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[bigdaddyandfriends]

Will message him and ask. He has a monster gear tolerance so I wouldn't be surprised if he didn't use an AI, regularly runs 2-3g blasts

possible if he’s got a huge amount of muscle mass, which is obviously the case here if he was running that much trestolone. Hopefully he carefully monitors BP, doubt anyone would be normatensive on seems that amount of gear..

Aromatase does saturate at some point, increasing aromatizable compounds beyond that level will not result in further estrogen increase. For most people I would think that is around 750-1000mg/wk.

 

[ChemBB]

possible if he’s got a huge amount of muscle mass, which is obviously the case here if he was running that much trestolone. Hopefully he carefully monitors BP, doubt anyone would be normatensive on seems that amount of gear..

Aromatase does saturate at some point, increasing aromatizable compounds beyond that level will not result in further estrogen increase. For most people I would think that is around 750-1000mg/wk.

Looks like:
- 25mg Aromasin ED
- 160mg Telmisartan ED for BP
- 1,700 total in that meet, with +200lbs from this particular blast

 

[bigdaddyandfriends]

Looks like:
- 25mg Aromasin ED
- 160mg Telmisartan ED for BP
- 1,700 total in that meet, with +200lbs from this particular blast

View attachment 353092

Well that's proof that Asin works for trestolone. I've read in various places that it doesn't because 'it's converted to estrogen in the liver'. But liver or elsewhere, the only way any human produces estrogen is conversion of androgens via aromatase. That includes a woman's ovaries too - they have theca cells that produce androgens, which are then taken up and converted by granulosa cells which have extremely high levels of aromatase.

I don't like the 160mg telmisartan though... if it were me I'd use 80mg telmisartan or azilsartan, 20mg cilnidipine, and 12.5mg chlorthalidone. That's two tablets of Telmiheal Trio tabs per day. I briefly was using 80mg azilsartan + 40mg telmisartan (total ARB 120mg, they are molecularly different but functionally the same) and there was no further significant drop in BP, but I wouldn't be surprised if it elevated my serum potassium levels more.

I've been using the Telmiheal Trio and it is fantastic, and very inexpensive - I just ordered a few more boxes. Two tabs a day and one can basically forget about your BP and serum potassium.

And damn 1700 lbs that's crazy! I'm definitely far on the bodybuilding end of the spectrum so don't lift particularly heavy and use machines/cables almost exclusively, except for some dumbbell shoulder and arm work.

 

[ChemBB]

I've been using the Telmiheal Trio and it is fantastic, and very inexpensive - I just ordered a few more boxes. Two tabs a day and one can basically forget about your BP and serum potassium.

Have been interested in trying this. I talk to my cardiologist in about a week, hopefully can get some of these meds switched.

 

[AbsoluteKnight]

Well that's proof that Asin works for trestolone. I've read in various places that it doesn't because 'it's converted to estrogen in the liver'. But liver or elsewhere, the only way any human produces estrogen is conversion of androgens via aromatase. That includes a woman's ovaries too - they have theca cells that produce androgens, which are then taken up and converted by granulosa cells which have extremely high levels of aromatase.

I don't like the 160mg telmisartan though... if it were me I'd use 80mg telmisartan or azilsartan, 20mg cilnidipine, and 12.5mg chlorthalidone. That's two tablets of Telmiheal Trio tabs per day. I briefly was using 80mg azilsartan + 40mg telmisartan (total ARB 120mg, they are molecularly different but functionally the same) and there was no further significant drop in BP, but I wouldn't be surprised if it elevated my serum potassium levels more.

I've been using the Telmiheal Trio and it is fantastic, and very inexpensive - I just ordered a few more boxes. Two tabs a day and one can basically forget about your BP and serum potassium.

And damn 1700 lbs that's crazy! I'm definitely far on the bodybuilding end of the spectrum so don't lift particularly heavy and use machines/cables almost exclusively, except for some dumbbell shoulder and arm work.

Telmiheal trio?? Tell me more about this where at?

 

[bigdaddyandfriends]

Telmiheal trio?? Tell me more about this where at?

PCT24x7.. it’s on his latest price list. Can’t recommend it highly enough… it has the top theee BP drugs in each class (ARB, CCB, and diuretic). It’s thiazide type diuretic so won’t exacerbate the hyperkalemia from ARB, unlike MCR inhibitors like aldactone and eplererone.

 

[AbsoluteKnight]

PCT24x7.. it’s on his latest price list. Can’t recommend it highly enough… it has the top theee BP drugs in each class (ARB, CCB, and diuretic). It’s thiazide type diuretic so won’t exacerbate the hyperkalemia from ARB, unlike MCR inhibitors like aldactone and eplererone.

That sounds nifty especially cus I recently got hctz and ended up not using it because it apparently makes you less insulin sensitive taking about 30mg teli rn what would you recommend would be a good dose for that one ?

 

[bigdaddyandfriends]

That sounds nifty especially cus I recently got hctz and ended up not using it because it apparently makes you less insulin sensitive taking about 30mg teli rn what would you recommend would be a good dose for that one ?

I don’t recommend HCTZ for that exact reason.

Indapamide 2.5mg or chlorthalidone 12.5mg/day (smallest tab typically 25mg) are the best two similar drugs that do not mess with insulin sensitivity and have a better side effect profile overall. Only real side effect - other than dehydration which is common to all diuretics - is low potassium which nicely counters the higher potassium levels in most ARB users.

If not using an ARB, then eplererone. Men don’t typically use spironolactone because it cross reacts with the AR, acting as an antandrogen, although for those of us that are significantly enhanced it is likely insignificant. it is prescribed commonly for women to help androgen-associated acne.

 

[AbsoluteKnight]

I don’t recommend HCTZ for that exact reason.

Indapamide 2.5mg or chlorthalidone 12.5mg/day (smallest tab typically 25mg) are the best two similar drugs that do not mess with insulin sensitivity and have a better side effect profile overall. Only real side effect - other than dehydration which is common to all diuretics - is low potassium which nicely counters the higher potassium levels in most ARB users.

If not using an ARB, then eplererone. Men don’t typically use spironolactone because it cross reacts with the AR, acting as an antandrogen, although for those of us that are significantly enhanced it is likely insignificant. it is prescribed commonly for women to help androgen-associated acne.

But seems the one you mentioned is a nice all in one

 

[professionaldyel]

Either as much Trestolone as I could handle (have done 300mg before, so maybe 500-700mg), or 2g Test.

Combined with:
- 50-100mg Anavar
- 10iu GH
- 10-20iu Slin

Maybe throw in 400-600 Mast E.
I did 1g Test + 500 Mast before and that was pretty solid.

Have a competitive PL friend who's run up to 1g Trest.

View attachment 352774

What was your MENT cycle? Im running OEP's at 100mg/wk and ive had 0 sides besides RHR and BP increasing which is now fixed with 5mg Nebivolol. I fucking love MENT 4 weeks in.

 

[ChemBB]

What was your MENT cycle? Im running OEP's at 100mg/wk and ive had 0 sides besides RHR and BP increasing which is now fixed with 5mg Nebivolol. I fucking love MENT 4 weeks in.

I started at 150mg Trest D and went up to 300mg Trest D over a few months because I didn't have any sides.

Wasn't using any Test with it, was also taking 35mg Var daily

I fucking love MENT 4 weeks in.

Yeah, it's my favorite compound -- I just wish I could reliably source long ester Trest at a decent price. I don't like short esters because of blood fluctuations, even if pinning daily.

 

[Jesintn]

Ate there any studies measuring estrone levels for equipoise , at different doses, say 150, 300, 450, and 600 mgs ?

Estrone causes collagen tissue production to stimulate ? , skin elasticity, and memory protection

 

[Eddie.]

Ate there any studies measuring estrone levels for equipoise , at different doses, say 150, 300, 450, and 600 mgs ?

Estrone causes collagen tissue production to stimulate ? , skin elasticity, and memory protection

I doubt it's possible to do it. Each person aromatise differently on a given dose, what stands for e2 i guess stands for e1 as well.

 

[bigdaddyandfriends]

Ate there any studies measuring estrone levels for equipoise , at different doses, say 150, 300, 450, and 600 mgs ?

Estrone causes collagen tissue production to stimulate ? , skin elasticity, and memory protection

I still say EQ cannot convert directly to estrone, only estradiol because it has a 17-hydroxyl group, not a 17-keto group. Aromatase only modifies the A-ring, it does NOT do anything at C17 which is on the opposite side of the steroid molecule. And there’s no other enzyme besides aromatase to produce estrogens of any type in the body - both in women and men, they are all converted by aromatase from androgens.

Now once EQ is converted to estradiol, it can be converted again into estrone, and similarly estrone can be converted to estradiol, via 17β-HSD enzymes, which are expressed to varying degrees in different tissues. So estrone is both a metabolite and precursor to estradiol and vice versa - normally estrone acts as a reservoir for estradiol production - except in post-menopausal women when it becomes the dominant estrogen (from adrenal DHEA) and as you likely know they typically develop major low estrogen symptoms, including male body fat distribution, hot flashes, accelerated ASCVD, body hair growth, low energy/libido, aches and pains, etc - that’s without HRT of course.

Some, maybe all of the Δ1-testosterone group may inhibit 17β-HSD1, in different people to varying degrees, which would cause a relative rise in E1 and relative decrease in E2. E2 is up to 100x as potent as E1 at receptor transactivation, so it doesn’t take much extra E1 to have an inhibitory effect on E2 - it basically acts as a competitive inhibitor when attached to an ER.

And I am aware of lab results showing high E1 in EQ users. Either it’s from excessive 17β-HSD1 inhibition in those people, or they have some new enzyme yet to be discovered.

 

[Photon]

Now once EQ is converted to estradiol, it can be converted again into estrone, and similarly estrone can be converted to estradiol, via 17β-HSD enzymes, which are expressed to varying degrees in different tissues.

I'll post my Estrone LCMS when I get it, eta is probably 3-4 weeks.

Post in thread 'Using estradiol injection to allow for low test cycles'

Oct 8, 2025

E2 on 1g Test/EQ


2 weeks of 1mg/week e2 cyp + 2 weeks of .6mg/week of e2cyp
trough

• Photon

• 

 

[Photon]

I'll post my Estrone LCMS when I get it, eta is probably 3-4 weeks.

Post in thread 'Using estradiol injection to allow for low test cycles'

Oct 8, 2025

E2 on 1g Test/EQ


2 weeks of 1mg/week e2 cyp + 2 weeks of .6mg/week of e2cyp
trough

• Photon

• 

@dinfar1337 @Sampei
Any theory? @bigdaddyandfriends

Looks like both my E1 and E2 are low on EQ lol.
I guess that's a blessing.
Incoming daily dbol for next cycle..

 

[dinfar1337]

Looks like both my E1 and E2 are low on EQ lol.

highly likely eq outcompeting test at the aromatese sites. can speed slowed aromatese up by adding dianabol in or upping testosterone.

you would probably need to lower eq or up test. or run higher dbol to outcompete the eq at receptor site level. this is inhibition of aromatese, not e2>e1 conversion problem

 

[Photon]

highly likely eq outcompeting test at the aromatese receptor. can speed slowed aromatese up by adding dianabol in or upping testosterone.

you would probably need to lower eq or up test. or run higher dbol to outcompete the eq at receptor site level. this is inhibition of aromatese, not e2>e1 conversion problem

Already on 1g TD / 1g EQ lol
e2 standalone test


4 weeks later, with e2 injected
e1+e2 test



I'm considering 20dbol a day vs injecting e2.

 

[dinfar1337]

Already on 1g TD / 1g EQ lol
e2 standalone test
View attachment 354883

4 weeks later, with e2 injected
e1+e2 test
View attachment 354881
View attachment 354882

I'm considering 20dbol a day vs injecting e2.

thats pg/ml?

 

[Photon]

thats pg/ml?

e2 sensitive