Clen , beta 1 selective beta blockers, and ANP

[Gonz0]

I recently started using clenbuterol, I’m already on nebivolol for blood pressure and since it’s a highly selective beta blocker it should just decrease the side effects from clen while still allowing it to work , unlike if you were to use a non selective beta blocker. Lyle McDonald has a book called the “stubborn fat loss solution patch 1.1” where he goes over the synergy of using a highly selective beta blocker to make your heart release ANP and combining it with clenbuterol for enhanced fat loss. I personally have had great results with this combination, I’m pretty sensitive to stimulants and even at 120mcg of clen daily all I feel is a little extra energy and just a liiiiiitle shaky sometimes but nothing crazy. I’m just wondering if outside of helping with the side effects, does it really enhance fat loss compared to just running clen on its own ?

 

[BP_6]

If you heart is a concern and you really must use a B-2 agonist, may I suggest salbutamol "albuterol" oral. It is more B-2 specific than even clenbuterol and has less sides in almost all areas including the heart. It isn't quite as effective though. It's half life is also much shorter so at least 2x a day is usually used. It is also literally about the cheapest pharm grade compound I have come across.

 

[Gonz0]

If you heart is a concern and you really must use a B-2 agonist, may I suggest salbutamol "albuterol" oral. It is more B-2 specific than even clenbuterol and has less sides in almost all areas including the heart. It isn't quite as effective though. It's half life is also much shorter so at least 2x a day is usually used. It is also literally about the cheapest pharm grade compound I have come across.

That’s good to know man , I’m gonna try that out in the future, I liked ephedrine in the past because it wouldn’t last long so I could hit my fasted cardio and just get on with my day, definitely looking forward to giving the salbutamol tabs a shot.

 

[BeardedGuy]

If you heart is a concern and you really must use a B-2 agonist, may I suggest salbutamol "albuterol" oral. It is more B-2 specific than even clenbuterol and has less sides in almost all areas including the heart. It isn't quite as effective though. It's half life is also much shorter so at least 2x a day is usually used. It is also literally about the cheapest pharm grade compound I have come across.

So Sal and Clen burns fat in a controlled way which you can let wear off pretty quickly if you aren’t feeling it?

 

[Gonz0]

So Sal and Clen burns fat in a controlled way which you can let wear off pretty quickly if you aren’t feeling it?

Salbutamol has a very fast half life, like 5 hours or something, clen has a 36 hour half life. I’ve been using nebivolol to counter any side effects caused by the clen and so far it’s been working. Interested in trying salbutamol in future cuts

 

[Deadpool99]

I recently started using clenbuterol, I’m already on nebivolol for blood pressure and since it’s a highly selective beta blocker it should just decrease the side effects from clen while still allowing it to work , unlike if you were to use a non selective beta blocker. Lyle McDonald has a book called the “stubborn fat loss solution patch 1.1” where he goes over the synergy of using a highly selective beta blocker to make your heart release ANP and combining it with clenbuterol for enhanced fat loss. I personally have had great results with this combination, I’m pretty sensitive to stimulants and even at 120mcg of clen daily all I feel is a little extra energy and just a liiiiiitle shaky sometimes but nothing crazy. I’m just wondering if outside of helping with the side effects, does it really enhance fat loss compared to just running clen on its own ?

I had this exact thought process, I also mentioned this previously, Ghoul also verified my suspicions.

It'll almost neutralize Clen's effect, and reduce it slightly from T3.

However, I found an alternative I kept on hand. Ivabradine

To my knowledge,
Nebivolol can definitely help with clenbuterol’s side effects like high heart rate and blood pressure, but it also dulls part of what makes clen work. Even though it’s a highly selective b1-blocker, it still reduces overall sympathetic output and lowers your heart’s workload, which in turn cuts into the thermogenic and total daily energy expenditure boost clen normally gives. You’ll still burn fat, but not quite as efficiently, nebivolol trades a bit of clen’s metabolic drive for cardiovascular safety and smoother tolerability.
As I care alot about clen's TDEE boost.

Ivabradine, on the other hand, seems a better match for this purpose. Instead of blocking any b-receptors, it slows your heart by targeting the “funny current” in the sinoatrial node, leaving b2-receptor activity (and thus clen’s fat-burning pathway) untouched.

In theory, that means you can keep the thermogenic benefits of clenbuterol while keeping your heart rate under control. On paper it's way cleaner pharmacologically.

 

[dcfreak]

Pretty sensitive to stimulants and my man is on 120mcg clen lol.

Right there with ya brother. Glad you started the thread. The Nebivolol, unfortunately, does not seem to be reducing my heart rate much- but with the reta, occasional ECY, clen I am still in the 90s usually.

Ive heard some people dont respond to Nebivolol?

 

[Deadpool99]

Pretty sensitive to stimulants and my man is on 120mcg clen lol.

Right there with ya brother. Glad you started the thread. The Nebivolol, unfortunately, does not seem to be reducing my heart rate much- but with the reta, occasional ECY, clen I am still in the 90s usually.

Ive heard some people dont respond to Nebivolol?

I personally fuck around with Clen and don’t mind it if my RHR is 95 or below, I just keep it as is.

It’t the only side effects I get and I get 0 chest pain or anxiety or insomnia so if that’s the worst side effects, it’s probably gonna be short term and idm it.

It usually drops down in a few days, atleast when I use it.

 

[Gonz0]

I had this exact thought process, I also mentioned this previously, Ghoul also verified my suspicions.


However, I found an alternative I kept on hand. Ivabradine

To my knowledge,
Nebivolol can definitely help with clenbuterol’s side effects like high heart rate and blood pressure, but it also dulls part of what makes clen work. Even though it’s a highly selective b1-blocker, it still reduces overall sympathetic output and lowers your heart’s workload, which in turn cuts into the thermogenic and total daily energy expenditure boost clen normally gives. You’ll still burn fat, but not quite as efficiently, nebivolol trades a bit of clen’s metabolic drive for cardiovascular safety and smoother tolerability.
As I care alot about clen's TDEE boost.

Ivabradine, on the other hand, seems a better match for this purpose. Instead of blocking any b-receptors, it slows your heart by targeting the “funny current” in the sinoatrial node, leaving b2-receptor activity (and thus clen’s fat-burning pathway) untouched.

In theory, that means you can keep the thermogenic benefits of clenbuterol while keeping your heart rate under control. On paper it's way cleaner pharmacologically.

Thanks for the reply brother ! I’ll definitely have to look into ivabradine, this is my first time using clen so I have no baseline of what it feels like without the nebivilol. Do you think since nebivolol causes the heart to release ANP and that in turn is mobilizing more fat cells that it kind of makes up for any loss of metabolic drive that the nebivilol would be causing ? I’ve never seen anyone except Lyle talk about the connection between ANP, selective beta blockers, and clen, after looking into ivabradine I’ll definitely be giving it a go on my next run with clen and compare results.

 

[Gonz0]

Pretty sensitive to stimulants and my man is on 120mcg clen lol.

Right there with ya brother. Glad you started the thread. The Nebivolol, unfortunately, does not seem to be reducing my heart rate much- but with the reta, occasional ECY, clen I am still in the 90s usually.

Ive heard some people dont respond to Nebivolol?

Lmaooo dude the nebivilol worked almost too good and had me thinking my clen was bunk , jumped to 120 pretty quick and have just kind of stuck there. That’s weird you’re not getting any results from the nebivilol, how much are you taking? I usually run 5mg but I’ve bumped it up to 10mg daily while on the clen and that’s been working much better

 

[dcfreak]

Lmaooo dude the nebivilol worked almost too good and had me thinking my clen was bunk , jumped to 120 pretty quick and have just kind of stuck there. That’s weird you’re not getting any results from the nebivilol, how much are you taking? I usually run 5mg but I’ve bumped it up to 10mg daily while on the clen and that’s been working much better

Yeah I think that might be the move. That doctor gave me the propranolol but that for sure will reduce the clen effects so ive been running the 5mg Nebivolol but yeah Im still at like 98 this morning sheeeesh.

Could be the 200mg a day SLU-PP-322 as well

 

[Deadpool99]

Thanks for the reply brother ! I’ll definitely have to look into ivabradine, this is my first time using clen so I have no baseline of what it feels like without the nebivilol. Do you think since nebivolol causes the heart to release ANP and that in turn is mobilizing more fat cells that it kind of makes up for any loss of metabolic drive that the nebivilol would be causing ? I’ve never seen anyone except Lyle talk about the connection between ANP, selective beta blockers, and clen, after looking into ivabradine I’ll definitely be giving it a go on my next run with clen and compare results.

That ANP mechanism is interesting but still mostly theoretical. Nebivolol can increase ANP release a bit, and ANP does promote lipolysis, so it might partially counteract the reduced thermogenesis and TDEE that come from beta-blockade, but not enough to fully replace what you lose by blunting sympathetic output.

But I am quite skeptical on the ANP effect, sounds weak and haven’t seen anyone who has proven to create measurable extra fat loss in humans (both anecdotal and on paper).

So while nebivolol may keep clen more tolerable, it probably doesn’t enhance total fat-loss efficiency versus clen alone.

Ivabradine in my eyes remains the cleaner option for your next run

 

[Gonz0]

That ANP mechanism is interesting but still mostly theoretical. Nebivolol can increase ANP release a bit, and ANP does promote lipolysis, so it might partially counteract the reduced thermogenesis and TDEE that come from beta-blockade, but not enough to fully replace what you lose by blunting sympathetic output.

But I am quite skeptical on the ANP effect, sounds weak and haven’t seen anyone who has proven to create measurable extra fat loss in humans (both anecdotal and on paper).

So while nebivolol may keep clen more tolerable, it probably doesn’t enhance total fat-loss efficiency versus clen alone.

Ivabradine in my eyes remains the cleaner option for your next run

Yeah it sounds good on paper but the lack of evidence/human studies leaves a lot up in the air. It would definitely be nice if it worked that way lol, I’ll be grabbing some iverbradine for my next clen run and compare results, appreciate the feedback man !

 

[Deadpool99]

Yeah it sounds good on paper but the lack of evidence/human studies leaves a lot up in the air. It would definitely be nice if it worked that way lol, I’ll be grabbing some iverbradine for my next clen run and compare results, appreciate the feedback man !

Np, anytime

 

[Gonz0]

Yeah I think that might be the move. That doctor gave me the propranolol but that for sure will reduce the clen effects so ive been running the 5mg Nebivolol but yeah Im still at like 98 this morning sheeeesh.

Could be the 200mg a day SLU-PP-322 as well

You have inspired me to get those slu numbers up , once wwb drops those 100mg tabs it’s gonna be over !

 

[dcfreak]

You have inspired me to get those slu numbers up , once wwb drops those 100mg tabs it’s gonna be over !

Lets do this