Blood Pressure

To ask the other way around:

Where is the BP threshold for a 100kg male, where it would become too low for optimal gym performance?

Where is are longevity and performance well balanced?

Statistically lowest all cause mortality is 115-120 systolic, 70 diastolic For best physical readiness systolic is just slightly higher 120-125, and ideal diastolic is still 70.

Irrespective of body size.

High heart rate variability (HRV) and good vascular tone (elastic arteries) is what matters for physical performance. Nitric Oxide levels in blood vessels, preventing high BP, low lipids, all contribute to flexible arteries.
 
Ahh crap. You definitely did list all of that this morning. My bad bro. I've been trying to keep up with this thread while at work. It looks like you've got some solid options going forward.
It is all good, I often miss posts as well!

Statistically lowest all cause mortality is 115-120 systolic, 70 diastolic For best physical readiness systolic is just slightly higher 120-125, and ideal diastolic is still 70.

Irrespective of body size.
Ok, then 120/70 it is, or as close as possible. I also need this Cilnidipine, since it apparently prevents and can apparently also regress plaque. LDL will also be taken care of with Pita/Ezem. Don't need that stroke from Nebi, I guess.

I now wanna go all in with this stuff. Since I can't really run anabolics atm, I need to be at least running the most potent health stack!
 
Ok, then 120/70 it is, or as close as possible. I also need this Cilnidipine, since it apparently prevents and can apparently also regress plaque. LDL will also be taken care of with Pita/Ezem. Don't need that stroke from Nebi, I guess.

I now wanna go all in with this stuff. Since I can't really run anabolics atm, I need to be at least running the most potent health stack!
i don’t think its the nebivolol itself causing the stroke.

i think its the using it as a bandaid of slapping it on top of stiff arteries.
 
i don’t think its the nebivolol itself causing the stroke.

i think its the using it as a bandaid of slapping it on top of stiff arteries.

Beta blockers don't lower blood pressure in the aorta as much as they do in the arm. High pressure pulses hit the delicate arteries in the brain, raising stroke risk and also cause microscopic blood vessel ruptures that slowly accumulate causing cognitive decline.

IMG_2913.webp
 
Beta blockers don't lower blood pressure in the aorta as much as they do in the arm. High pressure pulses hit the delicate arteries in the brain, raising stroke risk and also cause microscopic blood vessel ruptures that slowly accumulate causing cognitive decline.

View attachment 352902
Did we all read the summary or are you all being completely retarded? And can we stop grouping up beta blockers all together Nebivolol included? When it's clear that Nebivolol is on a class of his own and there are plenty of studies of the direct benefit of using it as an add-on if it doesn't reduce the HR too much.
 
Given Telmisartan is apparently the first line of defense in pretty much any case, will I likely be better off with adding Cilnidipine or Nebivolol?
Given my BP is not really a cause for concern (yet), I am reading it like T+C would be the better option over T+N.

I neither really want a stroke nor cankles. All my efforts too look good in the gym, would have been in vain, if either of those would happen.
 
Given Telmisartan is apparently the first line of defense in pretty much any case, will I likely be better off with adding Cilnidipine or Nebivolol?
Given my BP is not really a cause for concern (yet), I am reading it like T+C would be the better option over T+N.

I neither really want a stroke nor cankles. All my efforts too look good in the gym, would have been in vain, if either of those would happen.

Ciln. Not because of the very small increased risk of stroke, but because Cilnidipine (and Telm) reduce BP proportionately instead of by a fixed amount.

"During anabolic steroid use, blood pressure often fluctuates widely, rising sharply during cycles of high androgen levels and sometimes dropping off between them. In that context, angiotensin receptor blockers (ARBs) like telmisartan and calcium channel blockers (CCBs) like cilnidipine tend to behave in a pressure-proportional way: the higher the pressure, the more strongly they lower it. These drugs act mainly on the blood vessels themselves, relaxing arterial walls and countering the hormonal tightening that drives steroid-related hypertension. When pressure normalizes, their effect naturally tapers off, so they rarely push blood pressure too low.

By contrast, beta-blockers such as nebivolol reduce pressure primarily by slowing the heart and blunting stress hormones rather than directly relaxing arteries. This produces a more fixed reduction in pressure regardless of how high it starts, so when the baseline falls, for instance between cycles or during rest periods, the same dose can cause overshooting and hypotension. In short, ARBs and CCBs automatically scale their effect to the degree of hypertension, allowing you to stay on the same dose year round, while beta-blockers deliver a steadier brake that doesn’t adapt as easily to the large swings typical of AAS use."
 
Ciln. Not because of the very small increased risk of stroke, but because Cilnidipine (and Telm) reduce BP proportionately instead of by a fixed amount.

"During anabolic steroid use, blood pressure often fluctuates widely, rising sharply during cycles of high androgen levels and sometimes dropping off between them. In that context, angiotensin receptor blockers (ARBs) like telmisartan and calcium channel blockers (CCBs) like cilnidipine tend to behave in a pressure-proportional way: the higher the pressure, the more strongly they lower it. These drugs act mainly on the blood vessels themselves, relaxing arterial walls and countering the hormonal tightening that drives steroid-related hypertension. When pressure normalizes, their effect naturally tapers off, so they rarely push blood pressure too low.

By contrast, beta-blockers such as nebivolol reduce pressure primarily by slowing the heart and blunting stress hormones rather than directly relaxing arteries. This produces a more fixed reduction in pressure regardless of how high it starts, so when the baseline falls, for instance between cycles or during rest periods, the same dose can cause overshooting and hypotension. In short, ARBs and CCBs automatically scale their effect to the degree of hypertension, allowing you to stay on the same dose year round, while beta-blockers deliver a steadier brake that doesn’t adapt as easily to the large swings typical of AAS use."
Ok, that sums it up nicely, what I could not have worded like that. Thanks!

PS: Please try to use italic, when you quote. Makes it so much nicer to read. :)
 
Given Telmisartan is apparently the first line of defense in pretty much any case, will I likely be better off with adding Cilnidipine or Nebivolol?
Given my BP is not really a cause for concern (yet), I am reading it like T+C would be the better option over T+N.

I neither really want a stroke nor cankles. All my efforts too look good in the gym, would have been in vain, if either of those would happen.

Most people here use N to reduce RHR instead of BP (when running HGH or Reta, both of which increases RHR).
 
Most people here use N to reduce RHR instead of BP (when running HGH or Reta, both of which increases RHR).
Yes, I had already asked about this too, but I guess nobody noticed it.
I figured nobody that is somewhere on the BB spectrum has a RHR that is *too* low.

Leaving aside the possible regular side effects, am I likely to profit from 5mg [of Nebivolol]? Wouldn't it be better to have my RHR [60+-ish] a bit lower?
 
Nebivolol doesn't do anything for my RHR for whatever reason, but bisoprolol makes some impact.

Ivabradine makes the most impact on my RHR but I think I must have had a some strips that lost efficacy for whatever reason, stopped doing anything for a few weeks. New order came in and back to working.
 
I see Nebivolol is something that was constantly recommended, is it worth taking if your RHR is less than 100? any health benefits of lowering your HR with pharmacology?
 
beta blocker

my doctor added metoprolol to my telmisartan when the max dose of telmi failed to produce sufficient lowering of blood pressure.

They seem to work well together.

In plain English, is there some concern about me taking metoprolol ??? Stroke? What is this about?
 
And is Cilnidipine available now in October of 2025? I have been away for a while and have not kept up with all of the trials and tribulations of customs and tariffs and so on.
 
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