HGH + Retatrutide

[Ateam2023]

How long did you take it for before you stopped?

I had the same effect at 1mg a week. But after about 1.5 months and dosing 4mg week, my appetite is back. No issues eating , just cant eat as much before my brain tells me to stop.

@6 weeks or so ,

 

[deadbeef]

I looked at the phase 2 trial data, and .5mg of Reta per week had a pretty significant effect on glucose lowering. If that’s all you can handle, it’s still with the effort, but higher is better.

No statistical significance when compared to placebo so, no, there is no data that shows that.

 

[Ateam2023]

Well i can say before i was on reta for that short while , my fbg was creeping up into the 95+ range but @.5 mg Reta split into two doses M/Thur , i started seeing my fbg into the 85 so i will say that i did get something out of a small dose, everyone responds differently to this shit so to flat out say "because phase 2 says this" is BS , Real world applications is what i go off , these "starting doses" are a suggestion , they want you using more mg per dose so the pharmaceutical companies can make more money .

 

[Ateam2023]

My abs sure starting popping when i was on reta, i finally saw some "Ab veins" in my shit!, yeahhhhh boiiii!,

 

[Turkeybuilder]

Muscle memory is my saving grace, after being on righteous Trt for around 6 months and two torn rotator cuffs, its really been a humbling experience to "work around" these injuries and lower doses of everything, no sense in using more than a trt dose if I can't train like i want too. And my first shoulder surgery being "delayed" because of an irregular EKG has set everything back, i go see the cardiologist tomorrow to see whats going on. HUMBLING is all i can say

wishing you well at the cardiologist. Curious what your EKG showed, I can also explain results if you shoot them to my DM.

 

[Ateam2023]

wishing you well at the cardiologist. Curious what your EKG showed, I can also explain results if you shoot them to my DM.

I didnt get them , i will try to see if i can get them from my dr. Thanks Brother

 

[Ateam2023]

wishing you well at the cardiologist. Curious what your EKG showed, I can also explain results if you shoot them to my DM.

My dr is asking the cardiologist in his notes "if this was a Premature atrial contraction", so thats what he thinks, like a normal rythem then a double beat.

 

[deadbeef]

Well i can say before i was on reta for that short while , my fbg was creeping up into the 95+ range but @.5 mg Reta split into two doses M/Thur , i started seeing my fbg into the 85 so i will say that i did get something out of a small dose, everyone responds differently to this shit so to flat out say "because phase 2 says this" is BS , Real world applications is what i go off , these "starting doses" are a suggestion , they want you using more mg per dose so the pharmaceutical companies can make more money .

The placebo group in the phase 2 lowered their glucose more than that.

 

[Turkeybuilder]

My dr is asking the cardiologist in his notes "if this was a Premature atrial contraction", so thats what he thinks, like a normal rythem then a double beat.

oh well that's good news. You made it seem like it was something real bad. PAC's are very normal, anything can cause those between stress, anxiety, electrolyte imbalances, poor sleep, too much caffeine intake. Very surprised the presence of a PAC is off-setting your surgery, are you sure that's all it is?

 

[Ateam2023]

oh well that's good news. You made it seem like it was something real bad. PAC's are very normal, anything can cause those between stress, anxiety, electrolyte imbalances, poor sleep, too much caffeine intake. Very surprised the presence of a PAC is off-setting your surgery, are you sure that's all it is?

My pcp said he wouldn't clear me for shoulder surgery because of that , he plays it safe i guess which is good i guess , its just i was due for surgery on November 7 , now who knows , if i can get cleared tomarrow then i have a good chance of making that date, I never been in such a rush to get a surgery, but these shoulders are bad, both shoulders have mirror image full thickness tears of the infraspinatus and supraspinatus, stemming from a car accident in 2022, i didnt know they were torn for 3 years until i just couldn't stand the pain and the decrease in strength was baffling me, here i am pounding away in the gym slinging 35 lb dumbells doing side laterals etc , but each month my weight was decreasing instead of increasing, Mri confirmed the reasons, This right shoulder is considered a massive tear because its a "re-tear" from 2018 its retracted like 4.5 cm , they are doing a biological mesh implant on that one

 

[Turkeybuilder]

That sounds awful man i'm sorry to hear. hopefully your recovery goes well and things go back into order afterwards. glad you found the cause of all the pain

My pcp said he wouldn't clear me for shoulder surgery because of that , he plays it safe i guess which is good i guess , its just i was due for surgery on November 7 , now who knows , if i can get cleared tomarrow then i have a good chance of making that date, I never been in such a rush to get a surgery, but these shoulders are bad, both shoulders have mirror image full thickness tears of the infraspinatus and supraspinatus, stemming from a car accident in 2022, i didnt know they were torn for 3 years until i just couldn't stand the pain and the decrease in strength was baffling me, here i am pounding away in the gym slinging 35 lb dumbells doing side laterals etc , but each month my weight was decreasing instead of increasing, Mri confirmed the reasons, This right shoulder is considered a massive tear because its a "re-tear" from 2018 its retracted like 4.5 cm , they are doing a biological mesh implant on that one

 

[Endeavor Fitness]

Delaying GH conversion to IGF as much as possible. IGF conversion is accelerated by insulin release, ie, eating (esp carbs). A fasted state will maintain max circulating GH as long as possible, which is roughly 3-4 hours post injection.

GH is responsible for enhanced fat lipolysis (signals fat cells to release free fatty acids and conditions muscles to use them for energy). Visible anti-aging effects, particularly skin quality, are a function of GH, not IGF.

If you have weight to lose, and/or you're susceptible to diabetes (get an A1C blood test before starting, as well as baseline IGF, both cheap tests), Tirz will work better than Reta. Its insulin sensitivity improving (ie, anti-diabetic) effects are superior to Reta. Reta will dump even more glucose into your blood, potentially worsening the situation if you're borderline pre-diabetic.

This is completely factual. I started with Tirz, then went to reta. I added "Jardiance" 5-10 mg at night to combat the glucose issue.

I take my Reta 1 mg/ 2 doses/wk in the morning. Add Injectable L-Carnitine pre-workout. Then at night, when I wake up around 2 am, I shoot my GH 2 ius (4 days/week) with 5-10 mg of Jardiance.

 

[Ghoul]

This is completely factual. I started with Tirz, then went to reta. I added "Jardiance" 5-10 mg at night to combat the glucose issue.

I take my Reta 1 mg/ 2 doses/wk in the morning. Add Injectable L-Carnitine pre-workout. Then at night, when I wake up around 2 am, I shoot my GH 2 ius (4 days/week) with 5-10 mg of Jardiance.

Jardiance also prevents scarring in heart tissue (fibrosis), which glucagon promotes, so another good reason to pair with Reta. A lot of people use Jardiance to prevent progressive (age related) decline of the heart and kidneys, which it’s proved very effective at.

 

[Endeavor Fitness]

Yeah, my Doc was telling me how more cardio docs are using it with their patients. He asked me if I wanted to try, just to offset. I said it couldn't hurt. So far, it's working.

 

[Lifting88]

Jardiance also prevents scarring in heart tissue (fibrosis), which glucagon promotes, so another good reason to pair with Reta. A lot of people use Jardiance to prevent progressive (age related) decline of the heart and kidneys, which it’s proved very effective at.

Sounds good bad is quit expensive

 

[dudemos]

I’m currently on a TRT dose of 150mg per week, and 1.5mg of reta per week.

I’ve got HGH and looking to start at a conservative dose of 2iu daily and titrate slowly to 4iu.

What time of the day AM vs PM would be most ideal? And with the positive effect of insulin sensitivity from using the reta, is there more of an argument that timing of the day is less important (provided that I take HGH fasted or 2-3 hours after my last meal)?

Interesting stack, I've read that HGH is best taken fasted to maximize its effects, especially for fat loss. Considering reta's impact on insulin, AM might be better to delay the GH to IGF conversion.

 

[deadbeef]

Tirz will work better than Reta. Its insulin sensitivity improving (ie, anti-diabetic) effects are superior to Reta.

The insulin sensitivity markers show reta is far superior for insulin sensitivity than tirz. Are you confusing glucose control with insulin sensitivity?

Marker	Reta	Tirz
Fasting Glucose	-32 mg/dL	-48.8 mg/dL
HbA1c	-2.0%	-2.46%
Fasting Insulin	-41.6%	-20.9%
HOMA2-IR	-38.9%	-24.0%
Adiponectin	+53%	+23%

It's even better for reta if you look at the numbers from the MASLD study.

 

[masternak]

how much individual variation there is with Reta's appetite suppression. I guess it just goes to show how different we all are.

 

[Ghoul]

The insulin sensitivity markers show reta is far superior for insulin sensitivity than tirz. Are you confusing glucose control with insulin sensitivity?

Marker	Reta	Tirz
Fasting Glucose	-32 mg/dL	-48.8 mg/dL
HbA1c	-2.0%	-2.46%
Fasting Insulin	-41.6%	-20.9%
HOMA2-IR	-38.9%	-24.0%
Adiponectin	+53%	+23%

It's even better for reta if you look at the numbers from the MASLD study.

What’s the source of that data? Without dose and duration it doesn’t tell us anything, and it doesn’t explain away the mechanistic action of glucagon making the liver dump glucose into blood, The same glucagon process that clears liver fat more quickly by oxidizing that fat as it produces sugar, makes it worse at insulin sensitivity which is fundamentally a function of insulin exposure time. Carrying the extra blood sugar around that Reta causes via glucagon means more insulin exposure, making Rets inferior to Tirz at maintaining lower fasting glucose and insulin sensitivity.

Said another way:

Reta causes constant glucagon signal → liver releases glucose → blood glucose rises → pancreas secretes more insulin to compensate = higher insulin exposure.

Tirz, by contrast, lowers glucose via GLP-1 and GIP effects without raising glucagon, so less compensatory insulin is needed = lower insulin exposure.

 

[beorn777]

What’s the source of that data? Without dose and duration it doesn’t tell us anything, and it doesn’t explain away the mechanistic action of glucagon making the liver dump glucose into blood, The same glucagon process that clears liver fat more quickly, turning liver fat into sugar, makes it worse at insulin sensitivity which is fundamentally a function of insulin exposure time. Carrying the extra blood sugar around that Reta causes via glucagon means more insulin exposure, making Rets inferior to Tirz at maintaining lower fasting glucose and insulin sensitivity.

Said another way:

Reta causes constant glucagon signal → liver releases glucose → blood glucose rises → pancreas secretes more insulin to compensate = higher insulin exposure.

Tirz, by contrast, lowers glucose via GLP-1 and GIP effects without raising glucagon, so less compensatory insulin is needed = lower insulin exposure.

How would this change if you used insulin daily or used a reta dose that doesn't effect the glucagon receptor? I've been using 4mg reta with gh and slin pre / post wo and I'm staying leaner than I had without reta but maybe my glucagon isn't that high I haven't had bloods yet.