Blood Pressure

[Ghoul]

I got Cilnidipine in from India.
I grabbed 150 tablets, all nicely blister packed. From what I can tell, should be about 2 weeks before full impact combined with telemarstin

Working great for me!

Was on Telm/Amlodipine 40/10. Now Telm/Cilnidipine 40/10.

In theory I should need 20mg Cilnipidine for the same BP reduction as 10mg Amlodipine, but after weeks my BP has dropped a couple more points, and my resting heart rate has dropped by 3 beats.

On the "feels" front, my background anxiety level has dropped (I feel calmer, like a low dose propranolol) and I'm sleeping better per my sleep tracker,

I'm considering dropping Telm to 20mg, and increasing Cilnipidine to 20mg, to get more of the sympathetic adrenaline release blocking I seem to be benefitting greatly from, to drop RHR more, perhaps sleep even better, while keeping BP at current levels.

Also, although I didn't notice edema from the amlodipine before, my shoes are looser, and my face a little less puffy, so it looks like I had a little water retention that the Cilnipidine has reduced.

 

[jasonsta]

I was prescribed Valsartan 80 / HCTZ 12.5 to take in the morning.
I’d like to add Telmisartan 40 in the evening.
Is there any issue with taking two ARBs, or even two calcium channel blockers — for example, Lercanidipine 5 mg in the morning and Amlodipine 5 mg in the evening?
All of this is mainly for logistical convenience
@Ghoul please

 

[Ghoul]

I was prescribed Valsartan 80 / HCTZ 12.5 to take in the morning.
I’d like to add Telmisartan 40 in the evening.
Is there any issue with taking two ARBs, or even two calcium channel blockers — for example, Lercanidipine 5 mg in the morning and Amlodipine 5 mg in the evening?
All of this is mainly for logistical convenience

Yes. It's never advisable to use two same-class hypertension meds. The same way a low dose of two different class meds will synergistically amplify blood pressure improvement while reducing side effects vs a higher dose of either one used singularly, two same class meds, generally speaking, synergistically amplify side effects while each becomes less effective at lowering BP because their mechanisms of action overlap.

These meds are super cheap and easy to access with an online prescription or via India, so you should be able to dial in the protocol that's perfect for
you.

You can even get Telm/Cilnipidine/diuretic combo tabs

 

[jasonsta]

Yes. It's never advisable to use two same-class hypertension meds. The same way a low dose of two different class meds will synergistically amplify blood pressure improvement while reducing side effects vs a higher dose of either one used singularly, two same class meds, generally speaking, synergistically amplify side effects while each becomes less effective at lowering BP because their mechanisms of action overlap.

These meds are super cheap and easy to access with an online prescription or via India, so you should be able to dial in the protocol that's perfect for
you.

You can even get Telm/Cilnipidine/diuretic combo tabs

View attachment 325096

Thank you very much:

I know, but unfortunately it's impossible to deliver to France via India.

 

[Ghoul]

Thank you very much:

I know, but unfortunately it's impossible to deliver to France via India.

Oh shit 1000$ for a cycle that is mostly a permanent and France has mostly free healthcare so you can get it prescribed from a specialist.

Yeah poor guy... No wait,

Oh wait if only France was one of the few country in Europe that can receive packages from India easily...

According to @Sampei it's easy to get India meds in France. Maybe he can help.

 

[nerdwithmuscles]

This thread saved my blood pressure. I was at 145/95 and trying all sorts of natural supplements, and also tried Telmisartan up to 80mg and was only seeing minimal improvement.

I switched to Telmisartan 40mg/Amlodipine 5mg and kept in some TMG and my blood pressure is now consistently under 120/80.

Appreciate all your knowledge folks.

 

[BamaCrazy]

This thread saved my blood pressure. I was at 145/95 and trying all sorts of natural supplements, and also tried Telmisartan up to 80mg and was only seeing minimal improvement.

I switched to Telmisartan 40mg/Amlodipine 5mg and kept in some TMG and my blood pressure is now consistently under 120/80.

Appreciate all your knowledge folks.

That’s great news. Keeping BP under control is one of the smartest things we can do for our health.

 

[BP_6]

That’s great news. Keeping BP under control is one of the smartest things we can do for our health.

I can attest I have some permanent kidney damage because of not taking care of my blood pressure for many years. It is so, so important.

 

[rockyraccoon]

I can attest I have some permanent kidney damage because of not taking care of my blood pressure for many years. It is so, so important.

Check out SS-31. Might help you fix some things.

SS-31, a Mitochondria-Targeting Peptide, Ameliorates Kidney Disease - PMC

Mitochondria are essential for eukaryotic cell activity and function, and their dysfunction is associated with the development and progression of renal diseases. In recent years, there has been a rapid development in mitochondria-targeting ...

pmc.ncbi.nlm.nih.gov

 

[Ateam2023]

Check out SS-31. Might help you fix some things.

SS-31, a Mitochondria-Targeting Peptide, Ameliorates Kidney Disease - PMC

Mitochondria are essential for eukaryotic cell activity and function, and their dysfunction is associated with the development and progression of renal diseases. In recent years, there has been a rapid development in mitochondria-targeting ...

pmc.ncbi.nlm.nih.gov

that was an Awesome read , thank you,,

 

[espresso123]

So whats your experience based on stacking Telmisartan + Amlodipine vs Telmi + Clonidine ?

By nature I am on the "higher" end of normal RR, on gear, with telmi I am also on the higher end of "normal" RR, but not always in the perfect range.

Consindering a long term longevity, what would be your recommendation / facts?
Will consult my physician regarding this when he finally is back to business.. but willing to get some prior first hand pros/cons regarding that prior.

Thanks in advance!

 

[Photon]

So whats your experience based on stacking Telmisartan + Amlodipine vs Telmi + Clonidine ?

Cilnidipine is not the same as Clonidine.
It's also not approved in EU/US so your doctor cant prescribe it.
If you want it, you can get from India pharma.

 

[espresso123]

Cilnidipine is not the same as Clonidine.
It's also not approved in EU/US so your doctor cant prescribe it.
If you want it, you can get from India pharma.

Thanks for clarifying, I was confused by the "similarity" of the substances name.

However, Id rely on what I can get my hands on easily on prescription in the EU regarding my question.

No issues getting anything on script for me..

 

[Photon]

Since Cilnidipine isn't available, your best choice is naturally Telm + Amlo..

 

[Sampei]

Since Cilnidipine isn't available, your best choice is naturally Telm + Amlo..

Nope best choice telmi + Lercanidipine

 

[VakarianSK]

Nope best choice telmi + Lercanidipine

Curious to hear your thoughts on why you prefer Lercanidipine over Cilnidipine?

 

[Sampei]

Curious to hear your thoughts on why you prefer Lercanidipine over Cilnidipine?

I don't.. he was asking for something that is available in the EU without going through India pharma and he said telmi + amlodipine is the best combo available but it's not true. Lercanidipine is available in Europe and USA and it has a lot less chances to give edema compared to amlodipine.

Cilnidipine is superior to both but not easily available

 

[BP_6]

My current blood pressure protocol is pretty strong as I need to keep mine in the lower range from past damage.

80 mg telmisartan or azilsartan "The az lowers it just a bit more but is more expensive until the US generic version is available.

10mg bystolic. Thought about Cilnidpine, but sticking with bystolic since my insurance gives me a very good price and it works well for me.

25mg chlorthalidone "Better than HCTZ with a sold half life" a lot of people worry about the thiazide diuretics, but in reality they only act like a diuretic and you pee more the first week or two on them. After you adjust, peeing returns to normal. Their main reason for use is they also have a blood vessel relaxing effect.

Have done a lot of self experimenting and working with my doctor and this is the best so far for me.

 

[Photon]

I don't.. he was asking for something that is available in the EU without going through India pharma and he said telmi + amlodipine is the best combo available but it's not true. Lercanidipine is available in Europe and USA and it has a lot less chances to give edema compared to amlodipine.

Cilnidipine is superior to both but not easily available

Not approved in US..as expected..

 

[BP_6]

Not approved in US..as expected..

Apparently it is not approved because the manufacturer doesn't want to spend the insane amount of money required to get FDA approval. They have over 100 studies. However, they literally want 1000's, and of course the full FDA trial process.