Should you take lower dosages of SS-31 over a longer period of time or high doages for a short time?

[Proud Pangolin]

Well the question is basiacally in the titel.
Obviously high dosages for a longer period of time would be best. However as 10x50mg (=500mg) cost me like 330 bucks..... yeah you get the idea.

I could do 10mg for 50 days, 30mg for 16 days or 40mg for 12 days.

https://www.reddit.com/r/cfs/s/NRGClDtqS5

This guys claims that the high dosages of 30mg hat a permanent improving effect and 40mg is the dosage that is used in all the studys.

To complicate things further, that guy from reddit didnt took the 30mg every day but: "each time I started to feel normal again, I took another dose, until I had done 10 of these 30mg dosages."

So basically im left with 3 possible protocolls:
1.Low dose every day for a long time

2. high dose every couple of days (so instead of 10mg every day, i could take 30mg every 3 days)

3. high dosage every day for a short time.

There are arguments for both sides.
One may argue that people take SS-31 for a to short time and they have to take it for at at least 4 weeks

Others would argue, a high enough dosage is needed to pass a certain "threshold"


Has anyone tried SS-31 and/ or could share his opinion about this?

 

[Nidus]

I personally always loved longer duration at moderate doses -> 15mg for 3 Months and had an amazing experience overall. I do combine with with a bunch of other Mito supps and peps like Motsc though.

 

[nxckf]

Tried both. Didn’t notice anything tbh. Tried to make my $330 kit stretch. Then tried again pushing higher doses (30-40mg a day). Ran mots C after- might as well just inject BAC water. Maybe my mitochondria are just functioning fine but I noticed no benefit

 

[SmallTitsIRL]

Unless you have kidney/heart disease or any order disorder that you need SS31 to survive/recover, there's no reason to do 40-50mg daily, you'd be better off doing 1-5mg daily pre-workout/cardio with 1-5mg MotsC for the energy, fat metabolism and blood glucose benefits.

 

[level3]

Anecdotally I feel like most people who rave about SS-31 are older - especially people 50+. Or they have some serious medical condition, like the guy in your post. I tried it at 4mg/day for a month last year and didn't notice jack shit, but I'm in my mid 30's and probably didn't need it. Then I saw how all the scientific studies used doses like 10x that. Too expensive for me. Decided to bin it and maybe give it another shot in my 40's once I have many years worth of every other peptide I like in stock and dropping a grand on a mitochondria experiment feels worthwhile.

 

[Proud Pangolin]

Tried both. Didn’t notice anything tbh. Tried to make my $330 kit stretch. Then tried again pushing higher doses (30-40mg a day). Ran mots C after- might as well just inject BAC water. Maybe my mitochondria are just functioning fine but I noticed no benefit

so you didnt even notice something on higher dosages per day? Interesting

 

[BeardedGuy]

SS-31 5mg/day just made me tired. ‍

 

[touringsedan]

40mg/day was the only dose used on humans. If it worked lower, it would have been used lower.
Trials were 6 months and daily dosing was required to maintain effects, so it doesn't have permanent/repair mechanisms. You need to stay on the drug to keep improvements.

 

[Here2Learn]

The Mayo Clinic is running a private trial, read lots of posts from a guy in it, and they are working towards 100mg/day for a year. It is a study focused on those over 40 and their biomarkers. He said the binaries improvements have been impressive for everyone enrolled. It is not a blind study but sounds more like a you have enough money you donated to us we are going to invite you in kind of thing. Last I knew they were up to 60mg/day. I’ve titrated up to 20mg/day at this point, got there January 4th so almost a month. My first run I was exhausted all the time and had to tap out at 16mg/day. From what I understand, those over 40 ss-31 is the way to go and those under mots-c is the way to go. I am sure there are outliers but a general rule of thumb.

 

[SwampNut]

SS-31 5mg/day just made me tired. ‍

Same here, a few hours later and I'm beat. Have to nap. I am considering doing it late just before bed, wonder what it will do for sleep. I've also considered higher doses since all the studies have been higher.

 

[Here2Learn]

Same here, a few hours later and I'm beat. Have to nap. I am considering doing it late just before bed, wonder what it will do for sleep. I've also considered higher doses since all the studies have been higher.

Likely you need a methyl donor like TMG, I had to add it the first time to combat the fatigue.

 

[Mr.AAJR]

40 mg was used in the trials because it is used to treat Barth Syndrome, which is a form of SEVERE mitochondrial dysfunction. Not because lower doses don't work. If you do not have Barth, you almost certainly will see no added benefit from going up to 40 mg.

 

[SwampNut]

Likely you need a methyl donor like TMG, I had to add it the first time to combat the fatigue.

I did combine it with TMG, either 750 or 1500 mg, prior to use, the same day, used daily while using SS-31.

 

[Proud Pangolin]

I did combine it with TMG, either 750 or 1500 mg, prior to use, the same day, used daily while using SS-31.

going to add some TMG. I may also combine it wie with SLU-PP

 

[Proud Pangolin]

I personally always loved longer duration at moderate doses -> 15mg for 3 Months and had an amazing experience overall. I do combine with with a bunch of other Mito supps and peps like Motsc though.

die you combine it with SLU-PP ? If so, what was you dosing?

 

[Proud Pangolin]

Same here, a few hours later and I'm beat. Have to nap. I am considering doing it late just before bed, wonder what it will do for sleep. I've also considered higher doses since all the studies have been higher.

its really weird that so many people get.tired from it. And at other dosages the exact opposite happens. Its nit only the guy i talked about, this seem to be pretty common. Did this eventually went away?

 

[Cita]

SS-31 5mg/day just made me tired. ‍

Me too. The higher the doseage, the more fatigue experienced.