MESO-Rx

Anabolic Steroids

Using estradiol injection to allow for low test cycles

rexy said:
That's some great feedback to support it! Thanks for responding.

Have you tried MENT in place of injectible E2 at any point? I'm giving that a go now whilst i wait on some ECyp to arrive, but have only just started, and my last testosterone dose is still to fully clear so it's not a fair comparison yet.

Do you feel that could be another option to run with the compounds for an estrogen source that increases SHBG in place of test, if the user tolerates it? Granted it's potentially harder to manage and it's methylestrogen, but the upside is additional anabolism from the compound.

I've started 30mg Ralox ED alongside it because I've heard so many horror stores, but so far I'm doing 12.5mg MENT everyday alongside 50mg Tren A, and will ramp it up as the testosterone clears. No issues so far and strength/reps are progressing workout-to-workout above my average progression on my usual standard cycle of 600 Test/200 Tren
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Ive run ment 2 times. First time was with 630 Test+ 280 Ment back in October-November 2022. I aromatize very low. 750 test without ai id done prior and e2 was 45-50.1pg/ml. I figured it would be ok for me but this gave me proper gyno flare up for the first time. Very itchy nips and grand growth.

Second run with Ment was started on
-12/27/24
350ment-875boldcyp-1050dhb+3.5mg EstradiolCyp( immediately prior to this was on 1880boldcyp-907dhb-3.5Estradiol cyp)

-1/14/25
Switch to:
350ment-2100primo+3.5mg EstradiolCyp

2/25/25
Switch to:
525trenhex-2100primo+3.5mgEstradiolCyp

So when I ran Ment this 2nd time I had estradiol in play, and also had either high dose boldenone+dhb or high dose primo. In my mind, I wanted this because I expected the bold/dhb/primo to eliminate most of the methylE2 from ment. dhb/bold/primo did seem to work to clean up the methylE2 because I didn’t get added estrogenic sides which is always gyno flares first fir me. Also, a few weeks in here I took 25mg aromasin eod within this period to just “make sure” the methylE2 was being mostly eliminated, and I didn’t notice the aromasin doing anything which tells me the dhb/bold/primo did its job.

Which brings me to the next point: if using ment as an estrogen base, that leaves trenbolone, nandrolone, maybe masteron, var, superdrol, tbol, or Anadrol as the secondary anabolic that can be used without potentially crushing the methylE2 of ment. Unless you run a higher dose of ment with primo/bold etc and treat ment just like its test.

Basically I haven’t just tried to rely on methylE2 yet as my only source of estrogen yet.
 
craigdt said:
Well like the true scientific pioneer (idiot?) that I am, I'm going to start injecting .2mg estradiol cypionate per day for the next week or so.

I've got low energy, not a lot of sex drive (but perfectly functioning junk), would like to see if I could improve those a bit.

If no sides/felt impact, I'll slowly up it.

Thinking I likely have low E2, due to my test/primo/eq cycle currently.

I could throw dbol in there but I dont want any orals right now.

Could up my hcg, but I feel best on about 1000mcg per week.

Could up my test lower my primo or eq, but I dont want to.

I'll report back with my giant anime tiddies.
Click to expand...
0.2mg daily might be too high. A way I’ve recommended people start is first find the e2 dose by doing labs at week3-4 then only adjusting dose after those labs. If high/low sides occurs before this, get labs anyway then adjust dose.

In myself 1mg injectable e2per week give me 18-21pg/ml e2 sensitive labs. For a client, 27pg/ml per 1mg injectable e2 per week was the highest…

More recently I’ve seen someone get 213pg/ml from 4.2mg per week e cyp( 1.2mg eod blood pulled at trough) this equals 51pg/ml per 1mg injectable estradiol per week.
 
Para_33 said:
Ive run ment 2 times. First time was with 630 Test+ 280 Ment back in October-November 2022. I aromatize very low. 750 test without ai id done prior and e2 was 45-50.1pg/ml. I figured it would be ok for me but this gave me proper gyno flare up for the first time. Very itchy nips and grand growth.

Second run with Ment was started on
-12/27/24
350ment-875boldcyp-1050dhb+3.5mg EstradiolCyp( immediately prior to this was on 1880boldcyp-907dhb-3.5Estradiol cyp)

-1/14/25
Switch to:
350ment-2100primo+3.5mg EstradiolCyp

2/25/25
Switch to:
525trenhex-2100primo+3.5mgEstradiolCyp

So when I ran Ment this 2nd time I had estradiol in play, and also had either high dose boldenone+dhb or high dose primo. In my mind, I wanted this because I expected the bold/dhb/primo to eliminate most of the methylE2 from ment. dhb/bold/primo did seem to work to clean up the methylE2 because I didn’t get added estrogenic sides which is always gyno flares first fir me. Also, a few weeks in here I took 25mg aromasin eod within this period to just “make sure” the methylE2 was being mostly eliminated, and I didn’t notice the aromasin doing anything which tells me the dhb/bold/primo did its job.

Which brings me to the next point: if using ment as an estrogen base, that leaves trenbolone, nandrolone, maybe masteron, var, superdrol, tbol, or Anadrol as the secondary anabolic that can be used without potentially crushing the methylE2 of ment. Unless you run a higher dose of ment with primo/bold etc and treat ment just like its test.

Basically I haven’t just tried to rely on methylE2 yet as my only source of estrogen yet.
Click to expand...

Really appreciate the detail you put into that response, thank you. I will keep these things in mind whilst I try some of these different cycles out!

I'm going to experiment with a few things.

- MENT as the base, with Tren/Nandrolone as main anabolic. Currently, MENT + Tren seems to be treating me well without signs of estrogen issues, or any issues whatsoever. So far I feel the best i have on cycle, but that may be the small background dose of testosterone yet to fully clear, 30mg of ralox blunting the increase E2 risk of gyno, and the low dose of MENT. I'm mainly leveraging the power of Tren for the anabolism.

- I'm definitely considering the use of primo/bold alongside MENT to allow a higher dose of MENT to be used, to mimic something in line with what LGOP suggested, but maybe with lower Test:
Test E 550
Trest E 245
Bold cyp 350
Small primo shots and AIs strategically.

- and finally, the E-Cyp route where I use something akin to your cycles, so like:
Tren A or Nandrolone
EstradiolCyp

Should be interesting to see what happens. This is alongside 9-12IU per day of HGH and my cardiac response is much better with the testosterone being lower. I thought the increased Tren and the MENT would add more adrenergic stimulus, but I feel calmer than I ever have at present, and managing RHR is tons easier even though I'm at peak Tren dose.
 
Sampei said:
So I have been thinking of a new possible approach for using some substances that are usually a bit tricky due to the lowering estrogen ability they have attached to their use so that one could use high dose of these mild compounds without having to blast test very high.

EQ and Primo are the main focus of this brainstorm idea I'm having, but Nandrolone can be another one.

So I can't run any of these two substances on a ratio of 1:1 without killing my E2.
I have noticed that both substances are great run at high dosages with minimum impacts on bloods especially EQ for me is a breeze with no side effect except those damn low E2.

I have been thinking, why not run 500mg of test as a base and then 1.5G of EQ for example and to balance E2 just inject low dosages of estradiol cypionate?

You could run a very high anabolic cycle with minimal sides and still have a healthy level of E2.

Please rip me a new one or give me your criticism/ideas on this approach.
Click to expand...
Hello! I'd love to share my experience with this idea -

So I just came off my first cycle which started at 300 cyp, and ran that for about 20 weeks. Thought I'd throw 300mg primo in for the last 8 weeks to finish off, but the first week after pinning it I got terrible low E2 symptoms; got bloodwork and had a estradiol of like 3. I'm a big fan of Dtren and was inspired by his cycle of trt + high primo + oral E2 but could only get injectable estradiol valerate quick, so ended up running that for the rest of my cycle. Started off with 0.5mg EV/week split into EOD injections, which put my E2 at 18 but I felt great. Bumped it up to 1mgEV/week for the last couple weeks of my cycle and felt even better.

Gonna be cruising for the next few weeks but on my next cycle I'm planning to do a long cycle of 180 test + 500 primo with oral E2 this time around, messaged Dawson about this and he said he prefers oral and will take it preworkout for better mood and intensity during his lifts. I figure if any liver issues I can just switch back to injectable.

Hope this helps!
 
Raiders789 said:
Gonna be cruising for the next few weeks but on my next cycle I'm planning to do a long cycle of 180 test + 500 primo with oral E2 this time around, messaged Dawson about this and he said he prefers oral and will take it preworkout for better mood and intensity during his lifts. I figure if any liver issues I can just switch back to injectable.
Click to expand...
This should work fine although I haven't tried oral E2. I recently added in 500 EQ + 300 Primo into my cycle and added 1mg Estradiol Cyp in per week. It's helped my mood a lot.

It does indeed work well. I still have a 400mg Test base which shows how strongly the EQ and Primo affect it, although I'm letting that taper off to see how it is with lower Test. The good thing now is those other compounds can be dosed to whatever I want, and E2 is consistent.

One thing I have absolutely noticed is lack of HR stimulation whilst adding in E-Cyp and titrating down Test and that is a game changer for me. I've been able to remove Ivabradine completely with letting the Test drop. Even with 10IU HGH each day, and 75mg Tren Ace on workout days, I no longer get the HR stimulation from either. Which makes me think Test is either the main culprit for jacking up adrenergic response and Tren and or HGH takes the blunt of the blame because they are usually always combined with it, or they each at least synergise with Test in a negative way on HR.
 
Last edited:
rexy said:
This should work fine although I haven't tried oral E2. I recently added in 500 EQ + 300 Primo into my cycle and added 1mg Estradiol Cyp in per week. It's helped my mood a lot.

It does indeed work well. I still have a 400mg Test base which shows how strongly the EQ and Primo affect it, although I'm letting that taper off to see how it is with lower Test. The good thing now is those other compounds can be dosed to whatever I want, and E2 is consistent.

One thing I have absolutely noticed is lack of HR stimulation whilst adding in E-Cyp and titrating down Test and that is a game changer for me. I've been able to remove Ivabradine completely with letting the Test drop. Even with 10IU HGH each day, and 75mg Tren Ace on workout days, I no longer get the HR stimulation from either. Which makes me think Test is either the main culprit for jacking up adrenergic response and Tren and or HGH takes the blunt of the blame because they are usually always combined with it, or they each at least synergise with Test in a negative way on HR.
Click to expand...
Have you noticed that it has any impact on systolic blood pressure ? That’s really interesting, I plan on running something similar this winter.
 
Gonz0 said:
Have you noticed that it has any impact on systolic blood pressure ? That’s really interesting, I plan on running something similar this winter.
Click to expand...
Nope. BP has remained the same, but I wouldn't use me as an example for that because my BP is very difficult to budge. I'm lucky in terms of genetics r.e blood pressure.

It stays at an average of 105/60 no matter what I do.
 
rexy said:
Nope. BP has remained the same, but I wouldn't use me as an example for that because my BP is very difficult to budge. I'm lucky in terms of genetics r.e blood pressure.

It stays at an average of 105/60 no matter what I do.
Click to expand...
You’re blessed man, I have a family history of high blood pressure so I always try and stay on top of it while on cycle. Last winter I ran eq for the first time (1000/300 test/eq) and ended up crashing my e2. It was my first experience with crashing my estrogen and my systolic was pretty high. I’m thinking if I run something similar it may benefit me seeing how I could run my test relatively low and always have e2 in a good spot. Appreciate the info.
 
craigdt said:
Well like the true scientific pioneer (idiot?) that I am, I'm going to start injecting .2mg estradiol cypionate per day for the next week or so.

I've got low energy, not a lot of sex drive (but perfectly functioning junk), would like to see if I could improve those a bit.

If no sides/felt impact, I'll slowly up it.

Thinking I likely have low E2, due to my test/primo/eq cycle currently.

I could throw dbol in there but I dont want any orals right now.

Could up my hcg, but I feel best on about 1000mcg per week.

Could up my test lower my primo or eq, but I dont want to.

I'll report back with my giant anime tiddies.
Click to expand...
That's 4x my wife's dose...
 
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