An excess of a ligand, hcg in this case, for long enough will result in the ligands receptor down-regulation, fewer receptors to bind with the hcg, and a reduced response. Its the same thing that happens with chronic opiate use. Its also called tolerance to the drug. Reduce or stop the hcg and the receptors will up regulate in time. The 64$ question is how much and how long. No studies of hcg and receptor responce have been done.
MESO-Rx
Anabolic Steroids
HCG can PERMANANTLY desensitize the ledyig cells?
- Thread starter Hcg69
- Start date
An excess of a ligand, hcg in this case, for long enough will result in the ligands receptor down-regulation, fewer receptors to bind with the hcg, and a reduced response. Its the same thing that happens with chronic opiate use. Its also called tolerance to the drug. Reduce or stop the hcg and the receptors will up regulate in time. The 64$ question is how much and how long. No studies of hcg and receptor responce have been done.
You do not indicate the reference point?
REgarding the HCG. Keep in mind it is sealed in amps as a protectant from Oxagen degredation. Not temps so to speak. So I was sorta referencing a little bit of a different notion. The refrigeration after opening is to slow the reaction with the O2 (I am pretty sure). So keep in mind its not a great thing to mix with more water than intended as this expedites the O2 based degredation. I dont think its a great idea to "mix it agressively either" if preparing for extended use. I think you also made reference to a "sodium". Perhaps I am hallucinating. But if - not so. It is mixed with a 0.9 solution of BAC water which is simply steril water with Benzyl alcohol added to almost 1%. This helps to keep clean and prevent pain.... It WILL feel like you were hit in the gut with a golf ball if you go steril water only, I have heard....
REgarding the HCG. Keep in mind it is sealed in amps as a protectant from Oxagen degredation. Not temps so to speak. So I was sorta referencing a little bit of a different notion. The refrigeration after opening is to slow the reaction with the O2 (I am pretty sure). So keep in mind its not a great thing to mix with more water than intended as this expedites the O2 based degredation. I dont think its a great idea to "mix it agressively either" if preparing for extended use. I think you also made reference to a "sodium". Perhaps I am hallucinating. But if - not so. It is mixed with a 0.9 solution of BAC water which is simply steril water with Benzyl alcohol added to almost 1%. This helps to keep clean and prevent pain.... It WILL feel like you were hit in the gut with a golf ball if you go steril water only, I have heard....
i have find another interesting thing in the steroid.com forum:
„If recovery is unsuccessful, HCG is continued with an adjustment in dosage and frequency as necessary until the increase in testicular volume and function have been achieved which is unlike the more typical, yet incorrect belief that HCG is only to be used for a short period of time. Once there is a plateau in the response to HCG, treatment with an FSH preparation such as human menopausal gonadotropin (HMG) or recombinant follicle stimulating hormone (rFSH) should be added at a starting dose of 75-150 IUs on alternate days.”
and i think the same!why to stop the Hcg as long as you havent see any sign yet from it?if the testicles dont get volume again,if yours libido is not up etc...i think a drug should stop only when it hit its point!
„If recovery is unsuccessful, HCG is continued with an adjustment in dosage and frequency as necessary until the increase in testicular volume and function have been achieved which is unlike the more typical, yet incorrect belief that HCG is only to be used for a short period of time. Once there is a plateau in the response to HCG, treatment with an FSH preparation such as human menopausal gonadotropin (HMG) or recombinant follicle stimulating hormone (rFSH) should be added at a starting dose of 75-150 IUs on alternate days.”
and i think the same!why to stop the Hcg as long as you havent see any sign yet from it?if the testicles dont get volume again,if yours libido is not up etc...i think a drug should stop only when it hit its point!
Have you some news since ? Still desensitized or all is came back ?
Iamnatty
Member
This person hasn't been on this forum since 2011
Ow sad… it would be interesting to know if his desensitization came back to normal.
Thanks
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