Blood Pressure

[Ghoul]

Does CCB reduce RHR like Beta-blockers?

No, different mechanism.

Amlodipine is an L channel calcium blocker.

Cilnipidine is an L and N blocker.

Blocking N lowers levels of noradrenaline.

Noradrenaline stimulates alpha receptors in the heart, increasing heart rate.

Unlike intermittently released adrenaline, noradrenaline is continuously released, so reducing it lowers RHR.

 

[BamaCrazy]

I should've used a more recent reference.

Quadro is ongoing. Quartet continues to be analyzed and mentioned but I don't know what the holdup is with that one).

A single tablet with 4 blood pressure-lowering drugs can be more effective than taking 3 drugs in separate pills

Your access to the latest cardiovascular news, science, tools and resources.

www.escardio.org

The European Society of Cardiology conference late last year had a lot of news regarding combinations.

The other big news was what seems like the final nail in the coffin of the BP med timing debate, an argument seemingly going on forever:

Take it whenever, just take it.

Late-Breaking Hypertension Studies Address Medication Timing, Benefits of Combination Pills, More - American College of Cardiology

www.acc.org

The difference between the triple and the quadruple is huge in that study.

 

[Sampei]

No, different mechanism.

Amlodipine is an L channel calcium blocker.

Cilnipidine is an L and N blocker.

Blocking N lowers levels of noradrenaline.

Noradrenaline stimulates alpha receptors in the heart, increasing heart rate.

Unlike intermittently released adrenaline, noradrenaline is continuously released, so reducing it lowers RHR.

Why the fuck we don't have that new generation of CCB?

 

[john87412]

No, different mechanism.

Amlodipine is an L channel calcium blocker.

Cilnipidine is an L and N blocker.

Blocking N lowers levels of noradrenaline.

Noradrenaline stimulates alpha receptors in the heart, increasing heart rate.

Unlike intermittently released adrenaline, noradrenaline is continuously released, so reducing it lowers RHR.

Whats ur dc ?

 

[Ghoul]

Whats ur dc ?

dc?

 

[john87412]

dc?

discord

 

[Ghoul]

discord

DM me here,

 

[john87412]

DM me here,

No privileges , whats ur protonmail ?

 

[Ghoul]

Got it go ahead and delete.

 

[john87412]

Got it go ahead and delete.

Ok dm me on there

 

[Ghoul]

Ok dm me on there

Done

 

[john87412]

Done

Check ur proton

 

[Ex0shear]

The other big news was what seems like the final nail in the coffin of the BP med timing debate, an argument seemingly going on forever:

Take it whenever, just take it.

Yeah, I don't know, HCTZ has to be an exception. You take that shit at bedtime and if you aren't waking up to piss at least 3 times, you're most likely not hydrated enough.

 

[Ghoul]

Yeah, I don't know, HCTZ has to be an exception. You take that shit at bedtime and if you aren't waking up to piss at least 3 times, you're most likely not hydrated enough.

Let me expand on that:

The question that answer is for is:

"What's the best time of day to take BP Meds to work best for their primary purpose, reducing heart attacks and strokes?"

And the most current evidence based answer is:

"Whatever time works for you, the main thing is that you take them consistently."

 

[Ex0shear]

Let me expand on that:

The question that answer is for is:

"What's the best time of day to take BP Meds to work best for their primary purpose, reducing heart attacks and strokes?"

And the most current evidence based answer is:

"Whatever time works for you, the main thing is that you take them consistently."

Gotcha. I only pointed it out because at some point I did start taking all BP meds at bedtime based on my PCP's recommendation. Four straight nights of almost no sleep and mostly pissing was enough to call it quits.

 

[Ghoul]

Gotcha. I only pointed it out because at some point I did start taking all BP meds at bedtime based on my PCP's recommendation. Four straight nights of almost no sleep and mostly pissing was enough to call it quits.

Yeah, basically you can take them at your convenience, or like you said, to minimize having to deal with any sides, without worrying about increasing your risk of some catastrophic outcome.

 

[Bigoldguy]

Yeah, basically you can take them at your convenience, or like you said, to minimize having to deal with any sides, without worrying about increasing your risk of some catastrophic outcome.

I take mine first thing with breakfast...seems to keep everything lvl throughout the day

 

[Ghoul]

I take mine first thing with breakfast...seems to keep everything lvl throughout the day

Trying to get to ideal BP while avoiding diuretics or beta blockers, since both have sides and some potential negative effects.

Looks like ARB/CCB is the best for long term use, if you can make it work.

Just saw docs are even being advised to shift patients from ACE to ARB now since
ACE increases lung cancer risk in non smokers.

 

[BamaCrazy]

Gotcha. I only pointed it out because at some point I did start taking all BP meds at bedtime based on my PCP's recommendation. Four straight nights of almost no sleep and mostly pissing was enough to call it quits.

Nighttime works well for me for Telmisartan and Cilnidipine. I would avoid taking a diuretic at night for the obvious reasons. I struggle to sleep as it is, the last thing I need is to be getting up to pee multiple times a night.

I take Nebivolol in the morning but I think I’m going to start taking it after I go to the gym in the morning. It’s keeping my heart rate down when I need it to increase at least some.

 

[Ghoul]

Nighttime works well for me for Telmisartan and Cilnidipine. I would avoid taking a diuretic at night for the obvious reasons. I struggle to sleep as it is, the last thing I need is to be getting up to pee multiple times a night.

I take Nebivolol in the morning but I think I’m going to start taking it after I go to the gym in the morning. It’s keeping my heart rate down when I need it to increase at least some.

Which brand of Cilnipidine did you end up receiving?