theoldmaster
New Member
As said in the title, is there a less harmful compound that accomplishes this effect?
MESO-Rx
Anabolic Steroids
Is trenbolone the only way to drastically increase IGF-1 sensitivity?
- Thread starter theoldmaster
- Start date
Juicedhead
Member
bro just take exogenous igf-1
theoldmaster
New Member
yes, however sensitizing the receptors would give greater results than both alone and would be very synergistic
Horror Cock
New Member
I assume it's what's written in Sci-Hub | Trenbolone Alters the Responsiveness of Skeletal Muscle Satellite Cells to Fibroblast Growth Factor and Insulin- Like Growth Factor I*. Endocrinology, 124(5), 2110–2117 | 10.1210/endo-124-5-2110
I haven't found any similar articles. Testosterone itself is great at anabolism in multiple ways beyond protein synthesis. I also remember that deleting androgen receptor in the hypothalamus made mice weak and small, even though the muscle AR was still there with plenty of testosterone. I wonder what would happen if the hypothalamus AR was highly agonized while testosterone concentrations are kept stable?
Back to the tren igf1 sensitivity study, these female rats were given, based on my calculations, what for a 100kg human would be 10-20mg of tren per day. Probably lower doses have an effect as well, and I would've said that a micro dose of 1-5mg of tren daily never hurt nobody, but how do we know that tren doesn't sensitize other organs to the same growth factors? Maybe high dose test is safer.
I haven't found any similar articles. Testosterone itself is great at anabolism in multiple ways beyond protein synthesis. I also remember that deleting androgen receptor in the hypothalamus made mice weak and small, even though the muscle AR was still there with plenty of testosterone. I wonder what would happen if the hypothalamus AR was highly agonized while testosterone concentrations are kept stable?
Back to the tren igf1 sensitivity study, these female rats were given, based on my calculations, what for a 100kg human would be 10-20mg of tren per day. Probably lower doses have an effect as well, and I would've said that a micro dose of 1-5mg of tren daily never hurt nobody, but how do we know that tren doesn't sensitize other organs to the same growth factors? Maybe high dose test is safer.
BlueBearFromHell
Suspected alternate account for @Axle Labs
Have you been able to find legit igf-1?
Type-IIx
Member
I am unaware of anything else being demonstrated to have this effect in any model. It's probably common to trienes (Δ4,9,11 androgens) that include, er, well even more harmful compounds like THG ("The Clear") & R1881 (metribolone; methyltrienolone).
Juicedhead
Member
Idk, i have some insubolic two bottles that i will use soon. But i use peptidesciences for all my peptides which I think they are legit.
Type-IIx
Member
Should have replied to your mention, sorry.
Type-IIx
Member
Nah it's also pretty amazing for how effective it is, TBF. That's why it's so tempting. I've also seen guys that seem totally resilient to its harsh effects, but obviously not to the point of getting off "scot free" without having to do annual echos and the like to manage risk.
What dosages would you recommend, I’ve heard 200-400mg being the acceptable dose for tren e.
Type-IIx
Member
I don't recommend any dose. I have found that a dose as low as 100 mg weekly of trenbolone enanthate still causes substantial night sweats & sleep deprivation.
These side effects may not be strongly related to dose, but rather drug related, and are clearly individualized (per-user) effects.
Juicedhead
Member
Use tren a. 50mg eod
Yeah I started getting out of breath on the stuff after 400mg. Knew nothing about it at the time Also never used tren ace because daily pinning is just too much. I find deca easier to manage for a bulk, 400mg of deca, 400 test and that’s all anyone needs really. Insomnia yes, but not nearly as bad as tren.
Juicedhead
Member
yes, If tren is used during a bulk it fucks up digestion for me. Idk what it is but when im on tren if i try to go above like 4-4500 cals i start throwing up after meals. Its fucking weird. I always say tren should never be in a bulk. Just my opinion.
Type-IIx
Member
Androgens and acid reflux, peptic ulcer
Learning about the gut histamine/androgen connection surprised me, so I thought I'd share what I learned about androgens and acid reflux and peptic ulcer, as it is not discussed often. If anyone has any useful information including anecdotes on what's worked for them with respect to AAS-induced...
thinksteroids.com
Further, androgens are toxic. You might be using too high a dose as well.
Type-IIx
Member
I'm ya' mothafuckin' conscience!Type-IIx: "Take Tren Vanargandar"
Okay.
That's nonsense!
Damn, this brought me back.
Similar threads
