More reta = more fat loss?

[Jason_orange12]

Is it as simple as that or not ive seen people saying they have taken more and they can “eat what they want” and lose fat and ive seen others say after the supression goes 15mg does no more than 8mg

What is your experience? If your getting zero appetite suppresion when you up it are you just burning your money?

 

[assielima]

I think I responded to you on another thread. Nevertheless, I don't think you can simply equate increased reta to increased weightloss.

Everyone will react differently, but it will ultimately be a calories in vs calories out type of thing. If Reta is increasing their daily burn that much to allow them to eat all things and still lose, then that person has either good genetics or they are reacting in a advantageous way to the reta (maybe the glucagon agonism). I would also question what people honestly mean by they can "eat what they want"...do these people actually eat that much?

In any case, with grey supply and having a consistent job. I imagine many don't have an issue burning an extra few dollars per pin on some extra mg (Most of my reta supply runs me around .45c/mg or less). The bigger concern to me is whether or not running higher concentrations of a GLP1s is damaging, but personally, I am hoping to taper down on GLP1s once I'm at a healthier goal weight (I am likely the 15mg example that you mentioned ).

 

[iudex]

Calorie intake is still the dominant driver of fat loss. The glucagon-mediated increase in energy expenditure is real, but modest, and it doesn’t replace the need for a caloric deficit. Once you’re at a dose that lets you hit your target calories with minimal effort, pushing higher gives rapidly diminishing returns.

At higher doses, some people do see slightly higher energy expenditure and better nutrient partitioning, but it’s nowhere near enough to offset uncontrolled intake. If appetite suppression levels off around ~8 mg for you, moving to 12-15 mg is unlikely to meaningfully change fat loss unless it actually changes your eating behavior.

Some people get more appetite suppression at higher doses, others don’t. Once appetite is already low, there’s no extra lever to pull. More drug at that point doesn’t mean more fat loss, just higher cost and higher risk of side effects like GI issues, fatigue, sleep disruption, or elevated heart rate.

Thus, the sensible approach is to use the lowest dose that reliably lets you stick to your calorie target, then let consistency and time do the work. Higher dosing only makes sense if it changes intake or sustainability, not because of theoretical metabolic effects.

 

[BigDadd7]

Is it as simple as that or not ive seen people saying they have taken more and they can “eat what they want” and lose fat and ive seen others say after the supression goes 15mg does no more than 8mg

What is your experience? If your getting zero appetite suppresion when you up it are you just burning your money?

No one says they can eat as much as they want. It isn't a fat burner. It's an appetite suppressant with blood sugar control.

 

[Jason_orange12]

No one says they can eat as much as they want. It isn't a fat burner. It's an appetite suppressant with blood sugar control.

They do? Why would i lie

 

[DeodatoFulci]

They do? Why would i lie

Im on a ton of reta sub-reddits, and many other forums and ive never heard anyone say this. And if you have found dopes posting this nonsense then simply ignore it.

 

[Jason_orange12]

Im on a ton of reta sub-reddits, and many other forums and ive never heard anyone say this. And if you have found dopes posting this nonsense then simply ignore it.

Yer agreed mate when people say what they want its probably 2k cals of crap

 

[Trenunaki]

Is it as simple as that or not ive seen people saying they have taken more and they can “eat what they want” and lose fat and ive seen others say after the supression goes 15mg does no more than 8mg

What is your experience? If your getting zero appetite suppresion when you up it are you just burning your money?

No. While the glucagon agonism of Reta does help with raiding calorie burn, this is EXTREMELY MARGINAL. Probably 100-200kcal at most at the highest clinical dose (15mg).

Reta and all glps drive fat loss through their appetite suppresion. Reta is reported to have poor appetite supression mostly by people coming from Sema or from Tirz and not doing a proper dose equivalent. like people going from 5mg tirz to 1mg reta.

Sema seriously does have much more appetite suppresion in its tested doses, this due to it being a much stronger glp1 agonist than the other two, and glp1 is the primary hormone driving fullness, gastric emptying, and such.

If youre already at a moderate Reta dose (anything above 6mg a wk) and the appetite supression "is not enough" youd benefit much more from incorporating some Sema or Cagri(plays off a different receptor, Amylin) then even doubling the Reta dose.

 

[Jason_orange12]

Im on a ton of reta sub-reddits, and many other forums and ive never heard anyone say this. And if you have found dopes posting this nonsense then simply ignore it.

Whats your thoughts on upping dose if its not brining any more suppresion?

If its not bringing supression then wouldnt tirz be the better drug?

 

[Jason_orange12]

No. While the glucagon agonism of Reta does help with raiding calorie burn, this is EXTREMELY MARGINAL. Probably 100-200kcal at most at the highest clinical dose (15mg).

Reta and all glps drive fat loss through their appetite suppresion. Reta is reported to have poor appetite supression mostly by people coming from Sema or from Tirz and not doing a proper dose equivalent. like people going from 5mg tirz to 1mg reta.

Sema seriously does have much more appetite suppresion in its tested doses, this due to it being a much stronger glp1 agonist than the other two, and glp1 is the primary hormone driving fullness, gastric emptying, and such.

If youre already at a moderate Reta dose (anything above 6mg a wk) and the appetite supression "is not enough" youd benefit much more from incorporating some Sema or Cagri(plays off a different receptor, Amylin) then even doubling the Reta dose.

This is how i see it might have to add some cagri even though heard of bad fatiuge and not liking anything at all!

Tirz probably covers all bases as a stand alone if suppresion plus blood sugar managment is the goal

Whats the point in reta if its only 100-200 cal gain a day net but your hungrier

 

[Trenunaki]

Whats your thoughts on upping dose if its not brining any more suppresion?

If its not bringing supression then wouldnt tirz be the better drug?

Tirz and Reta have the same binding affinities to both the Glp1 and GIp receptor. No reason to use tirz over Reta besides cost.

 

[Jason_orange12]

Tirz and Reta have the same binding affinities to both the Glp1 and GIp receptor. No reason to use tirz over Reta besides cost.

Appetite suppresion seems alot stronger on tirz

 

[assielima]

Anecdotally, tirz works a lot more as an appetite suppressor for me. I believe it hits on glp1 and gip harder than reta.

This is why I've considered adding tirz on top of my reta as a way to see if it helps with more suppression. Id prefer to not add sema, even though I did notice more suppression with it, because it historically gives me gi issues.

 

[BigDadd7]

They do? Why would i lie

I don't think you lie, I think they lie

 

[Jason_orange12]

Anecdotally, tirz works a lot more as an appetite suppressor for me. I believe it hits on glp1 and gip harder than reta.

This is why I've considered adding tirz on top of my reta as a way to see if it helps with more suppression. Id prefer to not add sema, even though I did notice more suppression with it, because it historically gives me gi issues.

Am gonna do what you mentioned i think

Im thinking 6mg reta and 6mg tirz rather than keep upping reta and i as you said dont want to use sema

 

[Endeavor Fitness]

They do? Why would i lie

They probably use it in a bulk phase, which you can. But they aren't using crazy high doses for that bulk phase.

 

[Endeavor Fitness]

Whats your thoughts on upping dose if its not brining any more suppresion?

If its not bringing supression then wouldnt tirz be the better drug?

Honestly, if you're looking for appetite suppression as far as the main driver. Tirz is the better option.

 

[ParquetPatquet]

Appetite surpression is not weight loss, otherwise semaglutide or cagrilintide would be breaking all kinds of records.

 

[Jason_orange12]

Appetite surpression is not weight loss, otherwise semaglutide or cagrilintide would be breaking all kinds of records.

If reta’s third glp action only burns about 200 cals a day extra surely tirz and sema what makes u eat less is gonna work better? Reta actually makes me crave carbs after a while it didnt at first but does now

 

[KefirRage]

Reta has a low amount of GLP1. If you are at 4mg/week and still hungry then I recommend adding cagrilintide 0.25mg/week. Cagrilintide lowers food noise more than Semaglutide. Meat, fruit, homemade kefir and no sugar/grains seem to work for me.