Lyle Mcdonald Interview Discussing His New Book, "The GLP-1 Solution"

[aljowa]

People in this forum might find this informative. It's a three-hour interview discussing the highlights and main contents of the book, so quite in-depth; a decent compromise for those who don't want to purchase and read the actual book. Regardless of your personal opinion of Lyle McDonald, I've never come across a substantial critique regarding the intellectual rigor of his content. Anyone interested in the 'GLP-1 revolution' should glean some insight from this interview.


View: https://youtu.be/t7T6Dii-90Q?si=nzv-k4Ed8HnDMV2x

 

[readalot]

but being the colossal cry baby, no citation claims, drama starting cunt

Now, now. That's par for the course with BB/TRT/Drug Gurus. Don't let that distract you.

 

[BigTomJ]

Now, now. That's par for the course with BB/TRT/Drug Gurus. Don't let that distract you.

"guru"


I know he's been around forever and is probably a smart guy, but the years of making claims or starting debates with no citations and crying on Facebook when someone doesn't agree with him on a podcast easily undermine whatever credibility or knowledge he might have.

In my opinion at least

 

[readalot]

"guru"

Haha. Yes, I usually uses the quotes!

He came out and publicly disclosed the bipolar. I hope he is doing well. Genius and mental illness are like PB and J.

But seriously this latest compendium was a let down. Was expecting way more dry details few want to read.

 

[readalot]

Your last sentence here hits my soul, lol. I can relate on a deep level with that one.

Just an anecdote. After a 1 year stint on escitalopram my satiety tolerance has completely changed. I really struggle eating large amounts at all any more. My brain seems to be completely rewired. Currently trying to eat more on a ripped bulk and it is disgusting. Tolerance for packing it in just isn't there anymore.

All the reward signals are damped. Be careful with those SSRIs folks! And careful what you wish for.

 

[aljowa]

So I went through the book last night and fortunately/unfortunately depending on your persuasion it is no where near as detailed as Lyle's previous Ketogenic Diet compendium.

To be quite honest it seems like he just cranked it out as part of the GLP-1 craze. Lots of typical basic diet, fat loss, body fat info but that's also just redux from his prior books and Duchaine's Bodyopus.

That being said I am sure it would potentially help the beginner and I am probably a poor target audience member for his book. The section on lean people using GLP-1 drugs really has next to nothing (appendix).

Thanks again the video @aljowa. I think if someone was to watch that video diligently there is very little else they would get from the book. Definitely not a specialized text on the use of GLP-1 drugs for bodybuilders/lean people, but my expectation going in was probably was too high. Of course it was extremely generous for Lyle to do the video free of charge!

In summary, I don't agree with last sentence in the Introduction... "A complete guide to the GLP-1s containing everything you could ever need to know."

Thanks a lot for providing a brief review of the book, and also potentially saving people time/money by suggesting that the interview is seemingly a sufficient alternative to reading the book. I'm somewhat disappointed that the book isn't up to par with the meticulous standards of most of Lyle's published works. Like you said, probably just riding the wave of the ongoing GLP-1 craze by writing a more beginner-friendly introduction text targeted towards the general population.

 

[aljowa]

Just an anecdote. After a 1 year stint on escitalopram my satiety tolerance has completely changed. I really struggle eating large amounts at all any more. My brain seems to be completely rewired. Currently trying to eat more on a ripped bulk and it is disgusting. Tolerance for packing it in just isn't there anymore.

All the reward signals are damped. Be careful with those SSRIs folks! And careful what you wish for.

I find that quite interesting, since I was under the (perhaps false) impression that SSRIs were typically associated with weight gain in people. I suppose you should consider yourself lucky to end up on that side of the appetite-related side-effect spectrum. I know that I would take appetite suppression over appetite stimulation any day if I had to choose between the two, lol.

 

[readalot]

I find that quite interesting, since I was under the (perhaps false) impression that SSRIs were typically associated with weight gain in people. I suppose you should consider yourself lucky to end up on that side of the appetite-related side-effect spectrum. I know that I would take appetite suppression over appetite stimulation any day if I had to choose between the two, lol.

I would consider it lucky if it didn't come with significant anhedonia. Like really bad. Grateful it stopped the panic/anxiety but in doing so there was some collateral damage. No free lunch.

Have a great evening.

 

[aljowa]

I would consider it lucky if it didn't come with significant anhedonia. Like really bad. Grateful it stopped the panic/anxiety but in doing so there was some collateral damage. No free lunch.

Have a great evening.

Ah, damn. Yeah, I suppose life is an ongoing series of choices that inevitably result in trade-off after trade-off.

"You don't like having chronically elevated anxiety? Hmm, let's see. I have some emotional numbness you can try. Aaand that's pretty much it."

Sorry to hear, though. I do sympathize. Mental/mood disregulation is a bitch. I mostly know it from the depression side of things, but my heart goes out to everyone who struggles with any aspect of mental health.

I'll give a random and crazy anecdote tangentially related. We currently have a patient in the trauma unit I work in with schizophrenia who cut his own dick off with a pair of scissors. Not sure how he got the scissors. Someone at the behavioral health facility he was at fucked up big time. So hey, it could always be worse.

Stay strong and take care of yourself.

 

[AlexDavis43]

If you enjoy Lyle's content, you'll like the video.

If you've been enjoying Lyle's content for a while, you'll know he put this book together in a few weeks (not the first time he's done this).

He's called me a fucktard more than once but I still think he provides good information about training.

 

[BrunoES]

Lyle has an interesting personality lol
In the video he talks about some of the theories about GLP-1's causing other benefits, but as far as I understood his point of view, those are all related to the weight loss.
So, reduced inflammation, glucose related benefits, etc, would be related to weight loss, and not the drug itself.
We have anecdotal evidence on this forum that would say otherwise, but I don't know if we have solid studies looking at it right now.

 

[aljowa]

Lyle has an interesting personality lol
In the video he talks about some of the theories about GLP-1's causing other benefits, but as far as I understood his point of view, those are all related to the weight loss.
So, reduced inflammation, glucose related benefits, etc, would be related to weight loss, and not the drug itself.
We have anecdotal evidence on this forum that would say otherwise, but I don't know if we have solid studies looking at it right now.

The part about the non-weight related benefits of GLP-1s stuck out to me as well. I have also wondered if these benefits are a primary or secondary effect of these medications. I suppose we won't be any closer to the answer until more comprehensive empirical data reveals whether these purported effects occur in subjects who are weight-stable while taking moderate-to-high doses of GLP-1s.

I think a rather large issue that would make these sorts of clinical trials difficult is gathering study participants who are able to take high doses of GLP-1s without experiencing weight-loss. It seems that the majority of folks who are able to take high doses and remain weight-stable are those who have already lost a significant amount of weight while taking these, and are now on a high maintenance dose. The problem is see here is that these people have probably already gotten their blood sugar, fatty liver, sleep apnea, insulin sensitivity, etc, in a healthy state. So even if the GLP-1s have positive effects on these symptoms as a direct, primary effect of the drugs, how much of a further improvement would they practically be able to cause? For example, if someone's fasting blood glucose is down to 68 and their blood pressure is 117/73, how much of a further improvement could be expected by any medication? So essentially, the way I see it is that the only way to formulate a clinical trial that could investigate these questions with any meaningful conclusion would have to somehow recruit a large population of participants who are overweight with unhealthy blood markers and other associated health detriments that they are trying to investigate, and then put all of them on moderate-to-high doses of GLP-1s, but make sure that half of them remain within like 3% of their current body-weight while the other half loses like 15% or more of their bodyweight, and then compare the health data between the two groups. I believe it could be done, but it would be a formidable task. There are also likely many other ways to go about it that more intelligent and knowledgeable minds than I could conjure up.

 

[AlexDavis43]

Lyle has an interesting personality lol
In the video he talks about some of the theories about GLP-1's causing other benefits, but as far as I understood his point of view, those are all related to the weight loss.
So, reduced inflammation, glucose related benefits, etc, would be related to weight loss, and not the drug itself.
We have anecdotal evidence on this forum that would say otherwise, but I don't know if we have solid studies looking at it right now.

To say any benefit is independent of weight loss means it should also happen in the context of a positive energy balance (net fat gain).

A very small energy deficit is enough to account for other health benefits. Effects that would occur prior to significant fat loss.

I don't think we'd see organ health improvement (eg, reduction in fatty liver) with GLP1s if people were gaining weight (body fat), suggesting it's an effect of fat loss.

Not completely ruling it out, but Occam's razor or whatever.

 

[Ghoul]

There is ample evidence of numerous GLP health benefits disassociated from metabolic improvement, and often, the precise mechanism by which it's achieved is elucidated in depth.

Part of the problem is very few dig into that evidence, and what is there is easily dismissed by non-scientists.

It's just much easier to say "It's all related to weight loss, prove me wrong." without lifting a finger.

The simplest example, the mountain of evidence going back decades demonstrating reduced oxidative stress and inflammation via a direct effect of GLP receptor activation in numerous tissues is so well documented, suggesting that doesn't exist outside of weight loss serves as the perfect indicator that zero effort has been put into reading the literature.

 

[brutalbuilt]

if you need a glp-1to lose weight your a pussy tbh

 

[Jin23]

Does lyle have beef with mike israetel? In the beginning of the video, he's showing Mike on video when talking about the current bad trends in the fitnes industry ...

 

[BigTomJ]

Does lyle have beef with mike israetel? In the beginning of the video, he's showing Mike on video when talking about the current bad trends in the fitnes industry ...

he actively talks shit on and beefs with layne norton and mike israetel.

IIRC lyle said some out of pocket shit, layne did a video on it disagreeing with it and lyle went on a flame bender losing his mind over it

 

[AlexDavis43]

Does lyle have beef with mike israetel? In the beginning of the video, he's showing Mike on video when talking about the current bad trends in the fitnes industry ...

he actively talks shit on and beefs with layne norton and mike israetel.

IIRC lyle said some out of pocket shit, layne did a video on it disagreeing with it and lyle went on a flame bender losing his mind over it

If you have another 2 hours to kill, Solomon Nelson interviewed Lyle about his history with Mike. It's pretty savage.

Link

Imo, Solomon invited Greg Doucette on the show to increase view count because Lyle doesn't have a big audience (Greg doesn't really add much).

 

[Jin23]

If you have another 2 hours to kill, Solomon Nelson interviewed Lyle about his history with Mike. It's pretty savage.

Link

Imo, Solomon invited Greg Doucette on the show to increase view count because Lyle doesn't have a big audience (Greg doesn't really add much).

Ah now I remember. I bet Mike is very sorry for ever touching upon these two clowns ...

 

[AlexDavis43]

Ah now I remember. I bet Mike is very sorry for ever touching upon these two clowns ...

When it comes to training knowledge, Lyle is no clown.

 

[Jin23]

When it comes to training knowledge, Lyle is no clown.

Ofc I wasn't referencing to his knowledge, but his attitude. That should have been obvious.