HGH Dosing Protocol

[BR1217]

I have heard many different things concerning dosing with HGH. Need some help from some experienced HGH guys here. Once per day , morning or evening? Twice per day, once before bed and once upon rising. My main goal is to lose some BF. I am currently sitting at 13%, would like to get down to 10% or less. I am 39 years old, 5'10", 237, and on TRT at 400mg/week from my TRT doc. Wanting to run the HGH for at least 6 months, preferably forever.

So the question is once per day or twice per day and when?

 

[johnnyBALLZ]

I have heard many different things concerning dosing with HGH. Need some help from some experienced HGH guys here. Once per day , morning or evening? Twice per day, once before bed and once upon rising. My main goal is to lose some BF. I am currently sitting at 13%, would like to get down to 10% or less. I am 39 years old, 5'10", 237, and on TRT at 400mg/week from my TRT doc. Wanting to run the HGH for at least 6 months, preferably forever.

I dose 5iu per day.. 2.5iu right when I wake up injected subcutaneously into problem areas(stomach). It's important to wait at least 30min to eat after injection although I've read it's fine to have whey..

The second injection of 2.5iu is early afternoon immediately post workout injected intramuscularly into whatever muscles were worked that day.

 

[BR1217]

I dose 5iu per day.. 2.5iu right when I wake up injected subcutaneously into problem areas(stomach). It's important to wait at least 30min to eat after injection although I've read it's fine to have whey..

The second injection of 2.5iu is early afternoon immediately post workout injected intramuscularly into whatever muscles were worked that day.

What is the deal with waiting to eat?

 

[WhiteLedgen]

I dose 5iu per day.. 2.5iu right when I wake up injected subcutaneously into problem areas(stomach). It's important to wait at least 30min to eat after injection although I've read it's fine to have whey..

The second injection of 2.5iu is early afternoon immediately post workout injected intramuscularly into whatever muscles were worked that day.

Why im if i can ask ? I never hear that before,,...

 

[beezil]

What is the deal with waiting to eat?

you don't want to eat sugar... the insulin will cause issues with the GH.

I wait approx. 45 min prior to eating.. atleast anything with high glycemic carbs.

I inject 2iu. upon rising in the am. (5on - 2off...inject protocol)\

 

[BR1217]

you don't want to eat sugar... the insulin will cause issues with the GH.

I wait approx. 45 min prior to eating.. atleast anything with high glycemic carbs.

I inject 2iu. upon rising in the am. (5on - 2off...inject protocol)\

So I could inject upon rising and still eat my eggs, just no oatmeal or juice for 45 minutes.

As part of my workout program I am going to start doing 1 hour of cardio upon rising (fasted). Should I take the GH before cardio or after?

 

[mands]

I was having a conversation on another forum with someone and we were hashing it out on what would be the best way to run GH for bb'er.

This is what it looks like:

Morning AM - SubQ injection
Afternoon post workout - IV injection(do not advise with generics)
3 hour after IV injection/Bedtime - SubQ

Even though SubQ and IM injections yield almost identical peak and duration levels, SubQ is still a little higher.

IV has a much higher peak serum level and has a much shorter duration.

mands

 

[BR1217]

I was having a conversation on another forum with someone and we were hashing it out on what would be the best way to run GH for bb'er.

This is what it looks like:

Morning AM - SubQ injection
Afternoon post workout - IV injection(do not advise with generics)
3 hour after IV injection/Bedtime - SubQ

Even though SubQ and IM injections yield almost identical peak and duration levels, SubQ is still a little higher.

IV has a much higher peak serum level and has a much shorter duration.

mands

Do you know of any studies confirming the IV peak and duration? How long would I need to wait after an IV shot to get serum levels tested? I am assuming it would be much shorter than the recommended 3 hours for sub-q shots.

 

[mands]

Do you know of any studies confirming the IV peak and duration? How long would I need to wait after an IV shot to get serum levels tested? I am assuming it would be much shorter than the recommended 3 hours for sub-q shots.

If I remember right the 2-3 hour mark on SubQ, IM and IV are all about the same. IV just drops off tremendously quicker. It also starts a lot higher.

I will search for the study and graph. Dr. Scally posted it up initially I believe.

mands

 

[beezil]

So I could inject upon rising and still eat my eggs, just no oatmeal or juice for 45 minutes.

As part of my workout program I am going to start doing 1 hour of cardio upon rising (fasted). Should I take the GH before cardio or after?

BR,

i do my cardio first... then take my GH... and then start cooking my eggs.

i eat my oatmeal with protein... approx 45 min later...

i hope this helps.

 

[BR1217]

BR,

i do my cardio first... then take my GH... and then start cooking my eggs.

i eat my oatmeal with protein... approx 45 min later...

i hope this helps.

Looks like we have a similar morning schedule. Thanks

 

[BR1217]

Any of you guys experience severe leg cramps at night from GH? I have been running 4iu/day and have had some wicked cramps at night.

 

[dnoyez]

What is the deal with waiting to eat?

study was performed using ghrh

Elevated insulin levels contribute to the reduced growth hormone (GH) response to GH-releasing hormone in obese subjects.

Lanzi R, Luzi L, Caumo A, Andreotti AC, Manzoni MF, Malighetti ME, Sereni LP, Pontiroli AE.


Author information
Istituto Scientifico San Raffaele, Divisione di Medicina Interna, Unità di Bioingegneria, Università degli studi di Milano, Milan, Italy.


Abstract


We have recently presented experimental evidence indicating that insulin has a physiologic inhibitory effect on growth hormone (GH) release in healthy humans. The aim of the present study was to determine whether in obesity, which is characterized by hyperinsulinemia and blunted GH release, insulin contributes to the GH defect. To this aim, we used a simplified experimental protocol previously used in healthy humans to isolate the effect of insulin by removing the interference of free fatty acids (FFAs), which are known to block GH release. Six obese subjects (four men and two women; age, 30.8 +/- 5.2 years; body mass index, 36.8 +/- 2.8 kg/m2 [mean +/- SE]) and six normal subjects (four men and two women; age, 25.8 +/- 1.9 years; body mass index, 22.7 +/- 1.1 kg/m2) received intravenous (i.v.) GH-releasing hormone (GHRH) 0.6 microg/kg under three experimental conditions: (1) i.v. 0.9% NaCl infusion and oral placebo, (2) i.v. 0.9% NaCl infusion and oral acipimox, an antilipolytic agent able to reduce FFA levels (250 mg at 6 and 2 hours before GHRH), and (3) euglycemic-hyperinsulinemic clamp (insulin infusion rate, 0.4 mU x kg(-1) x min(-1)). As expected, after placebo, the GH response to GHRH was lower for obese subjects versus normals (488 +/- 139 v 1,755 +/- 412 microg/L x 120 min, P < .05). Acipimox markedly reduced FFA levels and produced a mild reduction of insulin levels; under these conditions, the GH response to GHRH was increased in both groups, remaining lower in obese versus normal subjects (1,842 +/- 360 v 4,871 +/- 1,286 microg/L x 120 min, P < .05). In both groups, insulin infusion yielded insulin levels usually observed under postprandial conditions and reduced circulating FFA to the levels observed after acipimox administration. Again, the GH response to GHRH was lower for obese subjects versus normals (380 +/- 40 v 1,075 +/- 206 microg/L x 120 min, P < .05), and in both groups, it was significantly lower than the corresponding response after acipimox. In obese subjects, as previously reported in normals, the GH response to GHRH was inversely correlated with the mean serum insulin (r = -.70, P < .01). In conclusion, our data indicate that in the obese, as in normal subjects, the GH response to GHRH is a function of insulin levels. The finding that after both the acipimox treatment and the insulin clamp the obese still show higher insulin levels and a lower GH response to GHRH than normal subjects suggests that hyperinsulinemia is a major determinant of the reduced GH release associated with obesity.

 

[Bucky]

I dose 5iu per day.. 2.5iu right when I wake up injected subcutaneously into problem areas(stomach). It's important to wait at least 30min to eat after injection although I've read it's fine to have whey..

The second injection of 2.5iu is early afternoon immediately post workout injected intramuscularly into whatever muscles were worked that day.

Holy fuck if that's generic. Did you work up to that amount? The rips at 3iu/day set my hands on fire.

 

[BR1217]

study was performed using ghrh

Elevated insulin levels contribute to the reduced growth hormone (GH) response to GH-releasing hormone in obese subjects.

Lanzi R, Luzi L, Caumo A, Andreotti AC, Manzoni MF, Malighetti ME, Sereni LP, Pontiroli AE.


Author information
Istituto Scientifico San Raffaele, Divisione di Medicina Interna, Unità di Bioingegneria, Università degli studi di Milano, Milan, Italy.


Abstract


We have recently presented experimental evidence indicating that insulin has a physiologic inhibitory effect on growth hormone (GH) release in healthy humans. The aim of the present study was to determine whether in obesity, which is characterized by hyperinsulinemia and blunted GH release, insulin contributes to the GH defect. To this aim, we used a simplified experimental protocol previously used in healthy humans to isolate the effect of insulin by removing the interference of free fatty acids (FFAs), which are known to block GH release. Six obese subjects (four men and two women; age, 30.8 +/- 5.2 years; body mass index, 36.8 +/- 2.8 kg/m2 [mean +/- SE]) and six normal subjects (four men and two women; age, 25.8 +/- 1.9 years; body mass index, 22.7 +/- 1.1 kg/m2) received intravenous (i.v.) GH-releasing hormone (GHRH) 0.6 microg/kg under three experimental conditions: (1) i.v. 0.9% NaCl infusion and oral placebo, (2) i.v. 0.9% NaCl infusion and oral acipimox, an antilipolytic agent able to reduce FFA levels (250 mg at 6 and 2 hours before GHRH), and (3) euglycemic-hyperinsulinemic clamp (insulin infusion rate, 0.4 mU x kg(-1) x min(-1)). As expected, after placebo, the GH response to GHRH was lower for obese subjects versus normals (488 +/- 139 v 1,755 +/- 412 microg/L x 120 min, P < .05). Acipimox markedly reduced FFA levels and produced a mild reduction of insulin levels; under these conditions, the GH response to GHRH was increased in both groups, remaining lower in obese versus normal subjects (1,842 +/- 360 v 4,871 +/- 1,286 microg/L x 120 min, P < .05). In both groups, insulin infusion yielded insulin levels usually observed under postprandial conditions and reduced circulating FFA to the levels observed after acipimox administration. Again, the GH response to GHRH was lower for obese subjects versus normals (380 +/- 40 v 1,075 +/- 206 microg/L x 120 min, P < .05), and in both groups, it was significantly lower than the corresponding response after acipimox. In obese subjects, as previously reported in normals, the GH response to GHRH was inversely correlated with the mean serum insulin (r = -.70, P < .01). In conclusion, our data indicate that in the obese, as in normal subjects, the GH response to GHRH is a function of insulin levels. The finding that after both the acipimox treatment and the insulin clamp the obese still show higher insulin levels and a lower GH response to GHRH than normal subjects suggests that hyperinsulinemia is a major determinant of the reduced GH release associated with obesity.

Please help me here. This study was using GHRH which stimulates your body's natural production of GH. Insulin is shown to blunt the release. What about when you use real GH, then you are adding a substantial amount of GH into the system. What effect does insulin have on already present GH?

 

[dnoyez]

Please help me here. This study was using GHRH which stimulates your body's natural production of GH. Insulin is shown to blunt the release. What about when you use real GH, then you are adding a substantial amount of GH into the system. What effect does insulin have on already present GH?

Insulin raised from blood sugar levels can compete with administered hgh for the same receptor sites also if you shoot gh you're insulin is less effective and bg will rise (hyper). Also because of that you keep making more and more insulin. Could lead to diabetes in the long run.

Therefore many believe not to eat +- one hour before and 2 hours after a shot.

 

[BR1217]

Insulin raised from blood sugar levels can compete with administered hgh for the same receptor sites also if you shoot gh you're insulin is less effective and bg will rise (hyper). Also because of that you keep making more and more insulin. Could lead to diabetes in the long run.

Therefore many believe not to eat +- one hour before and 2 hours after a shot.

Thanks dnoyez!

 

[TakItEz]

Good thread

 

[Mr MASSE]

Isn't in the USA a book out like in... where all synergies between GH AAS T3 and or T4 AND INSULIN IS EXPLAINED? I have a book where also the biological correlations are shown!? And all know AAS are described and also some protocol for using it all...
I see here always the fucking same questions..

Maybe someone of you know a good book where it all is well and deep explanation is written..?
Please post the name of the book for all questions for all our beginners...

Or anybody who has time to write a complete post about all and then we can do a sticky here..

 

[RingMeister01]

I administer gh as soon as I wake up AND immediately eat 1 1/2 cup oatmeal (with 2 scoops low carb whey) before I head out to the gym at 4.30am. I eat 5 boiled eggs when I get home around 6.30am

Should I be administering the GH post workout in my case to avoid the carbs in the oatmeal?? Or am I ok?

Oatmeal has is low GI but I don't want the risk of type 2 diabetes.

Maybe I'm buggin

Thanks guys



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