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Might be in my head too much but i've been using GH for around 2 years maybe, 5iu year round and can confirm my head, nose and forehead have all grown LOL
So dropping to 2-3iu for a 8-12 week cruise would be sufficient for the year?
Is that a big issue when running 4ius year round?
Is that a big issue when running 4ius year round?


great explanation, thanks for the info. Imma test it in a week or 2, I think at 4ius, realistically I'd be around 1.3 - 1.8 at my age (21) but we'll have to see.The way risk is measured is by IGF-1 level for your age, not the dose of rHGH.
Find your ULN (upper limit of normal) IGF based on assay type(ie lab that performed the test):
View attachment 345268
Your risk of developing signs of acromegaly depends on how much higher than the ULN you are:
View attachment 345269
At 1.3x ULN acromegaly features could begin to develop at between 2-5 years if you sustain IGF this high.
At 1.5x initial features can develop at 2 years.
At 2x at 1 year.
Above 2x acromegaly can develop in less than a year,
great explanation, thanks for the info. Imma test it in a week or 2, I think at 4ius, realistically I'd be around 1.3 - 1.8 at my age (21) but we'll have to see.
I'm using lr3 40mcg as well for 6weeks so it'll be interesting to see the results
yep, outside of LVH, organomegaly, increased cancer.You can see on the chart your levels can be much higher, and even when exceeding them, excess IGF can be "absorbed" into normal growth so problems would take much longer to develop at 20 than someone at 50 running 1.5x.
With age the excess IGF becomes increasingly likely to cause abnormal circus freak growth.
yep, outside of LVH, organomegaly, increased cancer.
I always wondered if the main precursor to those bodybuilder's bubble guts were the insane doses of GH or was it also the insulin. I feel like GH would softly contribute to it but insulin would be the final nail in the coffin as you need to eat a shit ton of calories and bloating and igf1 ramp up would likely be the main cause, I think.
Cuz honestly that bubble gut is fucking hideous IMO.

Thanks for taking your time and posting this. This is exactly what I was looking for.The way risk is measured is by IGF-1 level for your age, not the dose of rHGH.
Find your ULN (upper limit of normal) IGF based on assay type(ie lab that performed the test):
View attachment 345268
Your risk of developing signs of acromegaly depends on how much higher than the ULN you are:
View attachment 345269
At 1.3x ULN acromegaly features could begin to develop at between 2-5 years if you sustain IGF this high.
At 1.5x initial features can develop at 2 years.
2x starting at 1 year.
Above 2x acromegaly can begin to develop in less than a year,
First is soft and connective tissue, lips, nose, ears, organs, fully (lips) or partially (cartilage) reversible if you stop in time.
Then bone changes slowly over time, forehead, chin, teeth begin to misalign, irreversible.
It happens so slowly even family members often miss it for 5+ years.
Thanks for taking your time and posting this. This is exactly what I was looking for.
Been hesitant to start , but this a good baseline .
If one were to only run higher HGH for a shorter period of 6mos or less, then drop to a dose that is <1.2 ULN, does that mitigate the risk? Or is there a permanent impact from the higher dose, even if not visible and if you ever resume at a higher dose, you are essentially picking up where you left off in terms of potential side effects?The way risk is measured is by IGF-1 level for your age, not the dose of rHGH.
Find your ULN (upper limit of normal) IGF based on assay type(ie lab that performed the test):
View attachment 345268
Your risk of developing signs of acromegaly depends on how much higher than the ULN you are:
View attachment 345269
At 1.3x ULN acromegaly features could begin to develop at between 2-5 years if you sustain IGF this high.
At 1.5x initial features can develop at 2 years.
2x starting at 1 year.
Above 2x acromegaly can begin to develop in less than a year,
First is soft and connective tissue, lips, nose, ears, organs, fully (lips) or partially (cartilage) reversible if you stop in time.
Then bone changes slowly over time, forehead, chin, teeth begin to misalign, irreversible.
It happens so slowly even family members often miss it for 5+ years.
come on man , this has been exhaustively discussed and if you actually used the search function you're gonna find the answer, but im sure ol Ghoul will chime in.If one were to only run higher HGH for a shorter period of 6mos or less, then drop to a dose that is <1.2 ULN, does that mitigate the risk? Or is there a permanent impact from the higher dose, even if not visible and if you ever resume at a higher dose, you are essentially picking up where you left off in terms of potential side effects?
Why is it that the IGF level necessary to cause those issues varies with age? You’d think if 400 was safe from those side effects at age 22, it would be safe also at age 50.The way risk is measured is by IGF-1 level for your age, not the dose of rHGH.
Find your ULN (upper limit of normal) IGF based on assay type(ie lab that performed the test):
View attachment 345268
Your risk of developing signs of acromegaly depends on how much higher than the ULN you are:
View attachment 345269
At 1.3x ULN acromegaly features could begin to develop at between 2-5 years if you sustain IGF this high.
At 1.5x initial features can develop at 2 years.
2x starting at 1 year.
Above 2x acromegaly can begin to develop in less than a year,
First is soft and connective tissue, lips, nose, ears, organs, fully (lips) or partially (cartilage) reversible if you stop in time.
Then bone changes slowly over time, forehead, chin, teeth begin to misalign, irreversible.
It happens so slowly even family members often miss it for 5+ years.
