HGH + Retatrutide

[Y2_dyc]

I’m currently on a TRT dose of 150mg per week, and 1.5mg of reta per week.

I’ve got HGH and looking to start at a conservative dose of 2iu daily and titrate slowly to 4iu.

What time of the day AM vs PM would be most ideal? And with the positive effect of insulin sensitivity from using the reta, is there more of an argument that timing of the day is less important (provided that I take HGH fasted or 2-3 hours after my last meal)?

 

[Ghoul]

I’m currently on a TRT dose of 150mg per week, and 1.5mg of reta per week.

I’ve got HGH and looking to start at a conservative dose of 2iu daily and titrate slowly to 4iu.

What time of the day AM vs PM would be most ideal? And with the positive effect of insulin sensitivity from using the reta, is there more of an argument that timing of the day is less important (provided that I take HGH fasted or 2-3 hours after my last meal)?

What's your priority? Fat loss / anti-aging aesthetics, or anabolic effects?

 

[Y2_dyc]

I’d say priority is fat loss/anti aging aesthetics.

Would that be an important factor when deciding timing protocols for administering HGH?

 

[Ghoul]

I’d say priority is fat loss/anti aging aesthetics.

Would that be an important factor when deciding timing protocols for administering HGH?

Delaying GH conversion to IGF as much as possible. IGF conversion is accelerated by insulin release, ie, eating (esp carbs). A fasted state will maintain max circulating GH as long as possible, which is roughly 3-4 hours post injection.

GH is responsible for enhanced fat lipolysis (signals fat cells to release free fatty acids and conditions muscles to use them for energy). Visible anti-aging effects, particularly skin quality, are a function of GH, not IGF.

If you have weight to lose, and/or you're susceptible to diabetes (get an A1C blood test before starting, as well as baseline IGF, both cheap tests), Tirz will work better than Reta. Its insulin sensitivity improving (ie, anti-diabetic) effects are superior to Reta. Reta will dump even more glucose into your blood, potentially worsening the situation if you're borderline pre-diabetic.

 

[newguy2]

Tirz will work better than Reta. Its insulin sensitivity improving (ie, anti-diabetic) effects are superior to Reta. Reta will dump even more glucose into your blood, potentially worsening the situation if you're borderline pre-diabetic.

Wow interesting, sometimes I wonder why I switched from tirz to reta. fomo?

 

[Y2_dyc]

Ah how interesting. I’m following Jordan Peters ridiculous log on his forum where he’s pumping multiple peptides/gear daily. His insulin sensitivity was good enough despite taking 24iu of GH. He was using 0.5mg of reta daily.

Thanks for the info Ghoul.

Am I right to think that if I administer 2 hours after my last meal/pre bed, the GH won’t begin to peak till 1-2 hours into my sleep. What’s your preference of pre bed HGH shots vs injecting first thing after you wake up.

 

[lilhawk]

Just take the GH when it's convenient for you. It doesn't make a bit of difference when you take it. I have tried it every way imaginable and the results are the exact same. So I just take it all before bed. I take Reta at 1.5mg per week and it keeps my blood glucose in the 80's no matter how much GH I take up to 10iu per day. Reta and GH is the combo to take. It is literally impossible to get fat with that combo.

 

[Avarice911]

I’ve found that taking the whole dose prebed or split between am/pm or bed/preworkout made no difference.

Reference- 2 years of GH use, 2-6iu and varied injection times lol

 

[Lifting88]

Delaying GH conversion to IGF as much as possible. IGF conversion is accelerated by insulin release, ie, eating (esp carbs). A fasted state will maintain max circulating GH as long as possible, which is roughly 3-4 hours post injection.

GH is responsible for enhanced fat lipolysis (signals fat cells to release free fatty acids and conditions muscles to use them for energy). Visible anti-aging effects, particularly skin quality, are a function of GH, not IGF.

If you have weight to lose, and/or you're susceptible to diabetes (get an A1C blood test before starting, as well as baseline IGF, both cheap tests), Tirz will work better than Reta. Its insulin sensitivity improving (ie, anti-diabetic) effects are superior to Reta. Reta will dump even more glucose into your blood, potentially worsening the situation if you're borderline pre-diabetic.

What the min dosed needed for tirza to benefit from the anti imflamation and insulin sensitivity

 

[BigManBlastoise]

Anyone seen data on if pumping up the retatrutide dose closer to the max dose lets you take even more GH without taking a hit to fasting glucose and insulin resistance?

I plan to start really conservative and monitor blood glucose consistently to see if it's worth pushing the dose but I'm curious what others have seen. Already on 10mg/wk of retatrutide, potentially 60lbs left to lose so I'll be hitting 12mg in 3 weeks so I can red line the reta the rest of the way down I figure this might be the best time to see what I can get away with on the GH side of things.

I told myself I get to take the GH if I do at least 30 minutes of zone 2 cardio for the next 30 days and adhere strictly to my diet. Diet part should be easy but cardio is a new habit for me.

 

[Ghoul]

Anyone seen data on if pumping up the retatrutide dose closer to the max dose lets you take even more GH without taking a hit to fasting glucose and insulin resistance?

I plan to start really conservative and monitor blood glucose consistently to see if it's worth pushing the dose but I'm curious what others have seen. Already on 10mg/wk of retatrutide, potentially 60lbs left to lose so I'll be hitting 12mg in 3 weeks so I can red line the reta the rest of the way down I figure this might be the best time to see what I can get away with on the GH side of things.

I told myself I get to take the GH if I do at least 30 minutes of zone 2 cardio for the next 30 days and adhere strictly to my diet. Diet part should be easy but cardio is a new habit for me.

The closer to the max dose the tighter the glucose control will be and the higher GH you can tolerate without building insulin resistance.

 

[Ateam2023]

I had to stop using Reta, even at .75 mg week it made me not want to eat, it sucks because I did like the bg benefits I was getting,

 

[johnjay06]

I had to stop using Reta, even at .75 mg week it made me not want to eat, it sucks because I did like the bg benefits I was getting,

Odd. That low of a dose shouldn’t have done anything for you. The trials started at 2mg and titrated up from there. I’m up to 8mg and still get hunger especially when I’m closer to my injection window.

 

[BigManBlastoise]

I didn't get any appetite suppression until I was at 4mg. I would not doubt that I have 12 times the appetite of some folks too though. You don't get morbidly obese eating like a bird. I could still overeat if I wanted.

I am going to experiment with the gh dose a bit and see what happens. Not on aas though so there's a point of diminishing return as I understand it so experiment within reason.

 

[Ateam2023]

Odd. That low of a dose shouldn’t have done anything for you. The trials started at 2mg and titrated up from there. I’m up to 8mg and still get hunger especially when I’m closer to my injection window.

I realize what the "science says" but i just couldn't eat, i lost like 3.5 lbs in two weeks and just didn't even want food. I really liked the bg benefits , but couldn't hang

 

[Bandern]

I realize what the "science says" but i just couldn't eat, i lost like 3.5 lbs in two weeks and just didn't even want food. I really liked the bg benefits , but couldn't hang

It’s funny how differently it hits everyone. I see people reporting little to no appetite suppression upwards of 10mg. Meanwhile I’m on 2mg and eating my already low cutting cals feels like a chore

 

[Ateam2023]

It’s funny how differently it hits everyone. I see people reporting little to no appetite suppression upwards of 10mg. Meanwhile I’m on 2mg and eating my already low cutting cals feels like a chore

I would eat like half my meal and be like , f this , this is gross.

 

[adrenalytic]

I realize what the "science says" but i just couldn't eat, i lost like 3.5 lbs in two weeks and just didn't even want food. I really liked the bg benefits , but couldn't hang

My first run with reta was like that too, bro. I never got above 2 mg because I was living on fumes (1700 kcal/wk) but it was ok, I lost 45 lbs. in 3 months. Totally worth it.

Now, my second run with it, I barely get any hunger suppression at 4 mg. Which is good because now I have my shit dialed in and will never be obese again.

 

[eryximachus]

My first run with reta was like that too, bro. I never got above 2 mg because I was living on fumes (1700 kcal/wk) but it was ok, I lost 45 lbs. in 3 months. Totally worth it.

Now, my second run with it, I barely get any hunger suppression at 4 mg. Which is good because now I have my shit dialed in and will never be obese again.

Exactly my story. Lost 45 pounds in 3 months. 230 to 185. Problem is now I see how much muscle I've lost. a new battle. Also proof that lower dose androgens won't save you if you're in a summer cardio mode. I took 400mg of primo that whole time along with high rep low eight lifting as I just could not stand being fat anymore.

HGH made my face look great though, and overall I look great. But it's a bitch starting over.

 

[adrenalytic]

But it's a bitch starting over.

I lost some strength and size too but you're never really starting over. Muscle memory is a fantastic thing. I got it all back and then some in about 3 months.