Anyone on GLP-1's for multiple years?

[ChemBB]

I was RX'ed Mounjaro 2 years ago, and have been using various GLP-1's ever since.

tl;dr, at least in terms of appetite, they are doing fuckall for me now
I'm up to 10mg Reta + 3mg Sema and still so hungry, not losing weight anymore.

At this point I'm considering just pinning a vial of Reta E3D, may as well be sugar water...

Anyone else dealt with/overcome this?

 

[NotHuman]

I have been on Retatrutide for nearly eleven months now. I still get appetite suppression on 3mg per week (1mg MWF). RHR is still elevated and never returned to baseline. I have no plans to ever come off. I’m in it for the health benefits.

 

[ChemBB]

Damn, must be unlucky genetics on my end I guess

Thanks for the reply

 

[Ghoul]

I was RX'ed Mounjaro 2 years ago, and have been using various GLP-1's ever since.

tl;dr, at least in terms of appetite, they are doing fuckall for me now
I'm up to 10mg Reta + 3mg Sema and still so hungry, not losing weight anymore.

At this point I'm considering just pinning a vial of Reta E3D, may as well be sugar water...

Anyone else dealt with/overcome this?

I have.

They're not supposed to induce endless weight loss though.

Your level of GLP sets your body's weight "thermostat", ie, the homeostasis weight your biology wants to maintain. Below that weight mechanisms, physical and psychological drive you to eat. Above it, they discourage you from eating. At it, your appetite will be in line with energy requirements.

So dose is titrated up until goal weight is reached, then the dose or a slightly lower one is used for maintenance. You don't feel anything at the maintenance dose, unless you somehow manage to gain weight, then appetite suppression effects return, until you're back at the homeostasis weight.

Are you at the maximum dose but haven't reached goal weight?

 

[ChemBB]

Are you at the maximum dose but haven't reached goal weight?

I'm 5'6, ~195lbs (190 without GH)

Need to get to ~180lbs to compete in Classic Physique, planning on competing first time in 6 months.

Current dose is ~10mg Reta + 3mg Sema/week
(5mg + 1.5mg x2 weekly)

It may be that I just don't respond well to Reta?
I had pretty good results with 10mg Tirz + 2mg Sema previously

 

[adrenalytic]

Try a sensitivity break. Usually takes 5-6 half lives to reset receptor sensitivity. For reta that would be 36 days off.

 

[explodingHeart]

I'm 5'6, ~195lbs (190 without GH)

Need to get to ~180lbs to compete in Classic Physique, planning on competing first time in 6 months.

Current dose is ~10mg Reta + 3mg Sema/week
(5mg + 1.5mg x2 weekly)

It may be that I just don't respond well to Reta?
I had pretty good results with 10mg Tirz + 2mg Sema previously

Try up to 10mg chinese sema? I got damn close to shredded glutes on my shitty TRT+ 250mg + 10mg weekly chinese filtered sema. Wasn't even hungry at that level.

Not a bodybuilder just some 40 year old guy.

 

[Ghoul]

I'm 5'6, ~195lbs (190 without GH)

Need to get to ~180lbs to compete in Classic Physique, planning on competing first time in 6 months.

Current dose is ~10mg Reta + 3mg Sema/week
(5mg + 1.5mg x2 weekly)

It may be that I just don't respond well to Reta?
I had pretty good results with 10mg Tirz + 2mg Sema previously

For many Reta is just weak at appetite suppression. I would definately go back to what you were using before. Or just straight 15mg Tirz, after 2 two weeks on Tirz so it reaches the bulk of its effects add Sema if necessary.

 

[The Answ3r]

Been riding with Tirz for over a year now, started low, pushed up to 15 mg, and now chilling at 10 mg. Never once had those crazy hunger attacks, even tried to outsmart it once and overeat for fun, but the next day Tirz made sure I paid the price. Got two weeks left before I switch to Reta just to see what’s up. I still love Tirz, it’s been solid, but sometimes you just wanna mix things up like trying a new gym, even though you know your old one still gives you the best pump.

 

[Deadpool99]

For many Reta is just weak at appetite suppression. I would definately go back to what you were using before. Or just straight 15mg Tirz, after 2 two weeks on Tirz so it reaches the bulk of its effects add Sema if necessary.

My biggest mistake was probably using reta then stocking up for 4-5months of it. It was my first glp1 and didn't want to have smth aggressive. Tirz probably would have killed my appetite even more and possibly better insulin sensitivity,

On a bulk 15mg reta is great, but when cutting I had to add 1mg cagri, now upto 1.5mg. I heard some fuss about desensitization on cagri but hopefully I probably won't reach the 4-5mg max dose. Need to use for 2-3 weeks before I bulk again.

I was also interested in Tesofensine for the insane suppression and tdee boost and mild stimulant/thermogenic.

But holy shit the sides I discovered, The potential psychiatric effects, hypertension, possible CNS disturbances also causing insomnia (that's assuming ur okay with the GI sides). Also no long term studies as well as the possible drug interactions and tolerance buildup.

 

[Zc7219]

My biggest mistake was probably using reta then stocking up for 4-5months of it. It was my first glp1 and didn't want to have smth aggressive. Tirz probably would have killed my appetite even more and possibly better insulin sensitivity,

On a bulk 15mg reta is great, but when cutting I had to add 1mg cagri, now upto 1.5mg. I heard some fuss about desensitization on cagri but hopefully I probably won't reach the 4-5mg max dose. Need to use for 2-3 weeks before I bulk again.

I was also interested in Tesofensine for the insane suppression and tdee boost and mild stimulant/thermogenic.

But holy shit the sides I discovered, The potential psychiatric effects, hypertension, possible CNS disturbances also causing insomnia (that's assuming ur okay with the GI sides). Also no long term studies as well as the possible drug interactions and tolerance buildup.

Using retard doses and complaining about sides lol.

 

[Deadpool99]

Using retard doses and complaining about sides lol.

Wait I complained about sides? "raised eyebrow emoji"

btw the tesofensine sides, that was research based, never tried it.

 

[Zc7219]

Wait I complained about sides? "raised eyebrow emoji"

btw the tesofensine sides, that was research based, never tried it.

I read the final paragraph as your sides for the 15mg of Reta not teso. My bad. That’s still an insane amount of Reta, and gear, and fat burners for your height and weight man.

 

[Deadpool99]

I read the final paragraph as your sides for the 15mg of Reta not teso. My bad. That’s still an insane amount of Reta, and gear, and fat burners for your height and weight man.

The intrusive thoughts win, thankfully all labs and check ups have proven no measurable damage yet. The fat burners stop in 2 weeks and probably won't touch them again. Maybe low dose clen like 80-120mcg but that's it. T3 was fun to use, especially since I rly overestimated my BF and made this cut not take too long.

 

[Deadpool99]

The intrusive thoughts win, thankfully all labs and check ups have proven no measurable damage yet. The fat burners stop in 2 weeks and probably won't touch them again. Maybe low dose clen like 80-120mcg but that's it. T3 was fun to use, especially since I rly overestimated my BF and made this cut not take too long.

But reta is being used for non fat burning purposes.

I have always managed to eat alot, even when I'm full I can eat past the fullness and bloating. Which got me obese for years, I would eat takeout 4 times and still manage to continue to eat. I can eat 2 main dishes at cheesecake factory and the nachos alone, then finish the leftovers of the family ( family gathering of 7). Then eat dessert. Heaviest I weighed was 310lbs.

Turns out my self-control are determination were elite but I never knew that. When I was obese I trained in the gym for 2 years. Then got fed up, did a water fast, 6 day water fast, 1 day maintenance refeed. Was natty, didn't know what a glp1 was and was 17 years old. Reached 150lbs in 4-5 months. It was dumb ofc, but I never regret it, it's what gave me life and motivation and hope that I won't be ugly forever.

Now I am on 15mg reta, even on a bulk, eating high volume clean foods. As you see the hunger hasn't left, but idc for cravings even on a bulk. Always eat clean.

Reta gave me the opportunity to actually put the fork down and say I'm full, never happened in my entire existence. I use it not for weight loss and BG (though it helps). It actually makes me eat food without the fear of not being full.

 

[keengkong]

I was RX'ed Mounjaro 2 years ago, and have been using various GLP-1's ever since.

tl;dr, at least in terms of appetite, they are doing fuckall for me now
I'm up to 10mg Reta + 3mg Sema and still so hungry, not losing weight anymore.

At this point I'm considering just pinning a vial of Reta E3D, may as well be sugar water...

Anyone else dealt with/overcome this?

If you have already lost a large amount of weight, it could be that you're no longer losing weight but the medicine is still working. The medicine is working because you're not regaining the weight.

 

[psauce]

What else are you running? If there's an appetite stimulator in the mix, it might be easier to replace that than hammering more suppressors.

 

[ChemBB]

Got two weeks left before I switch to Reta just to see what’s up. I still love Tirz, it’s been solid, but sometimes you just wanna mix things up like trying a new gym, even though you know your old one still gives you the best pump.

Good luck, hopefully it works for you! It's my least favorite/effective GLP-1 I've used.

I'd rate them Tirz > Sema > Reta
But that's personal experience, most people seem to love Reta

You can buy like x3-4 as much Sema for Tirz with the same money so I tended to just stock up on that. Probably should have invested more in Tirz in retrospect.

I was also interested in Tesofensine for the insane suppression and tdee boost and mild stimulant/thermogenic.

I picked up a bottle of 100 x 0.5mg, didn't look a ton into it before buying because it was so cheap.

It definitely works, but I've only used it a few times because it's a volatile drug. Tried 0.5mg and 0.25mg, the 0.25mg was a much better experience.

Probably not going to end up using it. Stims to cut, like Adderall or Phentermine, is never sustainable and tends to ruin you mentally.

The medicine is working because you're not regaining the weight.

Fair enough

What else are you running?

Just 300 Test, 4iu GH, and Cialis + Cardarine

 

[Deadpool99]

Good luck, hopefully it works for you! It's my least favorite/effective GLP-1 I've used.

I'd rate them Tirz > Sema > Reta
But that's personal experience, most people seem to love Reta

You can buy like x3-4 as much Sema for Tirz with the same money so I tended to just stock up on that. Probably should have invested more in Tirz in retrospect.


I picked up a bottle of 100 x 0.5mg, didn't look a ton into it before buying because it was so cheap.

It definitely works, but I've only used it a few times because it's a volatile drug. Tried 0.5mg and 0.25mg, the 0.25mg was a much better experience.

Probably not going to end up using it. Stims to cut, like Adderall or Phentermine, is never sustainable and tends to ruin you mentally.

Fair enough

Just 300 Test, 4iu GH, and Cialis + Cardarine

Try Cagri, for someone who reached 15mg reta and eats clean volume foods while stacking a shit ton of fiber into my drinks/ninja creamis (glucomannan/physiullum husk/Fibersol-2) and still get’s hungry. Cagri does a good job.

Those ninja creami pints are as satiating as a family gathering dinner, ppl who try it can’t finish it in an empty stomach. For me it’s an appetizer.

If you’re like me and get used to drugs fairly quickly or tolerate them well. Cagri hits a different hormone receptor, so it’ll def help u, atleast short term. It’s helping me push past the last few weeks of my cut.

 

[ChemBB]

If you’re like me and get used to drugs fairly quickly or tolerate them well. Cagri hits a different hormone receptor, so it’ll def help u, atleast short term. It’s helping me push past the last few weeks of my cut.

Sounds interesting, but damn is it expensive compared to just buying more Sema/Tirz =/