High dosing SLU PP 332

[GabrielAc]

I’ve seen mixed reports on SLU-PP-332, some people claim great results at around 100mcg, while others say they got zero results at 20mg. Has anyone here tried a dose theoretically scaled for human body weight, something like 100mg+? I even saw an Instagram post where someone claimed 500mg/day with “crazy” results. Let us know what you felt and if you had good results from those dosages

 

[DinoBB76]

250mcg pre fasted cardio
250mcg pre workout
250mcg in the evening

is just a good dose to see a result with metabolism , fat loss without zero change with gear or diet

you can try up to 500mcg , but before take SLU your diet and lifestyle it's need to be perfect

 

[wells14]

some people claim great results at around 100mcg, while others say they got zero results at 20mg.

That's a crazy disparity if true. Surely they received a fake product? No response from a 200x higher dose seems improbable. Unless genetic factors can cause non response.

 

[Ghoul]

That's a crazy disparity if true. Surely they received a fake product? No response from a 200x higher dose seems improbable. Unless genetic factors can cause non response.

Psychosomatic effects aren't bound by reality,

 

[krvuxn]

Make sure to check if the person getting “crazy results” also has a discount code.

 

[Ghoul]

Make sure to check if the person getting “crazy results” also has a discount code.

What's most telling is that not a single pharma company, even the tiny kookie ones that engage in all sorts of long shot compounds. has expressed any interest in "exercise in a pill", which would be the next GLP blockbuster class of meds. That tells me it's been looked into and dismissed.

 

[GabrielAc]

250mcg pre fasted cardio
250mcg pre workout
250mcg in the evening

is just a good dose to see a result with metabolism , fat loss without zero change with gear or diet

you can try up to 500mcg , but before take SLU your diet and lifestyle it's need to be perfect

Were you counting calories when you tried that?

That's a crazy disparity if true. Surely they received a fake product? No response from a 200x higher dose seems improbable. Unless genetic factors can cause non response.

Yes, that's what I felt. Maybe bunk stuff or placebo from low dosage people.

Make sure to check if the person getting “crazy results” also has a discount code.

I was either placebo or that but saw some people here also talking about results with such low dosages (Normal members). Placebo is a hell of a drug lol.

 

[Shakez]

I ran 60mg a day for 100 days and noticed absolutely jack shit. Placebo is a hell of a drug.

 

[Ateam2023]

i ran 80 mg a day for 4 months , very slight improvement, it was a tested slupp so wasn't bunk,,

 

[human growth hormone]

i ran 80 mg a day for 4 months , very slight improvement, it was a tested slupp so wasn't bunk,,

people be running these random ass compounds, all u need is reta lol

 

[Ateam2023]

there was a big Slupp craze, summer of 2024, had to try the "latest fat burner" lol, it did increase cardio output and increased rhr, made cardio kinda "fun", everything returned to normal after stopping, cardio was no longer"fun" ahahaaaa,,, ymmv

 

[biggioman]

500mcg before fasted cardio, 500mcg before training

 

[Earthworm Jim]

That's good to know, I was going to buy some but not anymore. Now I'm looking at Albuterol

 

[hexagonal]

Bought 20mg pills because I let myself get hyped into it by people on various forums discussing it with bated breath.

Fuck all result. No improvement in cardio, no increased RHR (and EVERYTHING increases my RHR), no VO2 max increase, no faster weight loss, nothing.

 

[dcfreak]

I have been on it for 16 weeks. I had 4 bottles of the 250mcg and a few kits of injectable.

I have been averaging 2-3mg a day.

I would say that I feel I can tolerate cardio more. Not so much my actual output- just my tolerance for it if that makes any sense.

Very well could be placebo because thats about all its doing.

The relevant dose translates to something wild. I would probably grab some 50mg caps if they make them.

 

[cajunpauper]

What's most telling is that not a single pharma company, even the tiny kookie ones that engage in all sorts of long shot compounds. has expressed any interest in "exercise in a pill", which would be the next GLP blockbuster class of meds. That tells me it's been looked into and dismissed.

Having cycled on and off GLPs, I expected very little out of SLU. I have a pretty solid understanding of how I react to them, and what sort of weight loss to expect. It seemed that SLU behaved similarly to me as low dose clen, where an extra 1lb every few days was yielded without any other systemic changes to my regimen.

Very well could be psychosomatic, and I found a way to peel off that extra percent without knowing it. I don’t find it to be cost effective, irrespective of apparent efficacy, given an extra hour or two of cardio a week can be more easily integrated into my program as opposed to yet another compound in my body.

 

[chrysler]

Doesn't work for me. I get great results from Mots-C but this compound gives me no extra fat loss and no extra energy during exercise.

 

[krvuxn]

Anyone look into how ERRs can affect heart health, and also circadian rhythm? Preferably someone with an actual biology / medical education. I was doing some vibe researching with ChatGPT yesterday, and was looking into it - can anyone confirm? Basically seems like using it for too long can be bad for your heart, and using it too close to bed can potentially disrupt the circadian rhythm.

From ChatGPT regarding potential effects on sleep:

• ERRα/γ are involved in circadian rhythm regulation (they interact with BMAL1 and CLOCK).
• Theoretically: dosing too close to bedtime could alter circadian signalling → risk of lighter or fragmented sleep.

Regarding cardiac effects:

Potential Cardiac Risks of ERR Agonists

1. Energetic Overload / Arrhythmias

• ERRα/γ regulate oxidative phosphorylation, fatty-acid oxidation, and ATP production.
• Excess activation → increased mitochondrial demand and altered substrate use.
• In the heart, that can cause:
  • Electrical instability → arrhythmias (especially under stress/exercise).
  • Mismatch between oxygen supply and demand, raising ischemia risk in predisposed individuals.

2. Pathologic Hypertrophy

• ERRα is required for physiologic hypertrophy (exercise-induced).
• But chronic ERRα overactivation in animal models can mimic a persistent exercise-like program, which over time resembles pathologic hypertrophy (enlarged heart, stiffer walls).
• This is similar to what’s seen in endurance athletes’ hearts, but pharmacologically induced and potentially maladaptive.

3. Mitochondrial ROS & Damage

• More oxidative metabolism = more ROS production.
• If antioxidant systems don’t keep up, chronic ERR drive could promote oxidative stress, mitochondrial dysfunction, and eventually cardiomyopathy.

4. Interaction with Other Signals

• ERRs crosstalk with PGC-1α, AMPK, thyroid hormone, and estrogen receptors.
• In the heart, ERR agonism could destabilize the fine-tuned balance between glycolysis vs fatty-acid oxidation.
• That metabolic inflexibility is linked to heart failure progression in humans (where failing hearts can’t shift fuels properly)

5. Cancer-Like Proliferation Risks (indirect cardiac concern)

• ERRα/γ are upregulated in cancers to fuel high mitochondrial demand.
• In heart tissue, sustained ERR agonism might stimulate angiogenesis and growth pathways beyond what’s adaptive — potentially contributing to fibrosis or remodeling.

What’s Reassuring (in theory)

• ERRγ knockouts → severe cardiac defects (suggesting agonism supports heart function when balanced).
• Short-term ERR activation in animal models tends to improve mitochondrial efficiency and reduce lipid accumulation, which could be protective in obesity/diabetes.
• So the risks likely emerge with chronic, high-level, non-physiologic agonism — not short, transient use.

 

[atruse]

I just started dosing this at around 10mg fasted in the morning and it feels like I've taken clenbuterol (maybe it is lol)

just jumped into this dose arbitrarily since some people take 400mg, and some people take 500mcg, and I don't know what to believe

but i get the same "gitteryness" so i definitely notice it at this dose....

i do take it alongside reta and mots-c (been on both those 2 months)
and I will say that i have lost 4 lbs this week since starting.... (food intake and exercise remain the same)

 

[Shadiilac]

I ran SLU at 1mg every morning before fasted cardio and really can't tell if it did anything at all