Beta-2 Hyperresponder?

[Peptilda]

My resting heart rate is 65 bpm

I started retatrutide and tesofensine dosing
3 days in my saturation is 3.5 mg for retatrutide (5 mg initial dose) and 4.5 mg tesofensine (1 mg, 1 mg, 1 mg, 2 mg, daily doses to get concentration to peak levels at a .5 mg daily dose)
Heart rate resting was 90 bpm

Introduced Clen, 40 minutes after i swallowed the Clen my heart rate went from 90 bpm to 126 bpm
What was the dose? ~25 mcg, i split a 40 mcg tablet in half, and although the split wasnt perfect it was not a significant disparity, it was mostly just a meniscus like edge so maybe at most 10-20% more on the half-tab i took than the other

Its only been ~2 hours since i took it but im getting some pretty signficant side effects, getting that jittery hyperaware mental clarity etc, funnily enough the headache i had from tesofensine actually went away, could be due to baroreflex activation of clenbuterol causing vasodilation

These are all true resting metrics, laying down for atleast 5 minutes since any form of activity with controlled full breathing

 

[Photon]

My resting heart rate is 65 bpm

I started retatrutide and tesofensine dosing
3 days in my saturation is 3.5 mg for retatrutide (5 mg initial dose) and 4.5 mg tesofensine (1 mg, 1 mg, 1 mg, 2 mg, daily doses to get concentration to peak levels at a .5 mg daily dose)
Heart rate resting was 90 bpm

Introduced Clen, 40 minutes after i swallowed the Clen my heart rate went from 90 bpm to 126 bpm
What was the dose? ~25 mcg, i split a 40 mcg tablet in half, and although the split wasnt perfect it was not a significant disparity, it was mostly just a meniscus like edge so maybe at most 10-20% more on the half-tab i took than the other

Its only been ~2 hours since i took it but im getting some pretty signficant side effects, getting that jittery hyperaware mental clarity etc, funnily enough the headache i had from tesofensine actually went away, could be due to baroreflex activation of clenbuterol causing vasodilation

These are all true resting metrics, laying down for atleast 5 minutes since any form of activity with controlled full breathing

what clen
from where?

the rhr increase from reta is common

 

[Peptilda]

what clen
from where?

the rhr increase from reta is common

Hepius Clen from WWB, i know the RHR increase is common for reta and tesofensine, the jump in my heart rate from the clenbuterol was extremely high from that ive seen in research studies

 

[IndividualMan]

go for pharma clen. UGL clen can be overdosed up to 3x (we saw some 5x overdoses but that was only once or twice) and sometimes they are completely empty.

Any pharma clen is better than UGL clen. maybe look to indian vendors.
Also, you are on 3 compounds to raise RHR. some of which compound in potency. your RHR is gonna be high.

 

[Photon]

Hepius Clen from WWB, i know the RHR increase is common for reta and tesofensine, the jump in my heart rate from the clenbuterol was extremely high from that ive seen in research studies

Yer playing russian roulette with each dose.
Probably that's why.
A wrong dose could be a visit to the ER.

 

[frenexen]

The whole reason tesofensine works is because its long half-life allows for steady accumulation. Front-loading it is a terrible idea. Combine it with clen and I'm not surprised this happened.

It would be like front-loading GLPs. There is a reason you don't do it.

 

[Athleticfreak]

4.5 mg tesofensine (1 mg, 1 mg, 1 mg, 2 mg, daily doses to get concentration to peak levels at a .5 mg daily dose)

WTF

 

[Peptilda]

go for pharma clen. UGL clen can be overdosed up to 3x (we saw some 5x overdoses but that was only once or twice) and sometimes they are completely empty.

Any pharma clen is better than UGL clen. maybe look to indian vendors.
Also, you are on 3 compounds to raise RHR. some of which compound in potency. your RHR is gonna be high.

I know im on 3 compounds that raise heart rate, The thing i was pointing to was a disproportionate response relative to normal response in studies and from what ive seen in terms of anecdotes, nothing about the pharmacology of any of these would indicate compounding potency with each other (if you are referring to synergy (x=100, y=75, x+y=200)) Endogenous norepinephrine does target beta-2 AR and beta-1 AR downstream but clenbuterol has stronger activation of beta-2 AR and its beta-1 spill over is stronger as well, so effects would be at best additive (and slightly redundant if clen dose maxxed out beta-2 receptors)
the point of the post wasnt being concerned about my heart rate, i popped the other half about 8 hours after initial dose and my heart rate was 140 resting, heart rate differential drop off means i was probably at peak receptor occupancy.
For further reference on my stimulant response at 180 lbs bodyweight my resting heart rate gets from 65 bpm to 120+ bpm from ~300 mg of caffeine and 20 mg of adderall, and around 110-120 from 800 mg of caffeine
only reason why i didnt go with pharma clen is cuz i was already eating a 50 dollar shipping fee for the reta and tesofensine so i figured i might as well slap it on there, whenever i try to use IndiaMart i have 60 fucking jeets spamming my phone while im tryna sleep

 

[Peptilda]

The whole reason tesofensine works is because its long half-life allows for steady accumulation. Front-loading it is a terrible idea. Combine it with clen and I'm not surprised this happened.

It would be like front-loading GLPs. There is a reason you don't do it.

the reason tesofensine works is because its pharmacodynamically similar to ADHD medication, DRI, NRI, and SRI and neurologically alters reward system signaling. Frontloading would only be an issue during chronic usage at a specific prescription dose. Frontloading is better for my specific scenario since it allows for rapid sustained levels and i use things like adderall (obviously not taking currently lol), its in no way similar to frontloading a GLP, taking .5 mg daily and slowly moving up to a sustained level gives you ~2 weeks of effects at accumulating levels, once youre at sustained levels due to halflifes your response curve would be the exact same as someone who frontloaded early, so instead im getting stronger appetite suppression, in a significantly better mood, feel more motivated, and the only thing that change is I have an extra ~week of sustained level exposure than someone who started at .5 mg/day

 

[Peptilda]

oh also the 140 bpm resting from the extra 20 mcg did not cause any heart issues outside of the chronic tachycardia itself, no chest pain, no tremors, jitters went away after around an hour and a half, regular heart rhythm, i could still feel a physical difference between when i had an acute adrenaline secretion due to actual fight or flight response (significantly stronger, my FoF has always been very intense, like id get to the point where my legs feel light and shaky and i needed to sit down just from confrontation initiating and my heart would race for several minutes even if the confrontation was over)

 

[frenexen]

the reason tesofensine works is because its pharmacodynamically similar to ADHD medication, DRI, NRI, and SRI and neurologically alters reward system signaling. Frontloading would only be an issue during chronic usage at a specific prescription dose. Frontloading is better for my specific scenario since it allows for rapid sustained levels and i use things like adderall (obviously not taking currently lol), its in no way similar to frontloading a GLP, taking .5 mg daily and slowly moving up to a sustained level gives you ~2 weeks of effects at accumulating levels, once youre at sustained levels due to halflifes your response curve would be the exact same as someone who frontloaded early, so instead im getting stronger appetite suppression, in a significantly better mood, feel more motivated, and the only thing that change is I have an extra ~week of sustained level exposure than someone who started at .5 mg/day

No, it's not pharmacodynamically similar to adderall. You're talking about a ~12 hour half life vs. a ~9 day half life. Also, not sure why you're saying 2 weeks, as 5 half lives are required for steady state. This wouldn't apply to either tesofensine or retatrutide. Tesofensine already causes significant increases in HR without frontloading. Neurotransmitters downregulate over time, just as the body adapts to delayed gastric emptying over time.

Frontload a glp and you risk gastric paralysis, front load tesofensine and experience a rapid HR from both DRI and NRI. I'm not sure how you're claiming it's any different? Why do you think official glp dosing protocols call for an increase every month?

 

[Elektrobot]

My resting heart rate is 65 bpm

I started retatrutide and tesofensine dosing
3 days in my saturation is 3.5 mg for retatrutide (5 mg initial dose) and 4.5 mg tesofensine (1 mg, 1 mg, 1 mg, 2 mg, daily doses to get concentration to peak levels at a .5 mg daily dose)
Heart rate resting was 90 bpm

Introduced Clen, 40 minutes after i swallowed the Clen my heart rate went from 90 bpm to 126 bpm
What was the dose? ~25 mcg, i split a 40 mcg tablet in half, and although the split wasnt perfect it was not a significant disparity, it was mostly just a meniscus like edge so maybe at most 10-20% more on the half-tab i took than the other

Its only been ~2 hours since i took it but im getting some pretty signficant side effects, getting that jittery hyperaware mental clarity etc, funnily enough the headache i had from tesofensine actually went away, could be due to baroreflex activation of clenbuterol causing vasodilation

These are all true resting metrics, laying down for atleast 5 minutes since any form of activity with controlled full breathing

Go read the new member rules and etiquette

Make your new member introduction post in the appropriate area like you are supposed to.

When you write it, tell us about yourself. Your age, height, weight, bodyfat%, your training, your food plan, your goals..... how did you decide to use clen and reta? What bloodwork and cardiac testing have you done?

 

[Mongo966]

go for pharma clen. UGL clen can be overdosed up to 3x (we saw some 5x overdoses but that was only once or twice) and sometimes they are completely empty.

Any pharma clen is better than UGL clen. maybe look to indian vendors.
Also, you are on 3 compounds to raise RHR. some of which compound in potency. your RHR is gonna be high.

I've read about enough horrific UGL clen lab test results to turn me right off of it.
Imagine deciding to try clen, buying it from a trusted UGL and nobody realizes that the pack you bought has a bunch of tabs in it that are hot as fuck. So your first time taking clen you neck a couple of 200mcg tabs that are only supposed to be 40mcg each and it kills you.

It isn't worth it. I'm willing to take certain risks in this space but I'm not willing to risk overdosing on asthma medication and vibrating myself to death.
Seriously, fuck that altogether.

 

[IndividualMan]

I know im on 3 compounds that raise heart rate, The thing i was pointing to was a disproportionate response relative to normal response in studies and from what ive seen in terms of anecdotes, nothing about the pharmacology of any of these would indicate compounding potency with each other (if you are referring to synergy (x=100, y=75, x+y=200)) Endogenous norepinephrine does target beta-2 AR and beta-1 AR downstream but clenbuterol has stronger activation of beta-2 AR and its beta-1 spill over is stronger as well, so effects would be at best additive (and slightly redundant if clen dose maxxed out beta-2 receptors)
the point of the post wasnt being concerned about my heart rate, i popped the other half about 8 hours after initial dose and my heart rate was 140 resting, heart rate differential drop off means i was probably at peak receptor occupancy.
For further reference on my stimulant response at 180 lbs bodyweight my resting heart rate gets from 65 bpm to 120+ bpm from ~300 mg of caffeine and 20 mg of adderall, and around 110-120 from 800 mg of caffeine
only reason why i didnt go with pharma clen is cuz i was already eating a 50 dollar shipping fee for the reta and tesofensine so i figured i might as well slap it on there, whenever i try to use IndiaMart i have 60 fucking jeets spamming my phone while im tryna sleep

all stimulants have a somewhat compounding effect.
300mg caffeine raises my RHR by 5 BPM
ADHD meds (whichever dosage I may or may not be taking) raise my RHR by 5 bpm.
together they raise my RHR by 12-14bpm.
add in tesofensine at around 500mcg and my heartrate is up 20+BPM

anyways, you, good sir need to be doing your goddamn cardio.
And you do need to be concerned for your heart rate.
Your heart seems to be in horrible condition if your pulse spikes like that off just caffeine and ADHD meds. or just stop taking all these things that spike your pulse just to avoid being in a caloric deficit for an extra 2-3 months.