white-boyka
New Member
is sema the best for insulin sensitivity out of reta sema and tirz (disregarding its apatite suppression)
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MESO-Rx
Anabolic Steroids
is semaglutide the best insulin sensitizing glp?
- Thread starter white-boyka
- Start date
Ghoul
Member
Tirz is proven best of the three, both in terms of increased insulin sensitivity associated with each pound loss, and independently of weight loss.
Basically, Tirz directly makes fat cells more receptive to storage via GIP (a “sponge” to lower blood glucose) and increasing insulin producing beta cell function,
Basically, Tirz directly makes fat cells more receptive to storage via GIP (a “sponge” to lower blood glucose) and increasing insulin producing beta cell function,
white-boyka
New Member
so tirz is the best one to run when using gh assuming you can eat enough?
Ghoul
Member
Yes. The unknown is whether Reta can produce the same or more sensitivity before appetite suppression becomes too much.
But even small doses of Tirz provide a significant insulin sensitivity boost. It takes a few weeks to fully take effect so you may want to start the Tirz first if you can.
Ghoul
Member
As of now, based on the data Tirz has the edge.
Glucagon makes the liver dump glucose into blood. It’s the way the body prevents hypoglycemia. Reta makes that happen continuously. Good for clearing liver fat, maybe offsets the fatigue some people say they feel on Sema/Tirz, but it’s no surprise raising baseline glucose would blunt the GLP/GIP insulin sensitivity improvements at least a little.
RockyP
Member
The increased insulin sensitivity that comes from GLP-1’s, increased muscle mass / strength training, etc means that your muscle cells will be much more sensitive to any given amount of insulin for a given amount of blood glucose. Basically, it means that when insulin is released, it much more preferentially acts to shove nutrients / amino acids / glucose into muscle cells rather than free fatty acids into adipose. The added (genius) feature of the GLP-1 drugs is that, at least for most people, you will reach some dosage where the appetite suppression is strong enough (but not prohibitively so) to prevent the user from taking in too much shit food to overwhelm their improved insulin sensitivity. Said another way, if someone were to diet and reduce fat without GLP-1’s and then go on an eating binge, their improved insulin sensitivity would be overwhelmed by the massive amount of calories and they’d hold a bunch of water and start filling up adipose tissue. In fact, some bodybuilders have ended up in the ER with pulmonary edema due to post show binge eating (their massively dehydrated state making this much worse of course). The GLP-1 user simply can’t gorge themselves on so much food to do this. I’ve heard anecdotal reports of GLP-1 non responders and I need to meet these people. It’s like they are defying gravity. Idk what one has to do to not lose weight on these meds (assuming you’re not so incredibly unlucky as to be unable to tolerate them).
Ghoul
Member
It does make muscle more insulin sensitive. The focus will be on GIP and fat cells, but to recap if you don’t know, all GLPs make pancreatic beta cells work better, so after eating, insulin is released faster and stronger. This shortens the amount of time needed for insulin to do its job. The less TIME OF EXPOSURE receptors have to insulin, the less insulin resistance develops. This also leads to insulin resistance in receptors gradually reversing. (The receptors literally start to stick out of cells further, like antennas, trying to pick up an insulin signal because they’re not “hearing” insulin constantly any more)
I’ll explain this a couple of ways, because the actual step by step process would be 10x longer. Tirz (and Reta) make fat cells more Insulin sensitive directly with GIP. Better functioning fat cells makes muscle more Insulin sensitive indirectly.
GIP makes fat cells more insulin sensitive so they can do a better job as an energy buffer. When GIP hits adipocytes (fat cells), they respond much more strongly to the insulin that’s released after eating. They quickly soak up excess nutrients out of blood and store them. Later, when insulin drops because we need energy since we’re not eating, GIP opens the door wider to releasing those nutrients back into blood more easily too.
Pay attention to the arrows showing what’s increasing, decreasing, and by how much (2 arrows means it’s a stronger effect) when eating vs fasted.
No Tirz, only natural low levels of GIP pulses activating GIP receptors.
With (TZP) supplementing natural GIP for continuously higher GIP receptor activation:
This improved clearance by fat cells of nutrients from blood lowers the amount of circulating excess lipids muscle is exposed to. It’s the overexposure to high levels of circulating lipids that makes muscle less insulin sensitive.
With Tirz or Reta, muscle isn’t soaking in these excess lipids any more, and as the “grease” clogging muscle’s “insulin ears” clears out muscle becomes more insulin sensitive,
——————-
TLDR:
Old sponge (insulin-resistant fat): leaks grease everywhere -> muscle gets oily, becomes insulin resistant
New sponge (on tirzepatide): soaks up grease -> muscle stays clean, becomes insulin sensitive.
*Stole the illustrations from here:
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