explodingHeart
Member
my BP rarely went above 120/80. Can't really control the water.
MESO-Rx
Anabolic Steroids
Qingdao Sigma Chemical Co., Ltd (International, US, EU, Canada and Australia domestic
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When people say Acromegaly, they're usually referring to the skeletal facial changes, which ironically is the slowest danger in acromegaly. Guaranteed 8IUs for 10 yrs will cause organomegaly, diabetes, muscular dysfunction and probably some tumor growth before the jaws start looking funny. .
Ghoul
Member
That and GH increases eGFR filtration rate. So pressure increases inside the kidney.
Here's where I plug Cilnidipine again, which opens up tubules, on both the intake and outflow side, protecting them from being "stretched" under increased pressure, preventing damage.
Ghoul
Member
Also the continuous growth of intestines, which, as a soft tissue, starts pretty fast after high dose GH is initiated. That might even be good for digestive health, but Palumboism sure isn't attractive.
So what is considered a high dose long term or short term?
Ghoul
Member
Short term isn't long enough to really cause excess growth, so high doses for a couple of months, whatever that may be aren't really as much of concern (other than immediate side effects) as what you run for a year+.
You have to monitor IGF-1 to gauge your risk. It's not IUs that determine it.
In general, from the very thin evidence we have, below 1.3x upper limit of normal IGF-1 doesn't cause issues for many years, and may be able to run indefinitely. 2x and above has caused acromegalic features to become initially noticeable in 2 years, and strongly developed by 5. So if you're going above 1.3x upper limit IGF-1 for your age, but below 2x, you might be ok, or you might be on borrowed time depending on how long you stay at that elevated level.
After stopping, bone changes don't reverse. Connective tissue can partially reverse. Soft tissue may fully reverse.
Probably best to take a pic of your face every 3-6 months to monitor for changes. because it's so slow and subtle. People who get pituitary tumors and become acromegalic often have a delayed diagnosis for 5 years or more since they didn't notice their face changing. (often someone else has to point it out).
Well, that's concerning. I already have a tortuous/redundant colon and am so overstuffed I've popped two hernias with two more that were developing. If I add one more goddamn millimeter of intestine I'm gonna pop like one of those prank snakes-in-a-can.
Photon
Member
I'm assuming this isn't an issue with Tesa?
There really isn't much info on healthy patients, but for HIV patients, it does increase igf1 greatly. The average age of this study was 46. So i guess it's still below the upper limit for a normal male (335).
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Ghoul
Member
No known cases of acromegaly from Tesa (though treatment guidelines say stop if IGF exceeds ULN consistently).
Unlike rHGH, Tesa leaves the hypothalamus-pituitary axis feedback loop intact (mostly). So when IGF starts to get too high, GH production is reduced.
In the real world this means for most people on Tesa, IGF maxes out around the upper limit of normal or slightly above, and can't go any higher.
Also, because the Tesa increased release of GH follows the natural pulse pattern, not continuous high levels like rHGH, GH receptors don't downregulate, especially in adipose cells, so the fat loss effects of Tesa is as effective for lipolysis as a high dose of rHGH that would cause very high IGF.
In other words you can lose the same amount of fat with Tesa that would require a dose of rHGH that would put IGF into riskier supra-physiologic ranges.
So a much safer risk profile for long term use if fat lipolysis is your main goal, though lower IGF means growth / recovery isn't as much as rHGH would provide with elevated IGF, albeit with additional risk.
dcfreak
Member
What are your thoughts on running both Tesa and Gh at the same time?
I ask as I purchased kits of Tesamorelin and Ipamorelin to run as an experiment for a few months to see what they did to my IGF-1 levels. (Not a ton)
I have been taking my GH at night and then also taking tesa and ipa together in the am fasted just to use them up but I am wondering with taking the Gh make taking the tesa/ipa pointless?
Ghoul
Member
I don't know how well it would work. I strongly *suspect* since exogenous GH shuts down natural production, there's nothing to "amplify". Like turning up the volume on a stereo that's not playing anything.
What you could use the Tesa for is alternating between rHGH and Tesa every 3-6 months.
My understanding is 3 months of Tesa will maintain the lean mass gains of rHGH, continue lipolysis fat loss, but allow desensitized GH receptors to recover. so when you go back to rHGH, it's significantly more effective.
dcfreak
Member
Appreciate the reply
Don't be scared off, just be conservative. If you are over 50 and your IGF-1 range is say 50-192 and naturally you are say around 65, bumping up (via exogenous use) to 180 should actually make you healthier.
I just reduce my weekly number of injections. 3 iu's e5d was putting me over the top, but 4 days a week puts me right at the top.
OEP LABS
Subscriber
The reason for switching to silicone was for that very reason. Breaking down butyl rubber. Once I made the switch, game over never had an issue. Ever. We are talking about let’s see 5yrs plus now using silicone
I think you posted this in wrong thread.
Ghoul
Member
Right. In this thread we're looking for sterile floaters and inexplicable pip after a few months, not this "5 year shelf life" shit.
sionnach
Banned
Don't forget solving the "mystery" of male/female.
nighthawkmuscle
New Member
Anyone got that list of the numbers?
Got some A058 I’m trying to indentify
for some unknown reason to me, I decided not to label it.
Got some A058 I’m trying to indentify
for some unknown reason to me, I decided not to label it.
Tesamorelin 10mg
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