BamaCrazy
Banned
I’m curious about the eplerenone. Is that for someone else?
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bigdaddyandfriends
Member
I don’t know but would assume the UAE packages are cross shipped there from India, which will take days. Then they are reshipped from UAE to USA.
Lots is extra work but seems containers incoming from UAE and packages within of larger size are put through less scrutiny then ones arriving directly from India - which means lower seizure rates and less reships/losses.
Lots is extra work but seems containers incoming from UAE and packages within of larger size are put through less scrutiny then ones arriving directly from India - which means lower seizure rates and less reships/losses.
Deadpool99
Member
Using it to test it out for these reasons:
- Prevents aldosterone-driven LVH and cardiac fibrosis (tren/HGH risk).
- Protects kidneys and heart remodeling long term.
- No sexual side effects (unlike spironolactone).
- Works synergistically with telmisartan + Jardiance for CV protection.
Although one takeaway from all these benefits:
- Risk of high potassium (hyperkalemia), especially combined with telmisartan.
- Needs periodic labs (K⁺, creatinine, eGFR) to stay safe.
In conclusion,
- Eplerenone is one of the few drugs shown to reverse LVH (left ventricular hypertrophy), not just slow it. Multiple trials showed reductions in cardiac fibrosis, improved ejection fraction, and better survival in heart-failure patients.
- In resistant hypertension and metabolic syndrome models, it reduces arterial stiffness and vascular inflammation — both highly relevant to tren/test/HGH use.
So it's a very proven pharmaceutical tool for CV protection and it seems like a no brainer to me based on my research.
Photon
Member
I take this for LVH prevention.
It's FDA approved for resistant hypertension so you might be able to convince your PCP to prescribe it.
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Deadpool99
Member
Bro knows
bigdaddyandfriends
Member
Interesting drug. It’s sort of like a selective spironolactone, without the anti-androgen effect (which is really insignificant for men using TRT/gear).
Many of us here are probably using telmisartan (or another ARB) and/or Nebivolol… so caution is needed. I think chlorthalidone or indapamide might be a better choice - and certainly they are way cheaper, plus available as convenient/inexpensive combo pills. They won’t be hailed as some miraculous drug that can reverse/prevent LVH but they likely have a very similar effect… except they’ll help to decease rather than increase potassium levels.
Unfortunately the first sign of hyperkalemia can be asystole, so monitor K+ levels carefully when adding this drug to an ARB/BB. I use potassium citrate ER (for kidney stone prophylaxis) and my serum K+ got pretty high on just azilsartan and a little higher when I added Nebivolol.
Now K+ is good and BP great even with Urocit-K on Telmiheal Trio… going to order a bunch more now that PCT24x7 is back.
Many of us here are probably using telmisartan (or another ARB) and/or Nebivolol… so caution is needed. I think chlorthalidone or indapamide might be a better choice - and certainly they are way cheaper, plus available as convenient/inexpensive combo pills. They won’t be hailed as some miraculous drug that can reverse/prevent LVH but they likely have a very similar effect… except they’ll help to decease rather than increase potassium levels.
Unfortunately the first sign of hyperkalemia can be asystole, so monitor K+ levels carefully when adding this drug to an ARB/BB. I use potassium citrate ER (for kidney stone prophylaxis) and my serum K+ got pretty high on just azilsartan and a little higher when I added Nebivolol.
Now K+ is good and BP great even with Urocit-K on Telmiheal Trio… going to order a bunch more now that PCT24x7 is back.
Jeffholio5
Member
How does entresto compare so some of these drugs for lvh function?
Photon
Member
I saw minimal increase in K with ephlerone 50mg 1x a day. Telm 40mg however increased my K by quite abit.
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bigdaddyandfriends
Member
D
That’s what I get, generic Urocit-K (BioComp Pharma).
Also got USA pharma indapamide, I actually like chlorthalidone better but smallest tab in USA is 25mg which is a lot. And it’s long acting too.
That’s what I get, generic Urocit-K (BioComp Pharma).
Also got USA pharma indapamide, I actually like chlorthalidone better but smallest tab in USA is 25mg which is a lot. And it’s long acting too.
Do you guys that take something like Telmisartan still supplement with potassium?
I started doing some nosalt as I don't get much potassium, but recently introduced Telmisartan because of high BP and was warned about potassium.
I drink a lot of water and use a decent amount of mineral salt on my food. So felt like my electrolytes could be off but now not sure if I should add any potassium.
I started doing some nosalt as I don't get much potassium, but recently introduced Telmisartan because of high BP and was warned about potassium.
I drink a lot of water and use a decent amount of mineral salt on my food. So felt like my electrolytes could be off but now not sure if I should add any potassium.
Photon
Member
Yea i made the mistake of assuming you were getting it from India, lol. Only realized that after posting my reply and quickly edited my post. How do you measure it's effectiveness? uric acid? urine pH?
I'm on reta which seems to result in low uric acid (constantly below baseline), but my urine is usually acidic (makes me wonder if i should add some potassium to it)
bigdaddyandfriends
Member
it’s not the potassium, it’s the citrate. It alkalinizes the urine which keeps helps keep uric acid from crystallizing out. You may or may not know, but essentially all kidney stones regardless of composition (and most are calcium oxalate) are built around a uric acid core. So if you keep the uric acid in solution, other crystals won’t pile on and form a stone.
I used to take (2) 15 mEq potassium citrate per day but had to cut back to one when I started an ARB. I replaced the missing one with magnesium citrate which is OTC but no extended release so needs to be taken frequently, and too much will make you poop. Going to try reverting back to 2 K-cit per day as I dumped Nebivolol for cilnidipine (neutral for K+, and way more effective) and added a low dose potassium losing diuretic too when I upped some dosages.
I used to take (2) 15 mEq potassium citrate per day but had to cut back to one when I started an ARB. I replaced the missing one with magnesium citrate which is OTC but no extended release so needs to be taken frequently, and too much will make you poop. Going to try reverting back to 2 K-cit per day as I dumped Nebivolol for cilnidipine (neutral for K+, and way more effective) and added a low dose potassium losing diuretic too when I upped some dosages.
Dumbellsanonymous
Member
Looks like I'm adding this to my order lol thanks for the info!
Dumbellsanonymous
Member
What do you suggest for Lvh currently using 80mg telmisarten so wanna be careful as you mentioned above. Running eq as why I'm on 80 mg and keeps my bp in healthy range tried 40mg my bp was still a little high for my liking.
Thanks in advance
I don't know the details of getting items into the US. I don't actually want to know the details. It's kind of like making sausage - I don't want to know the process. I just like the results.
bigdaddyandfriends
Member
Logistics, customs, “warehouses” … yes it’s kind of like how sausage is made.
I appreciate everything that goes into producing it whether good UGL or pharma, selling it, and getting it into my mailbox
I appreciate everything that goes into producing it whether good UGL or pharma, selling it, and getting it into my mailbox
BamaCrazy
Banned
My potassium levels are good on 20mg Telmisartan. But get out of range fast on 40mg. I make my own electrolytes drink with sodium citrate and magnesium citrate from Bulk Supplements so I can avoid potassium. I also try and minimize potassium intake from my diet.
Oh wow so without even taking anything it gets high. Ok good to know that's helpful.
BamaCrazy
Banned
I’m an outlier. In the last 12-18 months I think I’ve encountered one person that has the same issue. Dozens of members here take 40-80mg a day with no issues.
Thanks. I need to get electrolytes sorted as I drink a ton of water and don't take anything. But adding in telmi through me off a bit with the potassium thing.
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