accutane protocol questions

[john123321]

Hello, I have been an avid PEDs researcher and I cannot wait to start. However, I do have a predisposition to acne that doesn't seem to go away so I will be running Accutane on a very high caloric deficit to both get lean and reduce the size of sebaceous glands. Also theres the benefit of looking good too

Please criticize my protocol as harshly as you can. I would rather hear mean words than make terrible mistakes.

Target cumulative dose: 10,000mg
Dosing/Titration: 20mg daily for the first two weeks, then 40mg daily for the next two, and 80 for the rest of treatment.
Bloods: Probably going to do one blood test before, and one three months in
Time frame: I would say it would take about five months or so
Ancillaries: 5g combined EPA + DHA, Glutathione, TUDCA (have to figure out the dosing), 100mg melatonin nightly. I have to do more research but if BDNF/CREB signaling is impeded I might add in ACD-856 for cognition
Other compounds: I am currently on 2.5mg of retatrutide every 5 days (will move up to 5 soon), 25mg of exemestane every day, and I will be starting telmisartan soon.

I have seen nothing but kindness on this forum and I am very grateful, this is my first "real" post

 

[Psy-chonaut]

If you want to educate yourself in what peoples practice/protocols are (higher dosing), anecdotes, side effects etc...

This is a rather good thread about the subject:

Thread 'Accutane permanent cure?'

May 3, 2024

I've read one or two 6 month courses of Accutane can permanently cure acne in a lot of cases.

Has this worked permanently for anyone with steroid induced acne?

I suspect a permanent cure isn't for the steroid induced type, but I'd like to know if it's worth a try given the nasty sides or just stick to Doxycycline, which is effective and no sides but temporary.

• Ghoul

• 

 

[synthetic_juggernaut]

"100mg melatonin nightly" "25mg of exemestane every day"; the accutane protocol looks reasonable, but these 2 jump out. Why so high?

 

[BigDadd7]

"100mg melatonin nightly" "25mg of exemestane every day"; the accutane protocol looks reasonable, but these 2 jump out. Why so high?

Say goodbye to e2 instantly

 

[BendigoShafter]

What is your weight and why are you shooting for 10,000mg cumulative?

 

[IndividualMan]

What is your weight and why are you shooting for 10,000mg cumulative?

10k cumulative dose is the point where you get pretty permanent changes with accutane. 20k is probably better if the acne is real bad,

nothing but kindness on this forum

seems you have not read enough

Btw, the 25mg exemestane are very high, usually people on 2-3g of test dont take that much. get a high sensitive E2 test with your bloodwork, crazy low E2 might be a reason why your skin is crap.

100mg melatonin is also pretty high, but if you dont feel groggy/sleepy all day its alright.

Tudca you can run anywhere from 250mg/day to 3-4g, as much as your digestion allows really. overdoing it just burns money, so only up the dose if you think it is needed.

also: stats? height, weight, lifting experience, age, etc.?

 

[BendigoShafter]

10k cumulative dose is the point where you get pretty permanent changes with accutane. 20k is probably better if the acne is real bad,

Yeah that's why I asked about his weight. 10,000mg is a conveniently round number.

From my notes, usually cumulative dose for facial acne is 120 to 150 mg/kg of body weight. For body acne, cumulative target is 220 mg/kg.