Freezing lyophilised hgh

[myskamuska]

If lyophilised HGH has been in the freezer overnight, is it still fine to use? Do you think it degraded?

 

[Ivan221106]

A dude in the forums found a couple kits he left in his closet for like 3 years, sent it in for testing and the purity had gone from roughly 98% to 96-97%.

GH doesn’t expire like food, the proteins degrade over time. The rate they degrade at depends on storage conditions.

So in the fridge (proper storage) it’ll last a long time. Without proper storage it lasts a long time too, you just lose some purity over time.

Thank you very much. I would also like to ask if, apart from the box from the vendor, I should put them in something else or directly in the fridge just in box?

 

[Thriso]

Thank you very much. I would also like to ask if, apart from the box from the vendor, I should put them in something else or directly in the fridge just in box?

Just put the box in the fridge, it'll be fine.

After recon I have a small vial case (sold for insulin/peptide vials on amazon) that I keep it in.

You don't want to pull the whole kit out each time you inject because of temp changes, but also don't want individual vials in the fridge that can get knocked around so a $10 case solves that problem.

 

[Ivan221106]

Just put the box in the fridge, it'll be fine.

After recon I have a small vial case (sold for insulin/peptide vials on amazon) that I keep it in.

You don't want to pull the whole kit out each time you inject because of temp changes, but also don't want individual vials in the fridge that can get knocked around so a $10 case solves that problem.

Thanks can I store in fridge in box for maybe more than 1 year?

Just put the box in the fridge, it'll be fine.

After recon I have a small vial case (sold for insulin/peptide vials on amazon) that I keep it in.

You don't want to pull the whole kit out each time you inject because of temp changes, but also don't want individual vials in the fridge that can get knocked around so a $10 case solves that problem.

can you send me link, thanks

 

[Thriso]

Thanks can I store in fridge in box for maybe more than 1 year?

can you send me link, thanks

Yes more than 1 year is fine.

Amazon.com

 

[Ivan221106]

Yes more than 1 year is fine.

Amazon.com

Thanks

 

[naps_for_gains]

Another option that has room to stockpile if you're like me and like to transfer the vials from the boxes immediately: Amazon.com

 

[Evolve74]

View attachment 365191

I saw this in a video once when searching for info. Its good to know

 

[Billbo98]

The commonly made error is assuming pharma-grade rhGH is in any way comparable to UGL rhGH. Real pharma/lab rhGH is carefully formulated and lyophilized with methods validated by moisture/Tg testing, strict drying temp limits to avoid meltback, aseptic conditions, and stored/transported under controlled temps.

UGL setups skip all of that. Even the most basic shit, like sterility and vacuum aren’t guaranteed, so the “normal Tg ranges” from the literature don’t transfer.

We see visible evidence of QA failure constantly, even if most don’t realize it’s not just an aesthetic issue. How often do we see a well formed puck? The common tells of amateur lyophilization are cakes pulled off the vial wall, flakes scattered around the vial (often between the stopper and vial glass), instead of one clean solidly adhered puck that’s standard in pharma vials, no matter how hard they get knocked around. That’s direct evidence of collapse/meltback and uneven drying, leaving wet, protein-heavy amorphous pockets dragging Tg down.

Another huge problem I’ve mentioned before is uncontrolled storage and transport temperatures. Those conditions are enough to drop glass transition temps like a rock, even for pharma, never mind poorly made UGL.

I’m pretty sure no one’s gong to assert exposure to uncontrolled temps in shipping isn’t common.

These vials are shipped and stored without a cold chain, and summer shipping containers can hit 150F+. When a cake gets heated above it’s glass transition temp, it goes rubbery, the cake relaxes and collapses, leftover amorphous material crystallizes faster (mannitol is notorious for this), and that crystallization pushes water into protein-rich pockets. Water plasticizes those pockets and drags glass transition temps even lower, setting up a loop where the next temp cycle of cooling then heating pushes glass transition temps down even further each time.

We see the evidence of this type of damage in anecdotal reports here every day.

Foaming on reconstitution is routinely posted about. It’s a dead giveaway of bad lyo. It means the structure is wrecked, water can’t soak in smoothly, gummy protein-rich zones form, air gets trapped, and stable bubbles form. Those gummy zones are indicative of extremely low-Tg created by poor lyophilization. Pharma doesn’t foam when reconstituted.

Then there’s endless drama here involving instant cloudiness/aggregation right after reconstitution, which users report all the time. Immediate aggregation means the protein spent time in a high-mobility state, basically at some temp well above its Tg, where aggregation ramps fast. And that’s just VISIBLE aggregation.

Janoshik’s testing shows an astonishing rate of lyophilized peptide sterility failures of around 5%. That’s literally hundreds of thousands of times higher than pharma, and it’s probably an undercount. If something as absolutely basic and essential as sterility control is that loose, lyophilization control is loose too.

So when the norm is garbage broken up pucks, foaming, often instant aggregation, meaningful sterility failures, and hot, uncontrolled shipping/storage that actively drives Tg downward, the safe assumption for unknown UGL rhGH is Tg far below the worst-case pharma scenario, easily below −15 °C in the protein-rich pockets. When process and handling are unknown, and clear evidence of shoddy manufacturing failures are norm, not exceptions, the risk-minimizing stance is to assume real-world Tg is closer to worst case scenario, not controlled lab/pharma ideals.

So condensed version don’t freeze your generic GH or peptides lol

 

[ParquetPatquet]

Recently conducted a test (in a testing group ) comparing lyophilized gh stored in freezer vs fridge. No difference in purity and dimers.

I encourage other testing groups that routinely test hgh to do the same and come to their own conclusions.

 

[Evolve74]

Recently conducted a test (in a testing group ) comparing lyophilized gh stored in freezer vs fridge. No difference in purity and dimers.

I encourage other testing groups that routinely test hgh to do the same and come to their own conclusions.

was there info on your findings you wanted to share or just tell us all you did this? lol

 

[Billbo98]

was there info on your findings you wanted to share or just tell us all you did this? lol

LMAO I would like to know these findings as well you little tease you

 

[Kralteramon]

LMAO I would like to know these findings as well you little tease you

It doesn’t matter for the relative short term. Longer term/ 1 year or more is unknown but freezing most likely will preserve your peptides longer than not.

 

[deadformat83]

It doesn’t matter for the relative short term. Longer term/ 1 year or more is unknown but freezing most likely will preserve your peptides longer than not.

 

[jonny82]

I always freeze the peptides I have in reserve, including HGH, at -20°, when I need them I take them and leave them at room temperature for 15/20 minutes and reconstitute them, then put them in the fridge