Blood Pressure

[Lifting88]

I disagree on "not a good brand". There are tons of lab results showing proper dosing across many products.

There were a couple of underdosed results for Accufine, an extremely cheap drug, not exactly a target for fraud, but also very susceptible to rapid heat degradation. Some have extrapolated that isolated problem to all 800+ products Healing Pharma offers.

I have their 20mg Cilnidipine and my blood pressure responded exactly as expected.

I prefer combo pills however, and I wanted a somewhat unusual dose of Cilnidipine 20 / Telmisartan 40. The most common are Ciln 10 / Telm 40 or Ciln 10 / Telm 80.

I greatly prefer the overall "feel" of Ciln 20, and more than Telm 40 in combination was too strong.

I use Cilicar T 20/40 from JB Pharma, a "Premium" manufacturer of blood pressure meds in India. I would have gotten this from Healing if they offered it, but this was the only 20/40 combo I could find anyone had in stock. It works perfectly.

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I have this brand in 40/10
And cliniheal from healing

 

[Sera]

I disagree on "not a good brand". There are tons of lab results showing proper dosing across many products.

There were a couple of underdosed results for Accufine, an extremely cheap drug, not exactly a target for fraud, but also very susceptible to rapid heat degradation. Some have extrapolated that isolated problem to all 800+ products Healing Pharma offers.

I have their 20mg Cilnidipine and my blood pressure responded exactly as expected.

I prefer combo pills however, and I wanted a somewhat unusual dose of Cilnidipine 20 / Telmisartan 40. The most common are Ciln 10 / Telm 40 or Ciln 10 / Telm 80.

I greatly prefer the overall "feel" of Ciln 20, so rather than Ciln 10 / Telm 80 to get to my target BP, I lowered Telm dose and increased Ciln dose.

I use Cilicar T 20/40 from JB Pharma, a "Premium" manufacturer of blood pressure meds in India. I would have gotten this from Healing if they offered it, but this was the only 20/40 combo I could find anyone had in stock. It works perfectly.

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I find some of these blisters really aesthetically pleasing.

 

[Sera]

I’m beginning to trial cilnidipine 5mg (cilaheart) to see if it helps my reactive hypertension (my baseline blood pressure on waking isn’t high, but can spike due to stress or caffeine). This is my first day using so a little early and maybe things will change but we’ll see.

So far it’s working great, it surprisingly didn’t drop my blood pressure much at all but is blunting sympathetic activity from my morning caffeine, my vessels aren’t constricting much and my heart isn’t reacting much. I wish I tried it sooner!

I took a little while to adapt to tadalafil actually and it made me feel light headed etc for a while so I thought it would be a similar unpleasant process so I was avoiding it.

 

[newguy2]

I am running my first cycle, 500mg test. BP has been fine I am 11 weeks in. Wednesday I did 50mg shot of Deca. Having some joint issues and going to start at 50mg a week to see if it helps.

Did my BP a few days later and it is very high. This morning was 147/80

Previously was 120-130/60~

Not sure what to do. I do not have nor have I taken BP meds before. I would probably sooner drop the deca than get on them. Any advice?

 

[Sera]

I am running my first cycle, 500mg test. BP has been fine I am 11 weeks in. Wednesday I did 50mg shot of Deca. Having some joint issues and going to start at 50mg a week to see if it helps.

Did my BP a few days later and it is very high. This morning was 147/80

Previously was 120-130/60~

Not sure what to do. I do not have nor have I taken BP meds before. I would probably sooner drop the deca than get on them. Any advice?

You can always keep some blood pressure meds around to help short term while you fix your doses, you don’t need to stay on them.

Telmisartan and nebivolol if you want some heart rate control as well.

Otherwise you would just have to wait it out while some of your dose clears your system.

 

[newlosand]

They make a combo Telmisartan-Amlodipine 40 mg/5 mg that would be optimal.

I was up to 80 mg Telmisartan and 5 mg Nebivolol but my systolic BP wouldn't budge under 135. Switched to Telmisartan 40 mg/Amlodipine 5 mg and bam ...120/70ish within a week. Of course individual results may vary...but adding the calcium channel blocker is a huge benefit in combination with the ARB.

Just watch out for hyperkalemia and increasing Creat (mild increases are pretty normal but definitely check blood work within 1 month if you start these).

If you're locked in to the current meds, agree with bumping the Olmesartan but I don't have direct experience with that particular ARB.

 

[OilCarrier]

They make a combo Telmisartan-Amlodipine 40 mg/5 mg that would be optimal.

I was up to 80 mg Telmisartan and 5 mg Nebivolol but my systolic BP wouldn't budge under 135. Switched to Telmisartan 40 mg/Amlodipine 5 mg and bam ...120/70ish within a week. Of course individual results may vary...but adding the calcium channel blocker is a huge benefit in combination with the ARB.

Just watch out for hyperkalemia and increasing Creat (mild increases are pretty normal but definitely check blood work within 1 month if you start these).

If you're locked in to the current meds, agree with bumping the Olmesartan but I don't have direct experience with that particular ARB.

I feel taking amlo is not optimal, seeing the context of this conversation.

 

[newguy2]

I am running my first cycle, 500mg test. BP has been fine I am 11 weeks in. Wednesday I did 50mg shot of Deca. Having some joint issues and going to start at 50mg a week to see if it helps.

Did my BP a few days later and it is very high. This morning was 147/80

Previously was 120-130/60~

Not sure what to do. I do not have nor have I taken BP meds before. I would probably sooner drop the deca than get on them. Any advice?

Update on this, sent my doc a message about it and got a video appointment same day. He got me a script for 40mg telmisartin. Should have it in a couple days. He made me get some labs first to check my kidney function. Thankfully not running any oils.

 

[JakkieJoopie]

Sent you a DM

Howdy! Lurker here but would appreciate a chat about Imelin. Couldn't send a DM (prolly cause I'm new). Shoot me one if you can! Thanks.

 

[BamaCrazy]

Howdy! Lurker here but would appreciate a chat about Imelin. Couldn't send a DM (prolly cause I'm new). Shoot me one if you can! Thanks.

I tried. I cannot DM you either. You should only have to post a few times to gain privileges. Or go to the New Member intro area and donate $10 to the forum. That will get you privileges immediately

 

[Nixonnow99]

Enjoyed reading this thread. Lots of good info.
I'm switching from 50mg Losartan Potassium & 5mg Bisoprolol to 40mg Telmisartan & 5mg Nebivolol
due to Losartan not lasting a full 24 hours and the "widowmaker spikes" in BP associated with it. For that reason alone i don't understand why anyone would be prescribed Losartan.

 

[Ghoul]

Enjoyed reading this thread. Lots of good info.
I'm switching from 50mg Losartan Potassium & 5mg Bisoprolol to 40mg Telmisartan & 5mg Nebivolol
due to Losartan not lasting a full 24 hours and the "widowmaker spikes" in BP associated with it. For that reason alone i don't understand why anyone would be prescribed Losartan.

Because Losartan has been proven to slow diabetes related kidney disease from progressing. It's likely Telm is as good, but docs have to justify their choices, and in the case of diabetics with kidney disease, they have proof for Losartan.

Also, in my experience, for BP and Cholesterol meds. primary care docs have their favorites. They're familiar with them, and rather than update as time goes on, they stick to what they're familiar with as the default, only using something else when they have to.

 

[Mastedon]

It can easily remain good for 7+ years kept refrigerated.

Thank you! I'm going to put my Cilnidipine in the fridge.
How about Ciln+Telm or Telm alone? Pitavastain in the fridge too?
Those are the ones I'm most heavily stocked up on. Any insight is appreciated!

 

[Banana Joe]

I’ve been taking Jardiance.
....
Another drug that I think might be a benefit is Imeglimin. It’s like Metformin, but much better. It not only causes significant reductions in blood glucose, but it can lower HbA1c, AST, and ALT.

Jardiance doesn't seem that useful to me, I dread peeing out the precious carbs I had forced myself to eat!

But this Imeglimin got me curious. Not available in EU, but the Indians sell it really cheap.
Will have to look at it more in depth. Do you think it could replace my 1500mg of Metformin ed?

 

[BamaCrazy]

Jardiance doesn't seem that useful to me, I dread peeing out the precious carbs I had forced myself to eat!

But this Imeglimin got me curious. Not available in EU, but the Indians sell it really cheap.
Will have to look at it more in depth. Do you think it could replace my 1500mg of Metformin ed?

I’ve looked at a few Metformin vs Imeglimin comparisons and I do believe it can replace Metformin. Imeglimin appears to have a better safety profile and head to head Imeglimin outperforms Metformin. Plus there are the additional benefits such as AST/ALT improvements and the possibility of increased quad extension strength the one study found. I’m taking 1000mg Metformin myself and I plan to switch it I can ever get Imeglimin delivered. It’s been seized twice already.

Differential effects of imeglimin and metformin on insulin and incretin secretion—An exploratory randomized controlled trial - PMC

Imeglimin is a new oral anti‐diabetic drug with a similar structure to that of metformin; however, unlike metformin, clinical trials indicate that imeglimin elicits its glucose‐lowering effect mainly by enhancement of insulin secretion. The ...

pmc.ncbi.nlm.nih.gov

“The reduction in HbA1c at 24 weeks was similar in IME and MET. OGTT revealed a comparable decrease in post‐challenge blood glucose excursion in both groups, but insulin levels were increased only in IME. Total and active glucagon‐like peptide‐1 (GLP‐1) levels were increased in both IME and MET; however, total and active glucose‐dependent insulinotropic peptide (GIP) levels were increased only in IME. Interestingly, while an increase in insulin levels in IME was positively correlated with an increase in GLP‐1 at 12 weeks, it was correlated only with an increase in GIP at 24 weeks.”

 

[Banana Joe]

I’ve looked at a few Metformin vs Imeglimin comparisons and I do believe it can replace Metformin. ...

Thanks, will look into that!

On another note - I have 155 LDL and my BP is in the 130/80 range. I plan to get on Pitavastatin Ezemtibe.

Would I gain much if anything from taking 20-40mg of Telmisartan? I guess a guy my age and weight will only profit, as my BP will surely not get too low, but I am hesitant to drug just for the sake of adding a drug....

 

[BamaCrazy]

Thanks, will look into that!

On another note - I have 155 LDL and my BP is in the 130/80 range. I plan to get on Pitavastatin Ezemtibe.

Would I gain much if anything from taking 20-40mg of Telmisartan? I guess a guy my age and weight will only profit, as my BP will surely not get too low, but I am hesitant to drug just for the sake of adding a drug....

Personally I would not be comfortable with a systolic of 130. I believe 20mg Telmisartan will get you down below 120 within a couple of weeks. Some of the things I like about Telmisartan is I never feel any side effects and it has a 24 hour half life. So I am covered around the clock. Which is crucial for morning hypertension. Heart attacks are more common in the morning within the first few hours of waking.

 

[Banana Joe]

Personally I would not be comfortable with a systolic of 130. I believe 20mg Telmisartan will get you down below 120 within a couple of weeks. Some of the things I like about Telmisartan is I never feel any side effects and it has a 24 hour half life. So I am covered around the clock. Which is crucial for morning hypertension. Heart attacks are more common in the morning within the first few hours of waking.

Thanks, I guess I should look further into it then.
When do you take it then? Morning or evening?

What about Nebivolol, it seems like the same kind of drug, that should be able to do very little harm, but a lot of good, even at low doses.
I don't want to loose any my endurance, as my training currently (injuries...) is a hybrid one at best, so I do a lot of LISS cardio of all sorts, complimenting m weak ass strength training.

TIA!

 

[Ghoul]

Thanks, I guess I should look further into it then.
When do you take it then? Morning or evening?

What about Nebivolol, it seems like the same kind of drug, that should be able to do very little harm, but a lot of good, even at low doses.
I don't want to loose any my endurance, as my training currently (injuries...) is a hybrid one at best, so I do a lot of LISS cardio of all sorts, complimenting m weak ass strength training.

TIA!

Excuse the interruption, there are important Telm side effects you should be aware of:

"Telmisartan is unique among blood-pressure medications because it not only blocks angiotensin II (the hormone that tightens blood vessels) but also acts as a partial PPAR-γ agonist, the same cellular receptor targeted by some insulin-sensitizing drugs (and GW-50516 aka Carderine, but without the cancer). Through this mild activation of PPAR-γ, telmisartan improves how the body handles glucose and lipids: it enhances insulin sensitivity, lowers triglycerides, and can raise HDL cholesterol. It also shows some activity on PPAR-δ, which supports mitochondrial energy metabolism and fatty-acid oxidation, helping cells burn fuel more efficiently. These metabolic effects translate into better control of blood sugar, less inflammation in adipose tissue, and a lower risk of developing type 2 diabetes.

At the vascular level, telmisartan improves endothelial function, increases nitric-oxide availability, and reduces oxidative stress, all of which make arteries more elastic and less prone to plaque buildup. It has strong anti-inflammatory and anti-fibrotic actions, dampening cytokines like TNF-α and TGF-β that drive tissue scarring in the heart, kidneys, and liver. Because it crosses the blood-brain barrier, telmisartan also appears to reduce neuroinflammation and support healthy cerebral blood flow, which may contribute to cognitive resilience with aging.

Taken together, these pleiotropic effects mean telmisartan doesn’t just manage blood pressure, it also supports metabolic health, vascular integrity, organ protection, and mitochondrial efficiency through a combination of angiotensin blockade and PPAR-mediated cellular regulation."

PS: Take it whenever it's convenient. All that matters is that you take it consistently, at roughly the same time every day. A pill organizer can help keep everything straight (ie, "Did I already take it today??"). It takes a couple of months for the full benefit to manifest.

 

[BamaCrazy]

Excuse the interruption, there are important Telm side effects you should be aware of:

"Telmisartan is unique among blood-pressure medications because it not only blocks angiotensin II (the hormone that tightens blood vessels) but also acts as a partial PPAR-γ agonist, the same cellular receptor targeted by some insulin-sensitizing drugs (and GW-50516 aka Carderine, but without the cancer). Through this mild activation of PPAR-γ, telmisartan improves how the body handles glucose and lipids: it enhances insulin sensitivity, lowers triglycerides, and can raise HDL cholesterol. It also shows some activity on PPAR-δ, which supports mitochondrial energy metabolism and fatty-acid oxidation, helping cells burn fuel more efficiently. These metabolic effects translate into better control of blood sugar, less inflammation in adipose tissue, and a lower risk of developing type 2 diabetes.

At the vascular level, telmisartan improves endothelial function, increases nitric-oxide availability, and reduces oxidative stress, all of which make arteries more elastic and less prone to plaque buildup. It has strong anti-inflammatory and anti-fibrotic actions, dampening cytokines like TNF-α and TGF-β that drive tissue scarring in the heart, kidneys, and liver. Because it crosses the blood-brain barrier, telmisartan also appears to reduce neuroinflammation and support healthy cerebral blood flow, which may contribute to cognitive resilience with aging.

Taken together, these pleiotropic effects mean telmisartan doesn’t just manage blood pressure, it also supports metabolic health, vascular integrity, organ protection, and mitochondrial efficiency through a combination of angiotensin blockade and PPAR-mediated cellular regulation."

PS: Take it whenever it's convenient. All that matters is that you take it consistently, at roughly the same time every day. A pill organizer can help keep everything straight (ie, "Did I already take it today??"). It takes a couple of months for the full benefit to manifest.

Stop with all this Telmisartan fear mongering. lol