Repurposed drugs

Yeah copy. I had my medications about 1.5 hours earlier than normal yesterday and had a stellar sleep. I think timing helps a lot with these medications.

I thought mirabegron was to stop you waking to go for a piss?
Exactly, stops you from going to pee thus helps me massively to sleep through cause i pee like a horse normally, not every 20-30 minutes but just drink a lot and with a SGTL2 in play you will just urinate more frequently in general
 
Exactly, stops you from going to pee thus helps me massively to sleep through cause i pee like a horse normally, not every 20-30 minutes but just drink a lot and with a SGTL2 in play you will just urinate more frequently in general
You know that continuously peeing could mean your kidneys are not shutting off because you're not hitting the proper sleep stages. I had that issue before I started CPAP machine.

Might be unrelated....
 
You know that continuously peeing could mean your kidneys are not shutting off because you're not hitting the proper sleep stages. I had that issue before I started CPAP machine.

Might be unrelated....
Yep good point but they are fine, i just pee a lot and have a small bladder unfortunately. Prostate is also good togo
 
Interesting. I found taking Mirtazapine seems to make my semaglutide less effective. It seems to work for gastroporesis:


Maybe having some on hand in case of a GLP1 overdose is a good idea?
I've only ever been on tirzepatide while on mirtazapine, but it works just fine for me on a low dose of tirzepatide. That's interesting that you've noticed a difference. Is it quite a marked one?
 
I've only ever been on tirzepatide while on mirtazapine, but it works just fine for me on a low dose of tirzepatide. That's interesting that you've noticed a difference. Is it quite a marked one?
Yes. Hunger is still there and the stomach doesn't get totally stopped.

But it's still early days. I'll leave a comment when I spend a month at 3mg per week (previous highest dose of sema).

I think it would probably counter the effects of GLP1 more than GIP. But that's just me bro sciencing. Be good if other people give it a whirl.
 

View: https://youtu.be/2Nydy3PeRdE


It seems MAOI's can be used to lower blood pressure. I wonder if it has any benefit for bodybuilders who have mood disorders/hypertension AND high blood pressure.

I am looking into these two compounds:
Phenelzine
Tranylcypromine

There are less sexual dysfunction with this class of drugs which is relevant to me because I still get some sexual dysfunction on sertraline. Mirtazapine helps but any dose of sertraline north of 50mg is touch and go.

The atypical antidepressants or antidepressants that have less sexual side effects usually don't work too well in more severe cases of depression.
 

View: https://youtu.be/2Nydy3PeRdE


It seems MAOI's can be used to lower blood pressure. I wonder if it has any benefit for bodybuilders who have mood disorders/hypertension AND high blood pressure.

I am looking into these two compounds:
Phenelzine
Tranylcypromine

There are less sexual dysfunction with this class of drugs which is relevant to me because I still get some sexual dysfunction on sertraline. Mirtazapine helps but any dose of sertraline north of 50mg is touch and go.

The atypical antidepressants or antidepressants that have less sexual side effects usually don't work too well in more severe cases of depression.

Caveat: I have not personally used these drugs, but I have researched them extensively.

Phenelzine is notorious for causing sexual dysfunction, if you search through user experience reports on forums, Reddit, etc. Of course, the people who don't experience SD don't complain about it on the internet, but it is reported significantly more than tranylcypromine.

Tranylcypromine seems more like a mixed bag, like any other antidepressant.

Talking of hypertension, you need to be aware of the risk of hypertensive crisis if you consume tyramine rich foods, such as cured meats and aged cheese. So you have to be aware of your diet. A workaround to this is to take nortriptyline, which eliminates the risk, according to Dr Gillman.

Also, you absolutely cannot take sertraline or any other SSRI while on an MAOI, or it will cause potentially fatal serotonin toxicity.

If you want to know more, Kenny G is the world leading expert on them. He knows what he is talking about and debunks many myths and untruths about them on his website

 
Caveat: I have not personally used these drugs, but I have researched them extensively.

Phenelzine is notorious for causing sexual dysfunction, if you search through user experience reports on forums, Reddit, etc. Of course, the people who don't experience SD don't complain about it on the internet, but it is reported significantly more than tranylcypromine.

Tranylcypromine seems more like a mixed bag, like any other antidepressant.

Talking of hypertension, you need to be aware of the risk of hypertensive crisis if you consume tyramine rich foods, such as cured meats and aged cheese. So you have to be aware of your diet. A workaround to this is to take nortriptyline, which eliminates the risk, according to Dr Gillman.

Also, you absolutely cannot take sertraline or any other SSRI while on an MAOI, or it will cause potentially fatal serotonin toxicity.

If you want to know more, Kenny G is the world leading expert on them. He knows what he is talking about and debunks many myths and untruths about them on his website

Yeah copy. Guess I'll give Vortioxetine a spin first then. Thanks for the info bro.

That bloke gives some great info on dopamine. Seems like the discussion around depression isn't complete without it. Anti depressants are actually anti anxiety meds due to the dopamine issue.
 
There's also Cimetidine the old heart burn medication, it can remove stubborn warts and reduce the pain of shingles.

And Sumatriptan, the migraine drug, for sexual function. In some people it causes spontaneous ejaculation though, you may want to skip it during family gatherings.
 
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