Insomnia from Reta!??

[Proud Pangolin]

Hey guys so i pinned like 2,5 mg of Reta on monday. I think you are suppose to start lower and slowly work your way up with your dosage, but here we are.

Now, i felt somewhat dizzy and had some light diarrhea the last days but thats nothing that would bother me.

However the last nights my sleep was COMPLETE SHIT. Basically i could stay asleep for more than 1h. I woke up this night at least 6 times. Coukdnt find a good sleeping condition, and as i said could stay asleep.

The first day i dient thought much about it but after the last night it really pisses me off.


I cant realky think of anything else that causes this. I also started with some GHRP peptides again (CJC no dac + GHRP-2) but these usually improve my sleep. Never had a bad reaction on them.

Any advise? Is this a common sideeffect? Was my first dosage to high?

 

[keengkong]

I didn't think reta was causing the insomnia I was experiencing. However, it went away shortly after I stopped taking retatrutide.

I had very slowly went up on reta. In my case, progressing slowly didn't keep insomnia from happening.

 

[nixu]

Well i also take GHRHs + GHRP before bed. Didnt really help with the sleep.
2,5IU of GH however did wonders and i slept like a toddler.
But i dont know if "starting to take GH soley so i can tolerate Reta" is the right approach

Obviously adding another compound just to tolerate side effects of the first one sounds hilarious, but on other hand... (correct me if I am wrong)

Combining Reta with small dose of GH, will achieve better results in lost Fat / Muscle ratio?

 

[eryximachus]

Obviously adding another compound just to tolerate side effects of the first one sounds hilarious, but on other hand... (correct me if I am wrong)

Combining Reta with small dose of GH, will achieve better results in lost Fat / Muscle ratio?

We just don't know. The drug is not FDA approved yet so the research isn't public record in its entirety.

The whole GLP-1/HGH thing was because HGH can (and most likely will over a long enough timeline) cause diabetes. But this never made sense to me as metformin alone always seemed to work well for this purpose.

But in my personal recent experience, I lost way too much weight on reta. Like 40 pounds in 3 months. I just started eating a lot and while I can't sleep right now after midnight, I have more energy.

It was so bad I got prescription Vyvanse 2 weeks ago (20mg, below therapeutic dose). Barely helped me stay awake. Reta increase pulse by about the same as amphetamine, so that sucked (95 for me).

Reta is a strong drug. But I need to get blood lipids under control and it seems to do this. I will probably go down to 2mg per week. I was able to handle that OK I think. I'm on the fence though and I'm going to skip this week and see how I feel.

 

[Proud Pangolin]

Obviously adding another compound just to tolerate side effects of the first one sounds hilarious, but on other hand... (correct me if I am wrong)

Combining Reta with small dose of GH, will achieve better results in lost Fat / Muscle ratio?

Yes but im on 2mg Tesamorelin+ 500mcg Ipamorelin before bed as well as 2x 100mcg CJC no Dac +100mcg GHRP-2 (right after waking up and after the gym) right now so i would have to switch completely to GH.

Interestingly, while the peptides in general increased my sleep quality A LOT, it seems that they fail regarding Insomnia from Reta.

GH generally increases insulin resistance while Reta decreses it, and the reason why i got Insomnia from Reat was simply because i got Hypoglycemia at night. So probably thats why GH worked better than peltides?

 

[Proud Pangolin]

We just don't know. The drug is not FDA approved yet so the research isn't public record in its entirety.

The whole GLP-1/HGH thing was because HGH can (and most likely will over a long enough timeline) cause diabetes. But this never made sense to me as metformin alone always seemed to work well for this purpose.

But in my personal recent experience, I lost way too much weight on reta. Like 40 pounds in 3 months. I just started eating a lot and while I can't sleep right now after midnight, I have more energy.

It was so bad I got prescription Vyvanse 2 weeks ago (20mg, below therapeutic dose). Barely helped me stay awake. Reta increase pulse by about the same as amphetamine, so that sucked (95 for me).

Reta is a strong drug. But I need to get blood lipids under control and it seems to do this. I will probably go down to 2mg per week. I was able to handle that OK I think. I'm on the fence though and I'm going to skip this week and see how I feel.

What i really dont understand is: why would you keep taking something that fucks up your sleep so badly ?!!!

 

[nixu]

We just don't know. The drug is not FDA approved yet so the research isn't public record in its entirety.

The whole GLP-1/HGH thing was because HGH can (and most likely will over a long enough timeline) cause diabetes. But this never made sense to me as metformin alone always seemed to work well for this purpose.

But in my personal recent experience, I lost way too much weight on reta. Like 40 pounds in 3 months. I just started eating a lot and while I can't sleep right now after midnight, I have more energy.

It was so bad I got prescription Vyvanse 2 weeks ago (20mg, below therapeutic dose). Barely helped me stay awake. Reta increase pulse by about the same as amphetamine, so that sucked (95 for me).

Reta is a strong drug. But I need to get blood lipids under control and it seems to do this. I will probably go down to 2mg per week. I was able to handle that OK I think. I'm on the fence though and I'm going to skip this week and see how I feel.

Interesting.

I've started this week Reta and gonna try to follow research dosing. I am gonna split single dose into 2 doses for the beginning. Currently taking 1mg every 3 day to achieve 2mg weekly dosing, gonna do this for 4 weeks and see if it will be possible to slowly up the dose and move into single weekly injection.

My goal is to tolerate 4-6mg to have the best outcome from Reta. Currently everything is going smoothly with minimal side effects, but its only a beginning for me.

I am aware that it varies a lot person to person how they tolerate GLP-1 dosing and side effects can be very different for each, but as far I am aware, side effects should slowly get better.

What was your dosing protocol, do you think you upped the dose too fast?

 

[lamehack]

reta can 100% cause sleep issues. i go to bed at 9pm and sleep till 3am like a rock, then its broken shit. GH makes it worse due to stimulation. weed helps, but gives me next day hangover and i dont like it

 

[nixu]

reta can 100% cause sleep issues. i go to bed at 9pm and sleep till 3am like a rock, then its broken shit. GH makes it worse due to stimulation. weed helps, but gives me next day hangover and i dont like it

I noticed same last week. I think I still get good quality sleep. I wake up a couple of hours earlier than I normally would. Don't feel tired (yet) though, so I don't mind, so far see it as a bonus. The early bird gets the worm, or some shit like that.

I though late night GH injection would help with better sleep?

 

[Bandern]

Started reta about 3 weeks ago and was getting shit sleep waking up every 2 hours. A small amount of carbs right before bed seems to have fixed the issue

 

[lamehack]

I noticed same last week. I think I still get good quality sleep. I wake up a couple of hours earlier than I normally would. Don't feel tired (yet) though, so I don't mind, so far see it as a bonus. The early bird gets the worm, or some shit like that.

I though late night GH injection would help with better sleep?

yeah well i thought as well, but at doses at which it makes sense IMHO, like 4IU, they work stimulating for me. i settled at 2IU AM for now, and in theory this should not disrupt night-time production

 

[BuffMaltese]

I was dead set on making Reta work, even though it instantly wrecks my sleep. I tried every sleep med, supplement, and random tip I could find with no luck. After finally getting my sleep back to normal, I tried Reta again for the fourth time because I never learn, and came across the suggestion to take tart cherry and berberine. To my surprise, they actually worked. I’m not sure how, but now I can function while on Reta. As I’ve increased the dose, I’m still waking up throughout the night, but it’s nowhere near as bad and I feel fine during the day.

 

[keengkong]

I was dead set on making Reta work, even though it instantly wrecks my sleep. I tried every sleep med, supplement, and random tip I could find with no luck. After finally getting my sleep back to normal, I tried Reta again for the fourth time because I never learn, and came across the suggestion to take tart cherry and berberine. To my surprise, they actually worked. I’m not sure how, but now I can function while on Reta. As I’ve increased the dose, I’m still waking up throughout the night, but it’s nowhere near as bad and I feel fine during the day.

Small studies have shown a benefit of using tart cherry juice to improve sleep. Tart Cherry Juice for Sleep: Current Research Into Why It Might Work I'm glad berberine and tart cherry juice work for you.

 

[Turkeybuilder]

ive been on reta for like 14 weeks now i noticed zero difference in my sleep. weird

 

[ChokeHldCharlie]

I'm going on 7 weeks at 2mg and sleep like a baby now.

 

[keengkong]

ive been on reta for like 14 weeks now i noticed zero difference in my sleep. weird

I don't think it's that weird. People on medications often experience different side effects.

 

[SlamSumTest]

Yeah I consistently wake up at 3am to pee quite a bit and can’t sleep. Going to bed is easy but I have been waking up in the middle of the night with quite a bit of energy.

I suspect it is the steep caloric deficit causing a cortisol spike at night. Either that or the glucagon agonist part consistently keeps your glucose and glycogen low, which would also lead to cortisol spiking at night and waking you up.

Overall, the results on Reta have been great but the insomnia + RHR increase isn’t worth it especially when you can get stronger appetite suppression from Sema/Tirz. Looking forward to finishing the rest of my Reta and diving into my Tirz stash to maintain my new set bodyfat/weight

 

[jdel_gar]

I'm only on 3 weeks but I started at 1mg. I'm also on TRT but I haven't had any issues sleeping. Hopefully I don't when I go up to 2mg on my next dose.

Same with me! at 1.5mg of reta now and down 8lbs in 3 weeks. I also added cjc/ipa and have slept better than I have in years however the flushing I get after pinning the cjc/ipa isnt great. Im gonna switch to tesa when im done with this vial.

 

[krvuxn]

0.5mg has fucked my sleep, tempted to try 0.25mg but seems like it’s not high enough of a dose to make it worth the syringe I’d use to inject it with. I might just stop using it until I’m in prep, because then I don’t sleep anyway.

 

[masternak]

Yeah, the sleep thing seems hit or miss. Some people adjust after a few days like Luweez, others don't. Maybe try to stick it out a bit longer since you're already seeing some effects?

 

[SlamSumTest]

Anyone experiencing this on Tirz? I plan to just take the smallest dose of possible after hitting my BF goes and ditching Reta. I sleep from 9:30am and wake up at 3am ish, then stay awake until 5 then get another hour.

Not ideal, also notice I’m peeing a lot. The weight loss is substantial so far so I’m leaning towards this being a function of being in a steep caloric deficit