More reta = more fat loss?

[Jason_orange12]

Is it as simple as that or not ive seen people saying they have taken more and they can “eat what they want” and lose fat and ive seen others say after the supression goes 15mg does no more than 8mg

What is your experience? If your getting zero appetite suppresion when you up it are you just burning your money?

 

[Elektrobot]

“eat what they want” and lose fat

............because what they want to eat is nothing

 

[iudex]

Whats the point in reta if its only 100-200 cal gain a day net but your hungrier

Tirz and Reta have the same binding affinities to both the Glp1 and GIp receptor. No reason to use tirz over Reta besides cost.

In my opinion, there's little upside to taking Reta over Tirz purely based on the numbers and effectiveness. In the trials people lost up to 22.5% with Tirz and up to 24% with Reta, however the dropout rate of Reta was higher as there appears to be more side effects. I think the key decision to be made wr.t. Sema Tirz or Reta is simply how well you tolerate it. Also as far as I am aware, confidence in Reta from a pharma standpoint is not as high as in the peptide bro social media bubble, it appears that they stick to Tirz and continue to research other agonist combinations (i.e. Cagri, ...).

 

[Athleticfreak]

In my opinion, there's little upside to taking Reta over Tirz purely based on the numbers and effectiveness. In the trials people lost up to 22.5% with Tirz and up to 24% with Reta, however the dropout rate of Reta was higher as there appears to be more side effects. I think the key decision to be made wr.t. Sema Tirz or Reta is simply how well you tolerate it. Also as far as I am aware, confidence in Reta from a pharma standpoint is not as high as in the peptide bro social media bubble, it appears that they stick to Tirz and continue to research other agonist combinations (i.e. Cagri, ...).

Much bigger percentage difference than you listed .

Tirz 20.9% phase 3 trials

Reta 28% in phase 3 trials

Reta is a Lambo compared to Tirz a Mustang, not even comparable.

 

[iudex]

Much bigger percentage difference than you listed .

Tirz 20.9% phase 3 trials

Reta 28% in phase 3 trials

Reta is a Lambo compared to Tirz a Mustang, not even comparable.

It is true that the percetage of weight loss for Reta was reported higher in the preliminary results of the phase 3 trial. But as far as I am aware, that trial has yet to be concluded so the final dataset and results are still pending. Regardless, the figure mentioned is for completers only. If you consider also the discontinuations, it drops to ~23.7% which is the figure I was reporting. I was specifically including discontinuations because those happened at a higher rate (~18% at higher dosages) compared to Tirzepatide. Tirzepatide appears to be a lot more tolerable across the tested dosages compared to Reta, taking this into account leads to similar amounts of weight loss.

 

[Rbvasques]

If you read the trials results of phase 2,
2mg to 4mg considerably more weight loss
4mg to 8mg decent
8mg to 12mg marginal

 

[BP_6]

Reta is just like any other drug. More reta=more fat loss. Higher dose is generally going to lead to more results. Just as 100mg of anadrol will give more muscle than 50mg. However as with all drugs, the benefits decrease as the dose increases and you reach a point where more drug stops really giving more results and is a waste and or more sides.

That amount from the actual studies, not bro science appears to be about 12mg at this moment. After 8mg, the gains really start to slow down.

I personally am of course keeping track of the anectdotal, however I do trust the actual real world carefully documented results the most.

 

[shredded.lyfe]

The amount of bioscience noobs on this forum piss me off lately.

Muscle sparing was better on reta (pure lipolysis)

Reta was shown to reduce fatty liver by 84% compared to Tirz achieving approximately 50% in the same timeframe.

Please don't stack tirz with reta you fkn morons, they fight for the same receptors and retas affinity for those receptors is significantly stronger than tirz, its not going to do what you think it's going to do.

Lastly if you need more than the max dose of reta (12mg) then you're a turbo fatty and need to let the drug work on your insulin sensitivity over time...or maybe get a diabetes diagnosis? You could have it.

 

[iudex]

Muscle sparing was better on reta (pure lipolysis)

Reta was shown to reduce fatty liver by 84% compared to Tirz achieving approximately 50% in the same timeframe.

That's for obese people that didn't work out. I wonder if the muscle-sparing aspect of working out leads to a similar reduction of Tirz compared to Reta, but I think we'll have to wait for those studies.

 

[Endeavor Fitness]

Is it as simple as that or not ive seen people saying they have taken more and they can “eat what they want” and lose fat and ive seen others say after the supression goes 15mg does no more than 8mg

What is your experience? If your getting zero appetite suppresion when you up it are you just burning your money?

I had a few ppl start on Tirz, then once insulin sensitivity improved, I'd switch them to Reta. Night and day difference on Reta once your sensitivity is clearing, or is cleared up. Compared to just starting on it with sensitivity problems.