Your letrozole is complete dog shit, I ve been taking 2.5 mg/day of it for moths and still my e2 blood work came to be 28.9 Pg/ml E2.
With that dosage it should have been sigle digit E2 levels.
Btw I m not taking any PED (no testosterone or anything like that , only AI and HGH)
this is the final proof that you products are utter dog shit. I have every proof to demonstrate you I'm not kidding, I ve been ordering products from them for over a year now and only today I had the final confrirm of their untrustworthiness
You showed a result of 106.4 pmol/L – that’s within the normal male range, not high.
My first question is – what was your E2 level before, and why are you even using aromatase inhibitors if you’re not taking testosterone? What’s the reason behind that?
Secondly, I’ve honestly never seen anyone take 2.5 mg of letrozole every day. That’s an extremely high dose — unnecessary even for guys on heavy testosterone cycles — and you said you’re not using testosterone at all.
That got me thinking – what actually happens when someone uses such high doses? Here’s what I found:
PARADOXICAL INCREASE OF E2 ON HIGH DOSES OF LETROZOLE
This is officially documented in clinical studies and medical literature.
The paradox happens because of compensatory regulation of the HPG axis and aromatase expression:
• Sharp drop in estradiol → increase in gonadotropins → increased androgen synthesis
• More androgens → more substrate for aromatization → E2 may rise again
A complete “zero” estradiol level is physiologically impossible.
Where estradiol comes from in men:
• Aromatization of testosterone and androstenedione
• Conversion in adipose (fat) tissue
• Smaller production in bones, brain, and Leydig cells
Even 99% aromatase inhibition still leaves 1% enzyme activity, which is enough to keep E2 at 5–20 pg/mL.
Non-aromatase pathways that can still raise E2:
• STS (steroid sulfatase) – converts circulating estrone sulfate (E1S) → estrone (E1) → estradiol
• 17β-HSD1 – converts estrone → estradiol without aromatase
There’s also evidence that massive aromatase blockade increases CYP19A1 gene expression – that’s the gene encoding aromatase. More CYP19A1 = more aromatization capacity.
The male endocrine system resists “zero estradiol”
Because E2 affects many vital functions:
• Bone health
• Libido
• Lipid balance
• Cardiovascular protection
So, when you block aromatase too hard, the body compensates by:
• Upregulating CYP19A1 (aromatase gene)
• Increasing E2 receptor sensitivity
• Boosting local aromatization in tissues like the brain
That’s why E2 never truly hits zero, no matter what inhibitor you use.
While digging into this, I found multiple studies showing that even with such high doses, you might not end up with extremely low readings — and there are many biological reasons for that.
If you genuinely want to prove our product is “empty,” just do it the proper way as everyone does on this forum:
Send your tablets to a lab test (for example, Janoshik) and post the result here.
You’ll also earn €200 in store credit from us for that test.
It’s simple, transparent, and will give everyone a clear answer.