SLU-PP-332 Dosing Confusion – Anyone Familiar with Receptor Activity / Best Practices?

[Matthex69]

Hey everyone,

I’ve been looking into SLU-PP-332 recently and noticed a huge discrepancy in dosing recommendations. Most fitness/biochem guys like Vigorous Steve suggest doses between 250 mcg and 1 mg max. But then you’ve got Chinese vendors selling 20 mg tablets, and a lot of users report feeling absolutely nothing at 1 mg only at much higher doses do they start to feel the real effects.

So what’s the deal here? Does anyone actually understand the mechanism of action, especially which receptors SLU-PP-332 activates ERRα and ERRγ and how that ties into effective dosing?

I’m also curious what the best timing strategy would be for taking it, and whether this compound needs to be cycled or if it can be taken continuously. Do you need to build up tolerance before it kicks in?

 

[Kralteramon]

That was actually a screenshot from a video ssa sent me as a disclaimer when I asked to order it. They said to be sure I was okay with the color before ordering. Watery pasta sauce or carrot juice definitely describes it well. For what it's worth, the 5 Amino 1MQ capsules I have contain an orange colored powder. I don't think the 20mg tabs are scored, but that's just a guess based on the fact that I have their 250mcg and 1000mcg tabs, and neither of those are. You'd hope they'd do it for the 20mg's, but ease of manufacturing probably means they won't be. Still, a good quality pill cutter should be able to split them fairly well.

Yeah i meant splitable with a pill splitter, sometimes they just crumble and turn into powder.

 

[hexagonal]

Well, that, and because taking 40-160x the dosage everybody else is taking, when the compound has absolutely no human safety data, ought to scare the hell out of you.

I found good deals on 20mg SLU-PP-332 caps and raws and was taking 20-40mg/day until I thought about it for a minute and realized I had just inadvertently donned a guinea pig suit and enrolled in the world’s worst run clinical trial.

20-40mg was giving me pretty good results, but in the end I decided it wasn’t doing anything I couldn’t achieve through better tested means less likely to make my wife a widow.

I am very excited about the future potential of exercise mimetics. I don’t expect they’ll be on the legitimate market in time for me to benefit, but the potential benefits to a population drowning in diabetes and metabolic syndrome and NAFLD are tremendous.

I'm skeptical that the 250mcg number was reached for any reason whatsoever besides "The Chinese UGLs threw a dart and decided that was a good level that met their profit targets"

There's certainly no studies they could have looked at to arrive at that dosing, because otherwise they would have been in the tens of mg range like we're seeing as options now.

People report good results from placebo all the time, so I'm super skeptical that 250mcg is doing anything for anyone.

But you're a guinea pig even at these low doses. We have no fucking idea what, if anything, this does in humans. 20mg seems to do nothing at all for me.

 

[Kralteramon]

I'm skeptical that the 250mcg number was reached for any reason whatsoever besides "The Chinese UGLs threw a dart and decided that was a good level that met their profit targets"

There's certainly no studies they could have looked at to arrive at that dosing, because otherwise they would have been in the tens of mg range like we're seeing as options now.

People report good results from placebo all the time, so I'm super skeptical that 250mcg is doing anything for anyone.

But you're a guinea pig even at these low doses. We have no fucking idea what, if anything, this does in humans. 20mg seems to do nothing at all for me.

Did you use the one from SSA?

 

[AnTabolic73]

Supposedly that's where 5 Amino 1MQ is really supposed to shine too, pre-contest or when you're at single digit bodyfat levels. I have some to try, but I'm easily over 10% at the moment, so it'll have to wait until I start a cut and get low. Have you tried injectable 5 Amino? I've heard it's bioavailability is greatly increased over the oral form, something like 5 fold was the number I recall being thrown around. I picked some of the 50mg up from a source here, and will be using that version. They warned me that it's a very bold orange color, but ensured me that the color had no negative effect on quality or purity. Oddly enough, they also told me their lower concentrations were "normal" (I assume clear?). Thankfully I'm pretty dark, so no concern about getting orange dots on my midsection lol
I also have some injectable slu-pp-332 inbound that I got before learning about it's terrible stability in liquid (see my above post), and plan to use that on addition to the SLU tabs. I'll be interested to hear what you're experience is with thr higher doses.

It's definitely.. Orange
View attachment 339657

Interesting. The tabs I got from them are orange. I assumed it was coloring to distinguish from other tablets.

 

[pewex]

Supposedly that's where 5 Amino 1MQ is really supposed to shine too, pre-contest or when you're at single digit bodyfat levels. I have some to try, but I'm easily over 10% at the moment, so it'll have to wait until I start a cut and get low. Have you tried injectable 5 Amino? I've heard it's bioavailability is greatly increased over the oral form, something like 5 fold was the number I recall being thrown around. I picked some of the 50mg up from a source here, and will be using that version. They warned me that it's a very bold orange color, but ensured me that the color had no negative effect on quality or purity. Oddly enough, they also told me their lower concentrations were "normal" (I assume clear?). Thankfully I'm pretty dark, so no concern about getting orange dots on my midsection lol
I also have some injectable slu-pp-332 inbound that I got before learning about it's terrible stability in liquid (see my above post), and plan to use that on addition to the SLU tabs. I'll be interested to hear what you're experience is with thr higher doses.

It's definitely.. Orange
View attachment 339657

No, I haven't tried the injectable version only 50mg tabs. That's why I'll be using 150mg this time, since I've read that oral doses typically require 100-150mg. Maybe that's why I didn't notice much, or maybe it's just overhyped (or I'm a non-responder), same as with SLU.

I'll be running 2-3mg/day of SLU too. I'm not going any higher, they even sell 20mg tabs, but with limited research, I'm not trying to be the next Bostin Loyd and fry my kidneys on some research chem. I'll leave the heavy experimenting to others.

 

[verylargeshoes]

I'm skeptical that the 250mcg number was reached for any reason whatsoever besides "The Chinese UGLs threw a dart and decided that was a good level that met their profit targets"

Absolutely agreed. That dosage may as well have popped out of a random number generator, which is also true for 20mg. It is, however, the dose that most people are taking and for which we have the most anecdata. The problem for me is that when I’m out on the edge of the population’s dosage range, I’m much more likely to be the lucky fella that discovers the fatal dose-dependent side effect. I’m just not feeling that team-spirited about this compound. I’ve got 2.5 kids to raise, a mortgage to pay, and a few items left on my bucket list.

I already did my pharma pioneering civic duty with a relatively new autoimmune medication a couple of years ago. I was surprised to discover that when I take it, I develop a rare blood cancer. This was not a documented risk with this medication, which is one of the main reasons I selected it. Thankfully, when I stopped taking it, the cancer appeared to go into remission. So far!

So I’ll stick with the stuff that is either well tested at the dosages I’m taking, or which is absolutely necessary to achieve my goals and has no safer / better understood substitute. I just don’t see how SLU-PP-332 is irreplaceable for any goals I have, or really any common bodybuilding goal.

But to each their own poison! I wish everybody luck with it. I guess all the real hardcore guinea pigs are moving on to BAM15 now, anyway.

 

[hexagonal]

Did you use the one from SSA?

Yep. I've not had it independently tested, but I've had generally solid results with SSA stuff in general. I won't be ordering any more after my current supply runs out.

Absolutely agreed. That dosage may as well have popped out of a random number generator, which is also true for 20mg. It is, however, the dose that most people are taking and for which we have the most anecdata. The problem for me is that when I’m out on the edge of the population’s dosage range, I’m much more likely to be the lucky fella that discovers the fatal dose-dependent side effect. I’m just not feeling that team-spirited about this compound. I’ve got 2.5 kids to raise, a mortgage to pay, and a few items left on my bucket list.

I already did my pharma pioneering civic duty with a relatively new autoimmune medication a couple of years ago. I was surprised to discover that when I take it, I develop a rare blood cancer. This was not a documented risk with this medication, which is one of the main reasons I selected it. Thankfully, when I stopped taking it, the cancer appeared to go into remission. So far!

So I’ll stick with the stuff that is either well tested at the dosages I’m taking, or which is absolutely necessary to achieve my goals and has no safer / better understood substitute. I just don’t see how SLU-PP-332 is irreplaceable for any goals I have, or really any common bodybuilding goal.

But to each their own poison! I wish everybody luck with it. I guess all the real hardcore guinea pigs are moving on to BAM15 now, anyway.

Yeah, I don't think I'd take any of these totally-untested-on-humans compounds if I had kids.

Sorry to hear about the cancer, glad it looks to be in remission, hope it stays that way!

 

[GabrielAc]

I don't feel shit at the moment at 50/70mg 3x a day but I just started so who knows

Hey! Any feedback on this dosage? Did you felt anything at all?