hGH Experimental LOG - Skyhigh Doses

koast123

Member
Hi everyone!

I’ve got the chance to finally do something I’ve always wanted — really push the limits with growth hormone and see what happens at very high doses. I’ve been into this for a long time, over 15 years of training and around 10 competing, so I’d consider myself an advanced user when it comes to PEDs.

Up to now, I’ve never gone past what you’d call moderate GH amounts (8-10iu), but I might soon have access to a setup that allows me to try a much higher protocol (18-27iu a day) — purely out of curiosity and to see how much truth there is in the idea that “the higher you go, the better the results.”

I wanted to hear your thoughts, especially from the more experienced guys here, on how you’d structure something like this. The goal would be a 16–20 week lean mass phase before starting a prep later on. I’ve seen different approaches — single bolus doses, AM/PM splits, timing around workouts with or without insulin, etc. Personally, I’ve always liked the idea of keeping it simple and consistent, with enough time between administrations for receptor resensitization. Like single 18iu bolus subq at night, or postwo, or prewo. Or splitting maximun to 9iu AM and 9iu PM. Another option is 9iu AM and 18iu PM (the highest dose i could pay for)

What’s your take? How would you plan it out theoretically?

Ill share pics of my current shape and progress if that helps — right now I’m sitting at around 95 kg, 8–9% body fat, and 174 cm tall. I’ll also be keeping an eye on markers like IGF-1, glucose, and HbA1c to track how things move.

Please take this as a pure experimental log for discussion purposes — I’m fully aware of the risks and not encouraging anyone to do the same. I just want to share the project, document it, and hopefully get some feedback or theoretical advice from others who’ve explored similar territory. Thanks to everyone who’s willing to help or join in on the discussion!
 
Aesthetically (not necesalary on a muscle building POV), the real game changer would be insulin imo here. 10-12 IU GH + 20 IU log/novor pre and post would yield better results than 25 IU GH a day. I've used up to 22 IU of GH, and from my experience (running generic) DR starts around ~10-12 IU. Even at 20 IU i've hjad no side effects except starting to get acromegalia feature (and getting massive). That was enough for me to drop the dose to 10 and stay away from very high dose HGH. Even if I got to admit, I was really fucking full...
 
Aesthetically (not necesalary on a muscle building POV), the real game changer would be insulin imo here. 10-12 IU GH + 20 IU log/novor pre and post would yield better results than 25 IU GH a day. I've used up to 22 IU of GH, and from my experience (running generic) DR starts around ~10-12 IU. Even at 20 IU i've hjad no side effects except starting to get acromegalia feature (and getting massive). That was enough for me to drop the dose to 10 and stay away from very high dose HGH. Even if I got to admit, I was really fucking full...
13.5iu GH a day plus 12iu Novo pre and post.
500mg Test
250mg Primo

Making insane progress from week to week. Will lower the Primo soon as E2 is slowly going down, getting fuller but on pictures much leaner. I am 300kcal above regular maintance and its nuts
 
Aesthetically (not necesalary on a muscle building POV), the real game changer would be insulin imo here. 10-12 IU GH + 20 IU log/novor pre and post would yield better results than 25 IU GH a day. I've used up to 22 IU of GH, and from my experience (running generic) DR starts around ~10-12 IU. Even at 20 IU i've hjad no side effects except starting to get acromegalia feature (and getting massive). That was enough for me to drop the dose to 10 and stay away from very high dose HGH. Even if I got to admit, I was really fucking full...
Is hgh worth it ? Ive been experimenting with testosterone and some orals but it didnt make me be so huge for the amount of effort i put in. I was still average or something like that. Thanks
 
Have you used insulin before? You’ll definitely need it at these dosages.

Also, you are going to induce unfavorable cardiac morphology changes at these dosages, which you may or may not be aware of. (See link)

I don’t think this makes sense at all but it’s just my opinion. I think you’ll end up with lots of side effects (not just water retention and increased sugar but irreversible cardiac changes) and not much gain beyond what you could get at a third of the dosage.

 
Aesthetically (not necesalary on a muscle building POV), the real game changer would be insulin imo here. 10-12 IU GH + 20 IU log/novor pre and post would yield better results than 25 IU GH a day. I've used up to 22 IU of GH, and from my experience (running generic) DR starts around ~10-12 IU. Even at 20 IU i've hjad no side effects except starting to get acromegalia feature (and getting massive). That was enough for me to drop the dose to 10 and stay away from very high dose HGH. Even if I got to admit, I was really fucking full...
Not problem using insulin, ive done it before but didnt like it…. Just ester retention an puffines, how would you include slin? Just before and after training?
 
Im decided to use between 18-27iu paired or not with insulin, it depends on your arguments about why using it, im on tirze as well to control blood glucose from gh.
 
well insulin makes HGH work better, why not just keep 10iu and add some tiny insulin dosage to increase IGF1 output from same hgh dose?
 
well insulin makes HGH work better, why not just keep 10iu and add some tiny insulin dosage to increase IGF1 output from same hgh dose?
So i supose following this method it would be:

16:00 - 18iu BOLUS DOSE beforeWO with my solid meal
16:45 - 5iu Insulin + Intra workout (50g HBCD + 20g Aminos)
18:30 - 10iu Insulin PostWO + 100g cream of rice and whey
19:30 - Solid meal
 
So i supose following this method it would be:

16:00 - 18iu BOLUS DOSE beforeWO with my solid meal
16:45 - 5iu Insulin + Intra workout (50g HBCD + 20g Aminos)
18:30 - 10iu Insulin PostWO + 100g cream of rice and whey
19:30 - Solid meal
im just starting today fast acting insulin 5iu once per day together with my 8iu HGH.

Based on this research

Insulin up-regulated total and intracellular GHRs in a concentration-dependent manner. It increased surface GHRs in a biphasic manner, with a peak response at 10 nmol/L

With my stats right now (108kg lean) , 4-6iu shot of insulin is optimizing my hepatic HGH expression to the maximum.

So in my theory 5iu once per day is small enough dosage to not make a lot of problems with sensitivity and fat gain in long term, and is pushing the limits of HGH effect.

Check it out and maybe try this first before going into acromegaly zone lol , also it will be way cheaper.

imo, based on this research, 10iu fast acting insulin is way too much, if insulin using for hepatic GH receptor upregulation to maximum
 
im just starting today fast acting insulin 5iu once per day together with my 8iu HGH.

Based on this research

Insulin up-regulated total and intracellular GHRs in a concentration-dependent manner. It increased surface GHRs in a biphasic manner, with a peak response at 10 nmol/L

With my stats right now (108kg lean) , 4-6iu shot of insulin is optimizing my hepatic HGH expression to the maximum.

So in my theory 5iu once per day is small enough dosage to not make a lot of problems with sensitivity and fat gain in long term, and is pushing the limits of HGH effect.

Check it out and maybe try this first before going into acromegaly zone lol , also it will be way cheaper.

imo, based on this research, 10iu fast acting insulin is way too much, if insulin using for hepatic GH receptor upregulation to maximum
Very interesting, this is the kind of comment i wanted to see here.

With chatGPT help:

1️⃣ Context of the study you cited
  • The article discusses insulin modulating the expression of GH receptors (GHR) in human hepatocytes.
  • The maximum effect on surface GHRs occurs at around 10 nmol/L of insulin in the culture medium.
  • This is an in vitro cell model, not a real plasma level in humans.

⚠️ Very important: plasma levels in a human do not directly translate from cell culture levels. What we are doing is a theoretical calculation, not medical advice.

2️⃣ Conversion to theoretical dose

Known data
  • 1 U of insulin = 6 nmol
  • Male, 100 kg
  • Approximate volume of distribution: 0.1 L/kg → 10 L
  • Target concentration: 10 nmol/L
  • Humalog (rapid-acting) is almost fully absorbed subcutaneously (~70–100 %)

Step 1: total amount needed in the body

C \times V_d = 10\ \text{nmol/L} \times 10\ \text{L} = 100\ \text{nmol}

Step 2: convert to insulin units

100\ \text{nmol} \div 6\ \text{nmol/U} = 16.7\ \text{U}

Step 3: adjust for bioavailability (~70%)

16.7 \div 0.7 \approx 23.8\ \text{U}

3️⃣ Theoretical interpretation

  • Theoretical dose to reach 10 nmol/L in a 100 kg man: ≈ 24 U of Humalog, if all insulin were absorbed instantly.
  • This would produce a peak plasma concentration around 10 nmol/L, according to the volume of distribution model.
  • In practice:
    • The actual peak could be lower, because insulin does not distribute instantly.
    • The risk of severe hypoglycemia would be very high if all were injected at once.

4️⃣ Important notes

  • The insulin effects on GHR have been observed in vitro, in isolated cells, with direct exposure.
  • In humans, plasma levels required to replicate this effect could be dangerous.
  • In real life, insulin acts dynamically: it is rapidly degraded, redistributed, and affects multiple tissues.
  • It is not safe to try to reach 10 nmol/L plasma levels with injected insulin just to stimulate GHR.
 
i believe in saying - HGH without insulin
Very interesting, this is the kind of comment i wanted to see here.

With chatGPT help:

1️⃣ Context of the study you cited
  • The article discusses insulin modulating the expression of GH receptors (GHR) in human hepatocytes.
  • The maximum effect on surface GHRs occurs at around 10 nmol/L of insulin in the culture medium.
  • This is an in vitro cell model, not a real plasma level in humans.

⚠️ Very important: plasma levels in a human do not directly translate from cell culture levels. What we are doing is a theoretical calculation, not medical advice.

2️⃣ Conversion to theoretical dose

Known data
  • 1 U of insulin = 6 nmol
  • Male, 100 kg
  • Approximate volume of distribution: 0.1 L/kg → 10 L
  • Target concentration: 10 nmol/L
  • Humalog (rapid-acting) is almost fully absorbed subcutaneously (~70–100 %)

Step 1: total amount needed in the body

C \times V_d = 10\ \text{nmol/L} \times 10\ \text{L} = 100\ \text{nmol}

Step 2: convert to insulin units

100\ \text{nmol} \div 6\ \text{nmol/U} = 16.7\ \text{U}

Step 3: adjust for bioavailability (~70%)

16.7 \div 0.7 \approx 23.8\ \text{U}

3️⃣ Theoretical interpretation

  • Theoretical dose to reach 10 nmol/L in a 100 kg man: ≈ 24 U of Humalog, if all insulin were absorbed instantly.
  • This would produce a peak plasma concentration around 10 nmol/L, according to the volume of distribution model.
  • In practice:
    • The actual peak could be lower, because insulin does not distribute instantly.
    • The risk of severe hypoglycemia would be very high if all were injected at once.

4️⃣ Important notes

  • The insulin effects on GHR have been observed in vitro, in isolated cells, with direct exposure.
  • In humans, plasma levels required to replicate this effect could be dangerous.
  • In real life, insulin acts dynamically: it is rapidly degraded, redistributed, and affects multiple tissues.
  • It is not safe to try to reach 10 nmol/L plasma levels with injected insulin just to stimulate
Grok says so:

Calculating the exact dose to achieve a serum insulin concentration of 10 nmol/L (~290 μIU/mL) is complex due to individual factors (e.g., insulin sensitivity, clearance rate, body weight), but we can approximate based on pharmacokinetic data and your 110 kg body mass.
  1. Insulin Pharmacokinetics (Apidra):
    • Onset: ~10-20 minutes.
    • Peak: ~0.5-1.5 hours, when serum insulin concentration is highest.
    • Duration: ~3-4 hours.
    • Distribution: Insulin distributes primarily into plasma and extracellular fluid (~15-20 L in a 110 kg individual). Peak serum levels depend on dose, absorption rate, and clearance.
  2. Dose Estimation:
    • Insulin Units and Serum Levels: 1 IU of insulin is ~6 nmol of insulin (molecular weight ~5808 Da). For a 110 kg individual, a rough estimate suggests 1 IU Apidra increases peak serum insulin by ~10-20 μIU/mL in insulin-sensitive individuals, but your HGH-induced insulin resistance (from 8 IU/day) may lower this to ~5-15 μIU/mL per IU due to faster clearance.
    • Target: 10 nmol/L ≈ 290 μIU/mL. Studies and clinical data (e.g., insulin clamp studies) suggest 2-4 IU of rapid-acting insulin (e.g., lispro, glulisine) in a 70-100 kg individual achieves peak levels of ~100-200 μIU/mL. For 110 kg with insulin resistance, 3-6 IU Apidra is likely needed to approach ~290 μIU/mL at peak.
    • Conservative Estimate:
      • 3 IU Apidra: May produce 50-100 μIU/mL (3-6 nmol/L), below the target.
      • 5 IU Apidra: Likely produces 100-200 μIU/mL (6-12 nmol/L), encompassing or slightly exceeding 10 nmol/L.
      • 8 IU Apidra: Could produce 200-300+ μIU/mL (12-17+ nmol/L), exceeding the optimal peak and risking a decline in surface GHR expression due to the biphasic response.
 
Intersting. Im on 10iu was thinking of going up to 15iu over the next few months. Ive ran 10 before with amazing results lean out while also gaining muscle at the same time. Hgh is amazing. Im convinced that to get truly massive like 280+ you need a lot of hgh and slin. I really think to get the hyperplasia effect you need to run high doses ive heard 18iu is when hyperplasia starts. Either way if you run it with slin or not you will become massive.
 
i believe in saying - HGH without insulin

Grok says so:

Calculating the exact dose to achieve a serum insulin concentration of 10 nmol/L (~290 μIU/mL) is complex due to individual factors (e.g., insulin sensitivity, clearance rate, body weight), but we can approximate based on pharmacokinetic data and your 110 kg body mass.
  1. Insulin Pharmacokinetics (Apidra):
    • Onset: ~10-20 minutes.
    • Peak: ~0.5-1.5 hours, when serum insulin concentration is highest.
    • Duration: ~3-4 hours.
    • Distribution: Insulin distributes primarily into plasma and extracellular fluid (~15-20 L in a 110 kg individual). Peak serum levels depend on dose, absorption rate, and clearance.
  2. Dose Estimation:
    • Insulin Units and Serum Levels: 1 IU of insulin is ~6 nmol of insulin (molecular weight ~5808 Da). For a 110 kg individual, a rough estimate suggests 1 IU Apidra increases peak serum insulin by ~10-20 μIU/mL in insulin-sensitive individuals, but your HGH-induced insulin resistance (from 8 IU/day) may lower this to ~5-15 μIU/mL per IU due to faster clearance.
    • Target: 10 nmol/L ≈ 290 μIU/mL. Studies and clinical data (e.g., insulin clamp studies) suggest 2-4 IU of rapid-acting insulin (e.g., lispro, glulisine) in a 70-100 kg individual achieves peak levels of ~100-200 μIU/mL. For 110 kg with insulin resistance, 3-6 IU Apidra is likely needed to approach ~290 μIU/mL at peak.
    • Conservative Estimate:
      • 3 IU Apidra: May produce 50-100 μIU/mL (3-6 nmol/L), below the target.
      • 5 IU Apidra: Likely produces 100-200 μIU/mL (6-12 nmol/L), encompassing or slightly exceeding 10 nmol/L.
      • 8 IU Apidra: Could produce 200-300+ μIU/mL (12-17+ nmol/L), exceeding the optimal peak and risking a decline in surface GHR expression due to the biphasic response.
Im in the same boat as you, never liked high doses of insulin, my physique only got worse, but 5iu looks apeling to me with my bolus gh dose before training.

Maybe just gh + 5iu humalog before training is all i need to optimize results without what i didnt like about slin. I can give it a try.

Thanks buddy!

Nevertheless, bolus dose prebed is so convenient for me
 
Intersting. Im on 10iu was thinking of going up to 15iu over the next few months. Ive ran 10 before with amazing results lean out while also gaining muscle at the same time. Hgh is amazing. Im convinced that to get truly massive like 280+ you need a lot of hgh and slin. I really think to get the hyperplasia effect you need to run high doses ive heard 18iu is when hyperplasia starts. Either way if you run it with slin or not you will become massive.
My initial protocol was going to be 18iu prebed and NO slin. Slin makes things more difficult.
 
PLEASE get an EchoCardioGram before starting and one after.
If you are already convinced that you should run this dosage, at least do proper documentation as a warning sign for anyone else who tries this.
And maybe to look back on this and say "well, all those warnings were complete bogus, I just got massive with no Cardiac morphology changes"

maybe add in some long actin Insulin (makes taking it less complicated) if you really dislike short acting insulin and its unpredictability.
 
Back
Top