Safinamide – a clean dopamine booster that actually makes sense?

[Deadpool99]

Something that sounds similar is methylene blue. It does all those things for me anyway. Definitely helped me to feel normal on deca. Feel some extra energy. I use 5 or 10mg. It's also available everywhere and cheap

Was rly interested in it cuz many here love it.

But from what I’ve seen methylene blue is like using a cheap pre-workout that hits a bunch of things at once, it gives you some energy, but it’s messy and easy to overdo. It blocks both MAO-A and MAO-B, so if you take too much or mix it with the wrong stuff, you can get side effects or serotonin issues.

On the other hand. Safinamide is the clean, precision version. It only targets MAO-B, which means it keeps your dopamine steady without messing with serotonin or heart rate, and it also calms down excess glutamate, so you stay sharp, motivated, instead of jittery or burnt out.

Basically IMO, methylene blue is the rough DIY version. Safinamide is the pharmaceutical-grade version that does the same job better, cleaner, and safer. It’s clinical data is just way supportive for a AAS used.

Also some anecdotes dictated that effects can vary a lot. Methylene blue hits people differently because everyone metabolizes it at a different rate or dosing can be all over the place. Some feel great on tiny doses, others get side effects or nothing at all. It’s unpredictable atleast from my POV while looking at others.

 

[IndividualMan]

so if you take too much or mix it with the wrong stuff, you can get side effects or serotonin issues.

tesofensine, sertraline and Methylene blue combo, I wanna go to serotonin syndrome land

 

[Ruru_Teh_seks]

I've already had it, it's nice (sarcastic), now when I feel it coming I take less methylene blue and I manage to manage like that, but you have to be careful, it can be surprising

 

[Banana Joe]

@Deadpool99 I read it like you haven't taken Bup yet, but have you taken Safinamide yet?

I assume you are aware that you have certain dietary restrictions on MAO-Is?

 

[xrayphoton13]

Was rly interested in it cuz many here love it.

But from what I’ve seen methylene blue is like using a cheap pre-workout that hits a bunch of things at once, it gives you some energy, but it’s messy and easy to overdo. It blocks both MAO-A and MAO-B, so if you take too much or mix it with the wrong stuff, you can get side effects or serotonin issues.

On the other hand. Safinamide is the clean, precision version. It only targets MAO-B, which means it keeps your dopamine steady without messing with serotonin or heart rate, and it also calms down excess glutamate, so you stay sharp, motivated, instead of jittery or burnt out.

Basically IMO, methylene blue is the rough DIY version. Safinamide is the pharmaceutical-grade version that does the same job better, cleaner, and safer. It’s clinical data is just way supportive for a AAS used.

Also some anecdotes dictated that effects can vary a lot. Methylene blue hits people differently because everyone metabolizes it at a different rate or dosing can be all over the place. Some feel great on tiny doses, others get side effects or nothing at all. It’s unpredictable atleast from my POV while looking at others.

This sounds like most of your points are in theory or chatgpt. Until you actually try them both and compare in your own body you can't really know which will be better for you. I don't get any of this jitteriness or burnt out sides you speak of with MB. Ive taken it with fluvoxamine(SSRI) and no issues but I know some people could depending on dosing and their body chemistry.
This post just gives me flashbacks to Ghoul saying modafinil is the designer precision caffeine. So I bought some. Several different brands he recommended. Moda. Armoda. Tried solo. Different doses. Different brands. Different mixes of the two. Thought they sucked. Caffeine blows them away... To me. So now I have a crap load of Moda with no use for it. Tried to give it to My wife but she hated it too over caffeine pills. So all I'm saying is while one thing may sound better on paper that doesn't matter if it doesn't in you so feel free to experiment if you like! One might save you a bunch of money over the other

 

[Deadpool99]

This sounds like most of your points are in theory or chatgpt. Until you actually try them both and compare in your own body you can't really know which will be better for you. I don't get any of this jitteriness or burnt out sides you speak of with MB. Ive taken it with fluvoxamine(SSRI) and no issues but I know some people could depending on dosing and their body chemistry.
This post just gives me flashbacks to Ghoul saying modafinil is the designer precision caffeine. So I bought some. Several different brands he recommended. Moda. Armoda. Tried solo. Different doses. Different brands. Different mixes of the two. Thought they sucked. Caffeine blows them away... To me. So now I have a crap load of Moda with no use for it. Tried to give it to My wife but she hated it too over caffeine pills. So all I'm saying is while one thing may sound better on paper that doesn't matter if it doesn't in you so feel free to experiment if you like! One might save you a bunch of money over the other

I was interested in Monda/Armoda but long term use and insomnia risk were my issues.

I wanted smth that is closest to a guarantee as possible and my research indicated MB is good, maybe even proviron but safinamide can actually be neuro-protective as well and actually aid with tren’s affects

I ordered some Safinamide, I’m the type to feel nothing on compounds based on anecdotes and data, placebo ain’t in my vocabulary and I early tolerate drugs normally, always feel like I need more of smth to feel it. So will be interesting to test it out.

​

 

[Banana Joe]

This sounds like most of your points are in theory or chatgpt. Until you actually try them both and compare in your own body you can't really know which will be better for you.

This. I had written up something like this, but hadn't pressed the send button yet, and now the draft is gone.
AFAIK MAO-Is are nowadays rather rarely prescribed by psychiatrists to anyone not hospitalised ,or suffering from severe depression after multiple SSRIs had failed. Bup is AFAIK prescribed A LOT if SSRIs are not wanted or well tolerated.

@Deadpool99 this all sounds convincing, and I believe you have done the best to do your due diligence, but it is far removed from first hand experience in the real world, and likely also real data, that doesn't come from a LLM, which I am unable to provide right now.

You compare a lot of drugs with and to each other, that are nothing alike at all. You make Bup sound almost like crack cocaine. This is certainly not the case.

 

[Deadpool99]

This. I had written up something like this, but hadn't pressed the send button yet, and now the draft is gone.
AFAIK MAO-Is are nowadays rather rarely prescribed by psychiatrists to anyone not hospitalised ,or suffering from severe depression after multiple SSRIs had failed. Bup is AFAIK prescribed A LOT if SSRIs are not wanted or well tolerated.

@Deadpool99 this all sounds convincing, and I believe you have done the best to do your due diligence, but it is far removed from first hand experience in the real world, and likely also real data, that doesn't come from a LLM, which I am unable to provide right now.

You compare a lot of drugs with and to each other, that are nothing alike at all. You make Bup sound almost like crack cocaine. This is certainly not the case.

Ofc this is all theoretical and based on clinical data, anecdotes and the drug’s own labeling. That’s why I slapped a question mark on the post’s title.
And btw, this isn’t AI-generated, I just like reading up on mechanisms and putting things together myself, AI helps me understand the data and I can question the data and why and what’s written with AI to understand further and understand both sides of the argument but I put this all myself.

Yeah, I get what you’re saying, I’m not claiming Safinamide is mainstream or the ultimate drug. I just came across all the data and wanted to put it into perspective for guys like me who would care about improving mood/motivation and who are like me obsess over long-term safety. Cuz safety is number 1 for me if I’m taking these sort of drugs.

And yeah, to clarify, I never intended to imply bupropion and cocaine to be similar or anything close. But the side effects I mentioned aren’t made-up, they’re right there in the drug’s own labeling. It can raise heart rate, blood pressure, anxiety, insomnia, and has a higher seizure risk, especially if someone’s already on Stims or compounds like Clen or T3. That’s just the pharmacology. (Alot of ppl like abusing stims I see)

To me it’s nit just “speculation” or “theory”, Brup does hit dopamine/norepinephrine reuptake directly, so it should feel more stimulating and carries a higher sympathetic load, that’s just how it works.

Of course, how much someone actually feels it depends on individual response, but those effects are within the label itself.

I did however read several anecdotes to determine if Moda/Armoda would cause insomnia and it did.

I will never know for sure unless I try and the pills are on it’s way. But when someone tells me the effects and side effects of a drug like tren, I should severely consider it, but again I don’t get any sides of tren. So it’s individual based but some mechanisms like the neuro-toxicity of tren won’t be felt when using but will accumulate long term. You don’t need to feel it to know if it’s true or not.

 

[Banana Joe]

Tren and other 19-nors can wreck dopamine balance and crank up glutamate, which is what causes the irritability, anxiety, and brain fog. Safinamide helps level that out and might even be neuroprotective, basically helps your brain tolerate the cycle better.

How does your data then explain why Trenbolone and Nandrolone can have almost diametrical effects on someones brain?

Ofc this is all theoretical and based on clinical data, anecdotes and the drug’s own labeling. That’s why I slapped a question mark on the post’s title.
And btw, this isn’t AI-generated, I just like reading up on mechanisms and putting things together myself, AI helps me understand the data and I can question the data and why and what’s written with AI to understand further and understand both sides of the argument but I put this all myself.

Yeah, I get what you’re saying, I’m not claiming Safinamide is mainstream or the ultimate drug. I just came across all the data and wanted to put it into perspective for guys like me who would care about improving mood/motivation and who are like me obsess over long-term safety. Cuz safety is number 1 for me if I’m taking these sort of drugs.

And yeah, to clarify, I never intended to imply bupropion and cocaine to be similar or anything close. But the side effects I mentioned aren’t made-up, they’re right there in the drug’s own labeling. It can raise heart rate, blood pressure, anxiety, insomnia, and has a higher seizure risk, especially if someone’s already on Stims or compounds like Clen or T3. That’s just the pharmacology. (Alot of ppl like abusing stims I see)

To me it’s nit just “speculation” or “theory”, Brup does hit dopamine/norepinephrine reuptake directly, so it should feel more stimulating and carries a higher sympathetic load, that’s just how it works.

Of course, how much someone actually feels it depends on individual response, but those effects are within the label itself.

I did however read several anecdotes to determine if Moda/Armoda would cause insomnia and it did.

I will never know for sure unless I try and the pills are on it’s way. But when someone tells me the effects and side effects of a drug like tren, I should severely consider it, but again I don’t get any sides of tren. So it’s individual based but some mechanisms like the neuro-toxicity of tren won’t be felt when using but will accumulate long term. You don’t need to feel it to know if it’s true or not.

First, AIs are sycophantic and will agree with the wildest theories about drugs. Just recent anecdote because it is such an idiotic one:
It took me probably close to half a dozen prompts, to get AI to agree with me that 1mg of DMZ cannot (roughly) have the same amount of molecules than Superdrol - if DMZ is basically two Sdrol molecules bonded together (which it is). Any idiot would be able to realise that DMZ must haveroughly half the amount of molecules per 1mg.

Second, let's forget the pharmacodynamics of these drugs, but let's focus on how they make one feel.
I will not debate your longterm-outcome, of taking such drugs in terms of damage, because I simply don't know, and can therefore not debate you on this. You will understand that I will not go on a days long ChatGPT spree, to find supporting data to convince you.
But where do you get these descriptions like precise, sharp, DIY version, cleaner, etc. from, have you tried any of them yourself?

Third, even leaving aside that these words, to describe how these drugs make one "feel", are so far away from how they make me feel - if someone tells you that psychiatrists prescribe nothing like they should, if your assessments were correct, doesn't that make you question the validity of said assessments?

Fourth, what scientific sources can you cite for the feelz, if not from descriptions in regards to patients with a clinical depression, whose brain doesn't work like it should.
Biohacking forums and reddit?

Fifth, I may be misreading your posts regarding this, but I read it like MAOIs are just the smoother gentler version of Bupropion. This is so far away from the truth, as anything. They are an ENTIRELY different class of drugs.

Show these findings to *any* doctor, not just psychiatrists, and he will tell you the same.

Don't you think, if there would be drug to make someone not go nuts from using Tren, that someone else would have already discovered it?

 

[Banana Joe]

Feel free to poke holes into this, I already spend way to much time on writing this, and didn't go through two rounds of checkings, that I would normally do.

I will nevertheless stand by the gist of my two last posts.

 

[Deadpool99]

How does your data then explain why Trenbolone and Nandrolone can have almost diametrical effects on someones brain?

Isn't it cuz Nand is stimulates progestin and isn't rly androgenic in the brain, so it tends to calm you down or make you kinda flat if dopamine dips.
And Tren is the opposite, more androgenic in the brain thus hits dopamine and glutamate harder?

 

[Deadpool99]

Second, let's forget the pharmacodynamics of these drugs, but let's focus on how they make one feel.
I will not debate your longterm-outcome, of taking such drugs in terms of damage, because I simply don't know, and can therefore not debate you on this. You will understand that I will not go on a days long ChatGPT spree, to find supporting data to convince you.
But where do you get these descriptions like precise, sharp, DIY version, cleaner, etc. from, have you tried any of them yourself?

Ur right bro, those aren’t my personal experiences as I said previously. I haven’t tried it yet. I use AI to help me put what I read and understand into better words. It just helps me describe what something should feel like based on the mechanism and other people’s reports. Once I run it myself, I’ll post an honest take from experience.

I also did read the entire MB thread about people’s experiences which left questioning.

 

[Banana Joe]

Just to be clear, I am not saying that your assertion is wrong, that Safinamide could actually be a potential drug, that lessens the mental side effects of Trenbolone, since I am NOT well versed in neurochemistry, and the neurosteroidal properties of Trenbolone.
In fact, now that I had a closer look and realise I didn't see you mentioning it is a Parkinson's disease drug, rather than an anti-depressant drug, I do acknowledge that there is possibility that it theoretically could potentially work. But I can also say with certain confidence that some other assertions of your are so far removed from what I know to be true, that I therefore have to question the plausibility of your assessment of Safinamide.

Trust me, I tried to do similar things with AI, and one of the outcomes was that I was quite sure to have found a novel drug (as in not yet approved where I live) for a certain purpose. Then I talked to an professional who flat out shrugged his shoulders and told me, that he expects something like that to not even budge the needle in this particular case.
I would also almost bet I prompted AI more than you about Trenbolone and its effects on the brain, also in combination with multiple other drugs. The only thing I can tell you about my findings is, that they were inconclusive.

Ur right bro, those aren’t my personal experiences as I said previously. I haven’t tried it yet.

Again, this is not a knock on you, but I have experience with surely more than half of all the compounds named in this thread. Admittedly, this is course personal and anecdotal, I can tell you that your assessment of the compounds I know, doesn't match with my personal experience, not even in a single case.

 

[Deadpool99]

Just to be clear, I am not saying that your assertion, that Safinamide could actually be a potential drug, that lessens the mental side effects of Trenbolone, since I am well versed in neurochemistry, and the neurosteroidal properties of Trenbolone.
In fact, now that I had a closer look and realise I didn't see you mentioning it is a Parkinson's disease drug, rather than an anti-depressant drug, I do acknowledge that there is possibility that it theoretically could potentially work. But I can also say with certain confidence that some other assertions of your are so far removed from what I know to be true, that I therefore have to question the plausibility of your assessment of Safinamide.

Trust me, I tried to do similar things with AI, and one of the outcomes was that I was quite sure to have found a novel drug for something. Then I talked to an professional who flat out shrugged his shoulders and told me, that he expects something like that to not even budge the needle in this particular case.
I would also almost bet I prompted AI more than you about Trenbolone and its effects on the brain, also in combination with multiple other drugs. The only thing I can tell you about my findings is, that they were inconclusive.


Again, this is not a knock on you, but I have experience with surely more than half of all the compounds named in this thread. Admittedly, this is course personal and anecdotal, I can tell you that your assessment of the compounds I know, doesn't match with my personal experience, not even in a single case.

No, of course I never claimed something was 100% accurate or that I was quoting facts on the contrary, it may seem I am fully confident in my assessment, but I was purely seeking the best option.

I was just laying out the information I gathered, I was trying to find out whether what I gathered could be beneficial.

I would also like what your thoughts on the compound we’re speaking of? Do you think it has potential?

I know that you guys like MB more but I’m the type of guy who doesn’t try shit alot, and basically like the science and clinical data and the pathways that the drugs work on, and I found this to be on paper the best option, but again as you said AI and research can sat something but at the end of the day experience and as you said you can go to a psychiatrist and they’ll debunk half of the shit you just gathered.

Hopefully my anecdote, after trying, could prove beneficial.

And also you mentioned a good point that many people seek to remedy the issue of tren, but also this compound hasn’t been talked about at all and seems to be hard to source too, so that might also be a reason why people don’t really look at it at first glance.

Btw I forgot to ask, did you try Bup? If ao, what was ur experience with it. I got a bottle of it in my cupboard.

 

[Banana Joe]

For clarity's sake, I had forgotten a "NOT" in my first paragraph!

 

[Deadpool99]

I guess also when you research and the AI throws the word neuro-protective, my curiosity is automatically triggered.

I had similar findings, I was debating other common compounds that would yield similar effects people often praised: for example Rasagiline and Selegiline.

 

[Banana Joe]

I guess also when you research and the AI throws the word neuro-protective, my curiosity is automatically triggered.

I had similar findings, I was debating other common compounds that would yield similar effects people often praised: for example Rasagiline and Selegiline.

Here ya go with another one, did you find this as well?

Memantine, as an NMDA receptor antagonist, blocks excessive activation of glutamate receptors implicated in neurotoxicity and neuronal damage. Trenbolone, an anabolic steroid, has been reported to cause psychiatric and cognitive side effects, possibly linked to neurotransmitter imbalances, excitotoxicity, or oxidative stress.

In theory, memantine could mitigate some mental side effects of trenbolone if they are related to glutamate-induced excitotoxicity or NMDA receptor overactivation because memantine selectively blocks pathological NMDA receptor activity without impairing normal function. However, there is no direct clinical or experimental evidence specifically studying memantine's effect on trenbolone-induced mental side effects.

 

[Deadpool99]

Here ya go with another one, did you find this as well?

Actually no, surprisingly first time reading this.
I guess I'll be doing some experimentation.

Also I asked once but just wanted to ask again out of curiosity since you might have missed it. Have you tried Bupropion before?

 

[Banana Joe]

Was rly interested in it cuz many here love it.

Quoted for Trenbolone truth!

Actually no, surprisingly first time reading this.

Did I now make my point, when claiming I fucked around with AI and Tren a lot?^^

Also I asked once but just wanted to ask again out of curiosity since you might have missed it. Have you tried Bupropion before?

Yes, I have seen your question. I just didn't know what to answer.

To make it short: Yes.

The longer answer is that my personal experience would be very likely of little to no use for you, because I react to most, if of not all the drugs named so far very differently, than most people likely would.
I can tell you that I have been prescribed higher, than the clinically trialed doses, of Bup, simultaneously with a decent amount of Tren, but I react like maybe 1:100, or rather likely less than that, when taking Tren (mentally), and you can add at least another zero for Bup (physically).

So I am not sure what conclusions for the majority of BBs running Tren could be drawn from that. In fact I don't I even knew about Tren's common mental side effects until a few years ago, despite having taken it now almost 2 decades ago already. Since I didn't notice any cognitive change, I just never gave it a second thought. I just remembered what it did to my physique already at a rather low dose.
Only when I delved back into PEDs a couple of years ago, I learned about Tren making people getting mental. If I were a betting man, I would bet that taking or Safinamide and especially Memantine would lead to similarly different outcomes.

I think Vigorous Steve claims that Fluvoxamine helps with Tren's side effects, but mechanistically I can't really see why that might actually be the case.
At least on paper Safinamide and Memantine should be much better candidates. Knowing myself a bit by now, I would put my money on Memantine for my particular case, and probably also in general.


*which is not really addictive but an amphetamine

 

[Deadpool99]

Quoted for Trenbolone truth!


Did I now make my point, when claiming I fucked around with AI and Tren a lot?^^


Yes, I have seen your question. I just didn't know what to answer.

To make it short: Yes.

The longer answer is that my personal experience would be very likely of little to no use for you, because I react to most, if of not all the drugs named so far very differently, than most people likely would.
I can tell you that I have been prescribed higher, than the clinically trialed doses, of Bup, simultaneously with a decent amount of Tren, but I react like maybe 1:100, or rather likely less than that, when taking Tren (mentally), and you can add at least another zero for Bup (physically).

So I am not sure what conclusions for the majority of BBs running Tren could be drawn from that. In fact I don't I even knew about Tren's common mental side effects until a few years ago, despite having taken it now almost 2 decades ago already. Since I didn't notice any cognitive change, I just never gave it a second thought. I just remembered what it did to my physique already at a rather low dose.
Only when I delved back into PEDs a couple of years ago, I learned about Tren making people getting mental. If I were a betting man, I would bet that taking or Safinamide and especially Memantine would lead to similarly different outcomes.

I think Vigorous Steve claims that Fluvoxamine helps with Tren's side effects, but mechanistically I can't really see why that might actually be the case.
At least on paper Safinamide and Memantine should be much better candidates. Knowing myself a bit by now, I would put my money on Memantine for my particular case, and probably also in general.


*which is not really addictive but an amphetamine

Appreciate it, thanks again for all the help.