk or stress to your body.

There's no need for harsh dieting drugs anymore with GLPs.

 

[RockyP]

You can just as easily take a GLP, walk on the treadmill and do low volume high intensity lifting 3x a week and getting shredded to the bone without any risk or stress to your body.

There's no need for harsh dieting drugs anymore with GLPs.

People will always want it faster. But you are correct. Tren is a cheat code that comes with a large price tag for some. Others are incredibly tolerant to it. But I’ve found that rushing these things when cutting or bulking doesn’t end well (for me). I’m as guilty as anyone for looking at my regimen on a very regular basis and saying hmmm should I add this, increase that, pull this for that, etc? When I find myself doing that i now know I need to focus even more on my diet as that will be the deciding factor in how big or lean I get.

 

[explodingHeart]

People will always want it faster. But you are correct. Tren is a cheat code that comes with a large price tag for some. Others are incredibly tolerant to it. But I’ve found that rushing these things when cutting or bulking doesn’t end well (for me). I’m as guilty as anyone for looking at my regimen on a very regular basis and saying hmmm should I add this, increase that, pull this for that, etc? When I find myself doing that i now know I need to focus even more on my diet as that will be the deciding factor in how big or lean I get.

If you need extremes to lose fat, you're probably too fat for PEDs or bodybuilding lifestyle in general, imo.

Competitors who actually place well are always within a 6-12 weeks max of contest shape.

 

[RockyP]

If you need extremes to lose fat, you're probably too fat for PEDs or bodybuilding lifestyle in general, imo.

Competitors who actually place well are always within a 6-12 weeks max of contest shape.

Yup. They never need extremes because they never get too fat. Lee priest notwithstanding

 

[explodingHeart]

Yup. They never need extremes because they never get too fat. Lee priest notwithstanding

I'll speculate more. If you go from like 20% to like 8% your skin looks kinda shitty and weird.

I'm not saying stretch marks, just that the massively long process to get there makes you look watery and weird.

It takes months / years at low BF to stay dry and for your body to get used being single digits. Just my opinion tho.

 

[RockyP]

I'll speculate more. If you go from like 20% to like 8% your skin looks kinda shitty and weird.

I'm not saying stretch marks, just that the massively long process to get there makes you look watery and weird.

It takes months / years at low BF to stay dry and for your body to get used being single digits. Just my opinion tho.

And what’s more, some bodies just aren’t wired to stay that low for any extended period of time. Even with androgens and GH it can be a dog fight.

 

[Banana Joe]

This is a week old. At least you made the effort to write an into. But it doesn't change the fact that you are a retard.

Hey, I am new here and currently making my first steps into the world of PED's.
Currently I'm on my first cycle of rad-140 and mk677 from DriadaMedical and I feel amazing. Started my journey by becoming a sarm goblin xD.

For fat loss I would try DNP, it gives you the aforementioned mitochondrial uncoupling in spades. The great thing about DNP is:

more DNP = more fat lost



Literally every fucking day. EVERY. even MULTIPLE ones.

 

[Earthworm Jim]

This is a week old. At least you made the effort to write an into. But it doesn't change the fact that you are a retard.



For fat loss I would try DNP, it gives you the aforementioned mitochondrial uncoupling in spades. The great thing about DNP is:

more DNP = more fat lost



Literally every fucking day. EVERY. even MULTIPLE ones.

You should just shut up instead of leaving jackass comments all over the place

 

[professionaldyel]

this whole anti catabolic thing with tren makes me smile. We are taking PEDs, they are all anti catabolic. 99% of us dont have enough tissue to the point we're going to lose more than a pound if that while dieting especially if you're a lifestyle guy. its just a silly way to rationalize drug abuse. Tren in prep as an amateur is for a specific look. Just take 250mg of dnp and get the results you want in 2 weeks.

 

[Banana Joe]

You should just shut up instead of leaving jackass comments all over the place

Looks like I struck a nerve. Let's investigate!

Yepp, check's out: registered 2025, 90+% of posts are in underground forum, too dumb to read rules.

Never made an intro and this is your very first post in "What did you inject today?":

GenLabs 120mg Test E and 70mg Tren E and about 1mg of reta

You're the very same kind of moron in whose threads I left "jackass comments all over the place". You gotta try harder next time.

 

[demal]

This is a week old. At least you made the effort to write an into. But it doesn't change the fact that you are a retard.



For fat loss I would try DNP, it gives you the aforementioned mitochondrial uncoupling in spades. The great thing about DNP is:

more DNP = more fat lost



Literally every fucking day. EVERY. even MULTIPLE ones.

You really dig into people's past posts (years old btw) to make some useless comments?

It seems that you cannot understand that people make mistakes, especially when it comes to PEDs and lack of knowledge when starting out.
Don't tell me you never saw members here (which are huge & well educated now) running prohormones only in the past or making other dumb mistakes.

So what value are you providing here, especially taking into consideration your previous comments?
Seems like none, if all you do is sitting on the forum and trying to offense everyone.

At least you mentioned DNP.

 

[Jesintn]

this whole anti catabolic thing with tren makes me smile. We are taking PEDs, they are all anti catabolic. 99% of us dont have enough tissue to the point we're going to lose more than a pound if that while dieting especially if you're a lifestyle guy. its just a silly way to rationalize drug abuse. Tren in prep as an amateur is for a specific look. Just take 250mg of dnp and get the results you want in 2 weeks.

Not anyone wants to sweat through their pillow case every night, and have sweat on upper body and hair, back of neck , soaked

Eod dnp causes enough of this, yet much more comfortable than ed

used tren for the first time yesterday 4-5 mgs ,since 2020 , when I tried 10 mgs one day and screamed at someone in the gym. Before that 2018, 150 mgs max dose for one month. 2017 50,75,100,150,150 at Junior nattys in chicago

Hair seemed to miniturize in 2018, and for those concerned about hair miniturization running tren or any androgenic, monitor closely, while using derma rolling, oils in hair that block dht, esp pumpkin seed oil, emu oil too. Ru58841 is worth a shot. ketonconazole 2 %, minox

Using tren for the major reason for fat loss is ignorant