They offer a copay card: NEXLETOLâ„¢ (bempedoic acid) Co-Pay Card Website
MESO-Rx
Anabolic Steroids
Pitavastatin+Bempedoic acid+Ezetimbe really works well.
- Thread starter Raww
- Start date
RockyP
Member
Yes sir - just used it earlier today!
I have a stupid question, maybe @Ghoul can chime in.
One of the criticisms I hear, but do not agree with, is that simply chasing LDL numbers is not helpful, and that outcomes data is where it's at. Now I think that's true and not true, and way too nuanced to dive into. But my question is this...
If we have 3 distinct classes of drugs (statins, zetia, Nexletol) that all lower LDL independently, and all have positive outcomes data associated with them, is there any way that using them altogether would not have a synergistic impact on outcomes? Meaning that is there any manner in which combining pitavastatin, Zetia, and Nexletol, which we know will lower LDL significantly in combination, somehow does not lead to better outcomes data than just using one, or two of them alone?
I'm also still hearing some ( a lot ) of pushback from docs of various specialties regarding the "don't drop your LDL too low" mantra of yesteryear. I know this paper is only 18 months old, but it is a potential paradigm shift in how lipids are managed, and not a single doc I've spoken with was 1) aware of it, and 2) thought it was compelling.
@Ghoul is there ANY reason to "not let your LDL go too low"?
Photon
Member
Works for Nexlizet too.
Bemp + Eze combo.
$25/90d.
Quite easy to get a 1 year rx from a doc.
Most IndiaMart vendors don't reship, but given how much you save vs the other vendors here, you can easily afford a few seizures. They use the same shipping routes.
Id send u a message but u never respond… like the last couple messages i sentcha
Ghoul
Member
50%, but the prices are so low, as long as you aren’t extremely unlucky you should more than make up for any seizures.
(Knock on wood) 9 packs all got through no issue.
Photon
Member
yeah, I just checked the prices. Got my answer.
just some dude
Member
surprised repatha hasn’t “leaked” onto the supply chain yet -
very high IQ lipid stack - congrats on the results!
just some dude
Member
was it really that bad? i haven’t heard back
got all the oral stuff but i wanna have that for when i wanna run androgens again. powerful.
deuces_00
New Member
good read. thanks for the article.
Ghoul
Member
Yes sir - just used it earlier today!
I have a stupid question, maybe @Ghoul can chime in.
One of the criticisms I hear, but do not agree with, is that simply chasing LDL numbers is not helpful, and that outcomes data is where it's at. Now I think that's true and not true, and way too nuanced to dive into. But my question is this...
If we have 3 distinct classes of drugs (statins, zetia, Nexletol) that all lower LDL independently, and all have positive outcomes data associated with them, is there any way that using them altogether would not have a synergistic impact on outcomes? Meaning that is there any manner in which combining pitavastatin, Zetia, and Nexletol, which we know will lower LDL significantly in combination, somehow does not lead to better outcomes data than just using one, or two of them alone?
I'm also still hearing some ( a lot ) of pushback from docs of various specialties regarding the "don't drop your LDL too low" mantra of yesteryear. I know this paper is only 18 months old, but it is a potential paradigm shift in how lipids are managed, and not a single doc I've spoken with was 1) aware of it, and 2) thought it was compelling.
@Ghoul is there ANY reason to "not let your LDL go too low"?
No. Thanks to the original Repatha trials being extended indefinitely, we know there aren’t any “signals” of negative effects years after achieving ultra low LDL (down to single digits). The only new evidence is increasingly reduced risk of cardiovascular events (ie heart attack or stroke) with each passing year, presumably because the old plaque keeps getting more stable as it’s deprived of fresh cholesterol for longer, keeps drying out, getting more and more calcified.
They all three work synergistically together.
This clinical trial found the combination of Eze & BA to have the most favorable outcomes compared to any other oral monotherapy paired with a statin.
Ghoul
Member
And to build on this, because I think one of the incredible impacts of the massive amount of research that’s gone into cardiovascular disease in recent decades, is that things have become SIMPLER and CLEARER, rather than more complex.
In this case, regardless of how LDL is lowered, CVD risk drops. Results have been very consistent across hundreds of studies.. When LDL is reduced by X, risk goes down by X.
So simply, if 1, 2, or 3, or 4 drugs are used, if each contributes to lowering LDL, risk is reduced.
Its so weird because why would repatha sign an agreement stating they would refund insurance if anyone has a heart attack or stroke while using it…
So it makes me wonder what numbers should look like if their numbers were over the 130 they surmised?
“patients who started with LDL levels around 130 mg/dL, and saw a drop in CVD events of about 22% for every 39 mg/dL drop in
LDL. In this study,”
Im with u tho the tendon ruptureing thing scares me but also statins and i dont mix well… had a clot on 5 mlg of crestor…
Ghoul
Member
That’s just a representative example of the typical subject in the large scale studies the data came from.
From 70 to 180 mg/dL the proportional reduction in major cardiovascular events is about 21–22% for each ~39 mg/dL decrease in LDL-C.
