lowest LDL without using a PCSK9 inhibitor?

[Ghoul]

no i calculated it from 92 but still thought it was a great response

It is a strong response even from 92. Perhaps @Raww was on TRT or cruise, or had residual AAS in his system at time of the 92 baseline. The same disproportionate anti-AAS induced lipid rise applies to injectables, but they don’t have anything close to oral’s level of cholesterol trashing capacity on the liver.

Another possible explanation is he’s one of those who absorbs more dietary cholesterol than average, and ezetimibe, which directly counteracts that, has a bigger impact than usual. In some genetic outliers, eze alone can reduce LDL by 80%+.

 

[just some dude]

statin safety profiles

 

[Raww]

It is a strong response even from 92. Perhaps @Raww was on TRT or cruise, or had residual AAS in his system at time of the 92 baseline. The same disproportionate anti-AAS induced lipid rise applies to injectables, but they don’t have anything close to oral’s level of cholesterol trashing capacity on the liver.

Another possible explanation is he’s one of those who absorbs more dietary cholesterol than average, and ezetimibe, which directly counteracts that, has a bigger impact than usual. In some genetic outliers, eze alone can reduce LDL by 80%+.

Yes - TRT for 6+ years.

 

[Ghoul]

Yes - TRT for 6+ years.

Until I learned about the disproportionate impact of Pita on AAS driven lipids, I was starting to think everyone’s tabs might be overdosed, since nearly every report here has been a “stronger than average” LDL reduction.

 

[Ivan221106]

Докато не научих за непропорционалното въздействие на Пита върху липидите, причинени от анаболни стероиди (ААС), започвах да си мисля, че таблетките на всички може да са предозирани, тъй като почти всеки доклад тук е за „по-силно от средното“ намаление на LDL.

How long can the combination of rosuvastatin and ezetimibe be used without interruption?

 

[Ghoul]

How long can the combination of rosuvastatin and ezetimibe be used without interruption?

For most people, forever.

Both have been used for 20+ years without side effects.

Ezetimibe is extremely safe, side effects are almost unheard of.

Rosu does cause side effects in a very small percentage of people. If you don’t get side effects within the first month or two, you will probably never get them. If you do get side effects, stopping the medicine will reverse them.

The only long term effects with Rosu you need to watch are 1) check liver enzymes at least once a year (extremely rare to have a serious problem) and 2) watch out for prediabetes / diabetes. It makes you a little more insulin resistant. It doesn’t really “cause” diabetes, but if you’re close to getting it, this could push you over the edge.

Pitavastatin has a much lower rate of the already low risk of muscle problems, and in most people, it doesn’t increase the chance of diabetes. In fact, it improves insulin sensitivity in many, reducing the risk,

 

[BP_6]

what’s the lowest you’ve managed to get your LDL without using a PCSK9 inhibitor?

20. About 4-5 months ago. Time for another check. With a statin and zetia combo.