Homebrew Depo-Provera

[OffendHand]

I'm trying to do some homebrew depo-Provera. When I look at the label of the box, it says that each mL has 400mg of medroxyprogesterone acetate, 20.3mg PEG 3350, 11mg sodium sulfate anhydrous, and 1.69mg myristyl-gamma-picolineum as a preservative. The directions call for it to be vigorously shaken prior to use.

So, first, I assume that this is a suspension in bacteriostatic water. Is this correct? The concentration of benzyl alcohol in distilled water is supposed to be .9-1.1%. Is bacteriostatic water made by sterilising the water first, and then adding the benzyl alcohol? Or are they mixed and then filtered with a .22um (or smaller) filter?

Otherwise, are there any good sources for bac water in the US? I haven't used suspensions before, so I've never needed it.

Oncei have everything mixed at the correct proportions, should I just follow the directions for making any other suspensions, like stanozolol?

 

[IndividualMan]

BAc water is not just distilled water + BA, it is STERILE WATER FOR INJECTION + BA. important distinction

 

[Photon]

I'm trying to do some homebrew depo-Provera. When I look at the label of the box, it says that each mL has 400mg of medroxyprogesterone acetate, 20.3mg PEG 3350, 11mg sodium sulfate anhydrous, and 1.69mg myristyl-gamma-picolineum as a preservative. The directions call for it to be vigorously shaken prior to use.

So, first, I assume that this is a suspension in bacteriostatic water. Is this correct? The concentration of benzyl alcohol in distilled water is supposed to be .9-1.1%. Is bacteriostatic water made by sterilising the water first, and then adding the benzyl alcohol? Or are they mixed and then filtered with a .22um (or smaller) filter?

Otherwise, are there any good sources for bac water in the US? I haven't used suspensions before, so I've never needed it.

Oncei have everything mixed at the correct proportions, should I just follow the directions for making any other suspensions, like stanozolol?

It's a suspension in PEG3350.
Why not just use oil?
it dissolves in oil.

 

[OffendHand]

BAc water is not just distilled water + BA, it is STERILE WATER FOR INJECTION + BA. important distinction

Yes, I'm aware. That's why I'm asking about sterilisation specifically, and the proper order to go in. I assume that I want to sterilise it by filtration--i could autoclave it, but that should affect the concentration of the BA--but I'm not sure.

...Although filtering after mixing the suspension should also be sterilizing the solution.

 

[OffendHand]

It's a suspension in PEG3350.
Why not just use oil?
it dissolves in oil.

PEG 3350 is a solid, and can be hydrated to a liquid.

And I don't know if there's a good reason to not use oil or not, TBH. That would be easier. But I don't know why the branded version uses PEG, et al.

 

[IndividualMan]

Yes, I'm aware. That's why I'm asking about sterilisation specifically, and the proper order to go in. I assume that I want to sterilise it by filtration--i could autoclave it, but that should affect the concentration of the BA--but I'm not sure.

...Although filtering after mixing the suspension should also be sterilizing the solution.

buy the sterile water for injection. its like 2 bucks for 100 ml

 

[Photon]

PEG 3350 is a solid, and can be hydrated to a liquid.

And I don't know if there's a good reason to not use oil or not, TBH. That would be easier. But I don't know why the branded version uses PEG, et al.

Suspension
https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/020246s058lbl.pdf

Sesame oil
https://www.accessdata.fda.gov/drugsatfda_docs/label/2007/017362s104lbl.pdf
But i would not use 10% BA tho..I'd rather use BA/BB.

 

[sionnach]

I'm trying to do some homebrew depo-Provera.

*orders primo*
*India sends depoprovera*
"Fuck it"
*improvises*

LMAO. I like your style, bruh.

 

[dinfar1337]

Is bacteriostatic water made by sterilising the water first, and then adding the benzyl alcohol

yes, you can just boil the distilled water and then filter it, then add your benzyl alcohol.

although its not as perfect as hospira bac were they make the water through some big million machine with h2 and o to be perfectly sterile. it should be good enough!

 

[OffendHand]

yes, you can just boil the distilled water and then filter it, then add your benzyl alcohol.

although its not as perfect as hospira bac were they make the water through some big million machine with h2 and o to be perfectly sterile. it should be good enough!

I would probably run my distilled water through a steam autoclave for an hour or so; that would definitely, absolutely sterilise the water.

 

[OffendHand]

*orders primo*
*India sends depoprovera*
"Fuck it"
*improvises*

LMAO. I like your style, bruh.

It's actually for managing HRT for someone else because their doctor... Won't. I'm also getting estradiol cypionate; both are necessary for HRT.

Annoyingly, MOQ on both is 100g; if a transwomen was on the maximum dose--10mg EW--that's about 192 *years*. For cis-gender women doing HRT, doses are more like 2-5mg EW. Oh well.

 

[dinfar1337]

I would probably run my distilled water through a steam autoclave for an hour or so; that would definitely, absolutely sterilise the water.

should be good enough! sorry i cant help further but i think you should follow photons advice for manageable shelf life

 

[Superchicken]

It's actually for managing HRT for someone else because their doctor... Won't. I'm also getting estradiol cypionate; both are necessary for HRT.

Annoyingly, MOQ on both is 100g; if a transwomen was on the maximum dose--10mg EW--that's about 192 *years*. For cis-gender women doing HRT, doses are more like 2-5mg EW. Oh well.

I’m not sure if you or the person you’re helping with hrt is aware, but depo is one of the synthetic progestins that was associated with negative outcomes in the original WHI study. Bioidentical is the standard first line of treatment, moving onto progestins if necessary. Bio also offers the most therapeutic benefits for support. India pharm is the only place I’ve seen it offered in 100 and 200mg ampoules. It’s what I used while I waited on an appt to switch from oral progesterone to injections. The only downside is the progesterone injx need to be done more frequently.

 

[IndividualMan]

I’m not sure if you or the person you’re helping with hrt is aware, but depo is one of the synthetic progestins that was associated with negative outcomes in the original WHI study. Bioidentical is the standard first line of treatment, moving onto progestins if necessary. Bio also offers the most therapeutic benefits for support. India pharm is the only place I’ve seen it offered in 100 and 200mg ampoules. It’s what I used while I waited on an appt to switch from oral progesterone to injections. The only downside is the progesterone injx need to be done more frequently.

i second this, try to go for bioidentical prog.

It's actually for managing HRT for someone else because their doctor... Won't. I'm also getting estradiol cypionate; both are necessary for HRT.

Annoyingly, MOQ on both is 100g; if a transwomen was on the maximum dose--10mg EW--that's about 192 *years*. For cis-gender women doing HRT, doses are more like 2-5mg EW. Oh well.

always go for bioidenticals. having extra stock is never a bed thing.

 

[OffendHand]

I’m not sure if you or the person you’re helping with hrt is aware, but depo is one of the synthetic progestins that was associated with negative outcomes in the original WHI study. Bioidentical is the standard first line of treatment, moving onto progestins if necessary. Bio also offers the most therapeutic benefits for support. India pharm is the only place I’ve seen it offered in 100 and 200mg ampoules. It’s what I used while I waited on an appt to switch from oral progesterone to injections. The only downside is the progesterone injx need to be done more frequently.

Do you have a link for that?

My understanding was that depo-Provera in low dose--not what's typically used for birth control--was one of the frontline progestogens mostly because it could be done infrequently. (Frontline praise of the US, anyways.) I believe there's a risk of liver damage over the long term with oral versions, and I believe you need to take them either all month or for ten days, depending on how you're dosing.

Honestly, this is mostly because they know I've prepped my own TRT and PEDs for years, and I'm dumb enough to try. So I'm wide open to any guidance. I have guidance on converting disagree from an oral to an injected, but...

 

[Superchicken]

Do you have a link for that?

My understanding was that depo-Provera in low dose--not what's typically used for birth control--was one of the frontline progestogens mostly because it could be done infrequently. (Frontline praise of the US, anyways.) I believe there's a risk of liver damage over the long term with oral versions, and I believe you need to take them either all month or for ten days, depending on how you're dosing.

Honestly, this is mostly because they know I've prepped my own TRT and PEDs for years, and I'm dumb enough to try. So I'm wide open to any guidance. I have guidance on converting disagree from an oral to an injected, but...

I’m not familiar with the dosing of MPA at all as it’s what hormone specialists speak out against, so am not sure about the 10 days v all month. I know there are some women who take prog daily and some who cycle it. I take it daily and always have because skipping causes me to have shitty sleep. The most important thing is to have the proper dose to support the estrogen. As far as liver toxicity, that’s not something I’ve heard of with progesterone, but is slightly increased with oral e.

“Oral E2/P4 was associated with significantly lower VTE risk than oral CEE/MPA”

“Conjugated equine estrogens/medroxyprogesterone acetate (CEE/MPA) is associated with increased risk of venous thromboembolism (VTE)”

https://www.maturitas.org/article/S0378-5122(23)00066-X/fulltext

“MP + t-E2 demonstrated a positive effect on traditional CVD markers, with a significant improvement seen in cardiac output”

https://www.maturitas.org/article/S0378-5122(22)00025-1/abstract

This last one discusses the risk/benefit profiles btwn progesterone and MPA.

https://www.maturitas.org/article/S0378-5122(15)00314-X/fulltext

This is a quick write up from a dr discussing the differences.

Progesterone or Progestin? Understanding the Confusion in Women’s Hormone Therapy

Confused about progesterone vs. progestins? Learn the differences between natural progesterone and synthetic drugs like medroxyprogesterone.

drannagarrett.com

View: https://www.instagram.com/reel/DFwBo2ASM1e/?igsh=eW4zZ3pubDBjYjcy


Dr Kelly Casperson is a urologist and hormone specialist, same name for her Instagram acct. She also has an extremely informative podcast on women’s health called, You Are Not Broken, and book by the same name. I know she’s talked about progesterone/progestins before. Peter Attia recently did a podcast episode with Dr Rachel Rubin on hrt, might be worth listening to.

Hope some of that helps! I personally started with transdermal estrogen patch with oral progesterone. I switched to twice weekly estrogen injections and still use oral P for sleep, but now in addition to injections.

 

[Spaceman Spiff]

Wtf is wrong with you?


You don't need to be brewing this shit.

It's a long acting birth control and you are going to be fucking with people.

You don't seem like you even know how to fucking brew

 

[OffendHand]

Wtf is wrong with you?


You don't need to be brewing this shit.

It's a long acting birth control and you are going to be fucking with people.

You don't seem like you even know how to fucking brew

Medroxyprogesterone acetate has been used extensively for HRT in combination with estradiol, although it is usually 2.5-5mg orally.

Progestogens Used in Postmenopausal Hormone Therapy: Differences in Their Pharmacological Properties, Intracellular Actions, and Clinical Effects - PMC

The safety of progestogens as a class has come under increased scrutiny after the publication of data from the Women's Health Initiative trial, particularly with respect to breast cancer and cardiovascular disease risk, despite the fact that only ...

pmc.ncbi.nlm.nih.gov

The increased risk of breast cancers associated with medroxyprogesterone acetate for HRT is fairly low; the increased annualised risk is .09% higher with medroxyprogesterone acetate (https://jamanetwork.com/journals/jama/fullarticle/2768806), with no increase in mortality associated.

Also, dude. I've been brewing my own for over a decade. I haven't done suspensions before, because I had no use for them. I've stuck with brewing test e/c, deca, EQ, tren c, and capping superdrol, anadrol, d-bol, and var, because those were what I used. (Plus adex and DNP, but they aren't AAS.)

 

[Spaceman Spiff]

I would probably run my distilled water through a steam autoclave for an hour or so; that would definitely, absolutely sterilise the water.

Also, dude. I've been brewing my own for over a decade

You don't seem to understand what truly sterilizes it..



But ok. Go at it

 

[IndividualMan]

Medroxyprogesterone acetate has been used extensively for HRT in combination with estradiol, although it is usually 2.5-5mg orally.

Progestogens Used in Postmenopausal Hormone Therapy: Differences in Their Pharmacological Properties, Intracellular Actions, and Clinical Effects - PMC

The safety of progestogens as a class has come under increased scrutiny after the publication of data from the Women's Health Initiative trial, particularly with respect to breast cancer and cardiovascular disease risk, despite the fact that only ...

pmc.ncbi.nlm.nih.gov

The increased risk of breast cancers associated with medroxyprogesterone acetate for HRT is fairly low; the increased annualised risk is .09% higher with medroxyprogesterone acetate (https://jamanetwork.com/journals/jama/fullarticle/2768806), with no increase in mortality associated.

Also, dude. I've been brewing my own for over a decade. I haven't done suspensions before, because I had no use for them. I've stuck with brewing test e/c, deca, EQ, tren c, and capping superdrol, anadrol, d-bol, and var, because those were what I used. (Plus adex and DNP, but they aren't AAS.)

WHY in gods name would you do a suspension then?
MPA is questionable already, but why make a suspension? Oil is the best carrier, no matter the hormone. DOnt just emulate a brew for the sake of emulating it.
People do not brew Test Undecanoate 250mg/ml @ 50something BB just because Bayer Nebido uses 50% BB. There is no reason to emulate pharma recipes, when you have the option of just going the 2BA20BB Route, and fill the rest with oil.
If this is for a womans HRT or Birth Control, Use oil. If it is for a trans person who uses even more than the HRT/BC woman would, still use oil. It would be foolish not to.
ANd ffs, if the person using it is not a pussy, use regular progesterone, (with an ester if possible, but even ed pins with regular prog would be better if they can handle it)