Long term tirzepatide efficacy

[CrazyDaisy]

I posted this in another forum, but this forum is probably the better place to ask.

I was on brand name Mounjaro and then compounded tirzepatide via telehealth provider and now getting my own peptide. I'm debating buying a larger stockpile but wondering if others have input if you've been on tirzepatide longer term. Did you find that it stopped working, so maybe buying a large quantity isn't wise? I'm at goal and maintaining BTW. I know people have started getting retatrutide, but I'm not ready to try that until it gets further through clinical trials due to the early heart concerns.

Just curious if anyone has input...don't want to waste a bunch of money on a larger tirzepatide order if many have found its effects to wain or better to consider other stacks. I completely realize this will vary person to person. So just looking for any personal experiences or suggestions.

 

[The_Thinking_Elf]

Observational evidence is of course the weakest kind of evidence, so this isn't a subject I'm prepared to go to the mat on, as I usually would.

I have no idea what the underlying mechanism is that's responsible for that desensitization effect, but it seems the body doesn't like getting supplemental GLPs, coming off, then going back on, whether it's 6 months or 10 years.

I noticed this personally, in others close
to me, then I came across a study where the researchers noticed after completion, anyone who had used one of the very early diabetes GLP meds, even if only for a short period, many years before, did not exhibit as much weight loss on Tirz as the "GLP-Naive".

Then I read an article where a doctor mentioned her practitioner colleagues noticed patients who went off, regained weight. and restarted later needed higher doses to resume weight loss.

The way around that desensitisation of the GLP-1 receptors (which I agree does happen over time) is to develop a compound that upregulates them.

Its a similar issue with say chronic use of Beta-2 adrenoreceptor agonists and using ketotifen to upregulate them after they become desensitised.

I suspect that type of drug development (upregulating GLP-1 receptors) is already in the pipeline because it could also help boost the effectiveness of the various GLP-1 drugs.

 

[DugPrime]

With an injection E5D, I have to higher my dose by 2.5mg every 3-5 weeks or so, and it takes 3-4 months before that I can go back to 2.5mg and have the appetite effect again.