HGH Anything you wish you knew before you got started?

[Ghoul]

My most recent labs showed:
- Free Testosterone (Direct) fell from 10.1 in September (right before starting HGH) to 6.3 (reference range 6.8-21.5) a few weeks ago.
- TSH/Free T4/Free T3 are all in-range.
- Insulin jumped from 11 to 19.8, which is in reference range but a significant jump.

I started on metformin about 3 weeks ago to help avoid insulin resistance (I'm hovering just below pre-diabetic A1C threshold, 5.6, and have family history of diabetes).

Any thoughts on what might be going on here? Taking 2.5iu daily in the morning, 3 hours before any food. Metformin 500mg after breakfast and again after dinner. IGF-1 is 325, up from a pre-GH baseline of 132.

Initiating Metformin use is associated with a drop in testosterone. There are a number of studies showing this.

https://diabetesjournals.org/care/article/44/4/1059/138596/Rapid-Changes-in-Serum-Testosterone-in-Men-With

The Effect of Metformin on Male Reproductive Function and Prostate: An Updated Review

Tseng CH. World J Mens Health. 2022 Jan;40(1):11-29. https://doi.org/10.5534/wjmh.210001

wjmh.org