Blood Pressure

[BP_6]

Seems there's no way to add "Cilniheal" to cart on healingpharmaonline. They ship to the USA?

Go to PCT24/7 and get a list. He is the man when it comes to Indian pharmacy products.

 

[explodingHeart]

Go to PCT24/7 and get a list. He is the man when it comes to Indian pharmacy products.

1000 pills of 20mg Cilnidipine would cost $400 from him.

@Ghoul was talking about another pharm.

 

[Ghoul]

1000 pills of 20mg Cilnidipine would cost $400 from him.

@Ghoul was talking about another pharm.

We can't discuss specific sources outside the Underground, which is why I kept it general.

I love vendors here but when you're talking about wholesale type quantities, 1000+ tabs of anything. you should ignore price lists and email for a quote, and probobly shop around a little bit. Could keep hundreds in your pocket.

 

[Bumpygooch]

BP back to 140/75, even with the additional 10mg(20 total) cilnidipine. Have some HCTZ en route from PCT. In the interim, I have some spiranalactone and furosemide available, as I believe a light diuretic is next in the treatment . Obviously the latter isn’t as light as the former.

 

[Ghoul]

Folks, BP meds typically take 4 weeks of stable daily doses to reach maximum reduction after initiating or titrating the medication.

Cilnidipine (and most BP meds generally):

After first dose: 20%
After 1 Week: 50%
After 2 Weeks: 70%
After 4 Weeks: 100%

Declaring failure after a few days is premature, and quickly making changes can fuck you up if you're not allowing things to stabilize.

 

[explodingHeart]

Folks, BP meds typically take 4 weeks of stable daily doses to reach maximum reduction after initiating or titrating the medication.

Cilnidipine (and most BP meds generally):

After first dose: 20%
After 1 Week: 50%
After 2 Weeks: 70%
After 4 Weeks: 100%

Declaring failure after a few days is premature, and quickly making changes can fuck you up if you're not allowing things to stabilize.

Tips for long international flights to avoid clotting up/stroke? Keep HCT low? Any pharma you would take?

 

[Bumpygooch]

Folks, BP meds typically take 4 weeks of stable daily doses to reach maximum reduction after initiating or titrating the medication.

Cilnidipine (and most BP meds generally):

After first dose: 20%
After 1 Week: 50%
After 2 Weeks: 70%
After 4 Weeks: 100%

Declaring failure after a few days is premature, and quickly making changes can fuck you up if you're not allowing things to stabilize.

Fair enough, I’ll stay the course. But, the immediate success followed by a return to the condition which caused the change to begin with is concerning.

 

[Ghoul]

Tips for long international flights to avoid clotting up/stroke? Keep HCT low? Any pharma you would take?

Are you at known high risk, ie, had clots before? If so this doesn't apply and you need something even stronger than these. Otherwise, they are much better than the usual asprin:

Apixaban 5 mg or Rivaroxaban 10mg, once just before flight

Non-pharma option: spring for business class on a (NON-US) carrier that offers suites like my favorite for Asia, ANA's "The Room":

 

[Ghoul]

Fair enough, I’ll stay the course. But, the immediate success followed by a return to the condition which caused the change to begin with is concerning.

Understandable.

It's not really made clear in the PED community. Consider that when prescribed to normies, it's typically done at one appt and BP isn't checked again for a month or more, then adjustments are made and another month goes by.

Hell, most people don't even have a BP cuff at home, even those with hypertension.

 

[explodingHeart]

Are you at known high risk, ie, had clots before? If so this doesn't apply and you need something even stronger than these. Otherwise, they are much better than the usual asprin:

Apixaban 5 mg or Rivaroxaban 10mg, once just before flight

Non-pharma option: spring for business class on a (NON-US) carrier that offers suites like my favorite for Asia, ANA's "The Room":

View attachment 339535

I have Prothrombin G20210A mutation (Factor II mutation) heterogeneous which 2-3x my chances of a DVT. I did a timed clotting lab test and it was slightly below average range.

 

[Ghoul]

I have Prothrombin G20210A mutation (Factor II mutation) heterogeneous which 2-3x my chances of a DVT. I did a timed clotting lab test and it was slightly below average range.

The safest thing is going to a doctor for a pre-trip Enoxaparin injection.

If you're committed to doing it DIY, the two tabs I mentioned are commonly used off label by seasoned travelers, even those at relatively high risk.

 

[john87412]

Tips for long international flights to avoid clotting up/stroke? Keep HCT low? Any pharma you would take?

L-Citrulline at doses higher than 6g reduces hct and BP. Amlodipine at 5mg also reduces hct but has nasty side effects.

 

[BamaCrazy]

L-Citrulline at doses higher than 6g reduces hct and BP. Amlodipine at 5mg also reduces hct but has nasty side effects.

I found a study that confirms Citrulline can reduce BP. But was unable to find anything to backup the claim it reduces HCT. Where did you find that data?

 

[malfeasance]

I started with 10/40 as separate tablets. Since 4 weeks in I wasn't hitting target of 115 SBP, I decided to try increasing Ciln first (normally you'd increase the ARB first, not the CCB). It worked out great, providing the additional 5 points of SBP reduction I needed, but it was the down-regulation of adrenaline driven sympathetic nervous system effects via n-channel blocking that's most impressive. If you're the "high adrenal tone" phenotype (50-60% of Northern Europeans thanks to the Vikings) subtly life changing is no exaggeration. Anyway, at that point I was able to commit to buying a 4 year supply of 20/40 tabs for a great wholesale price.

This is sounding more and more like it is going to interfere with becoming a Berserker, which is a life goal.

 

[Ateam2023]

L-Citrulline at doses higher than 6g reduces hct and BP. Amlodipine at 5mg also reduces hct but has nasty side effects.

could you please link that study to bph/
hct being lowered by high doses of l citrulline that would be awesome, i cant find supportive on the hct as other members have stated,, tia

 

[Ateam2023]

L-Citrulline at doses higher than 6g reduces hct and BP. Amlodipine at 5mg also reduces hct but has nasty side effects.

high doses of l citrulline are known to enhance nitric oxide mediated vascular function , "Lowering BP" and aiding in excercise recovery, up to 10 grams , web md, nih, are good examples, "but nothing" supports hct lowering, is this something you noticed on personal bloodwork? tia

 

[The Answ3r]

Didn’t even know l-citrulline lowers blood pressure, but man… 8g of that plus 5mg Cialis before a workout? The pump is insane, veins popping so hard people at the gym probably think I’m on gear.

 

[Mick]

I prefer to reduce pill count where possible. I think there are not only practical but subtle psychological benefits.

TLDR yes the fact the combo is cheaper than Ciln alone makes it a no brainer imo.

The deeper rationale follows (warning: over analysis psychosis below lol).

Usually better to start separate because if dose isn't dialed in, you risk getting stuck with combo meds you can't use.

In this case though, both are at starting doses, so if any adjustment would be needed, you're really only going up from here (by adding 10 Ciln or 40 Telm), so "Going to waste" is unlikely.

I started with 10/40 as separate tablets. Since 4 weeks in I wasn't hitting target of 115 SBP, I decided to try increasing Ciln first (normally you'd increase the ARB first, not the CCB). It worked out great, providing the additional 5 points of SBP reduction I needed, but it was the down-regulation of adrenaline driven sympathetic nervous system effects via n-channel blocking that's most impressive. If you're the "high adrenal tone" phenotype (50-60% of Northern Europeans thanks to the Vikings) subtly life changing is no exaggeration. Anyway, at that point I was able to commit to buying a 4 year supply of 20/40 tabs for a great wholesale price.

Given how it's cured my longstanding Reynaud's symptoms, and the great "feel" of reduced sympathetic drive, I'm concerned about loss of access to Ciln lowering my quality of life, so building a significant buffer supply was something important to me.

I even grabbed 1k of Ciln 20 tabs from the same vendor, since adding it on was very cheap, just in case I need to drop the Telm at some point and can't use the combo. That's unlikely though, my BP is very stable as I'm maxed out on cardio induced reduction, and at ideal weight already.

You cured your raynauds. I have had this since like 23. Hate it. Any abrupt change in temp fingers go white. Mostly only affect my hands. Brutal in the winter. If I get really cold it will get my feet also. High stress will kick it in sometimes too. But mainly going from hot to cold quickly blood supply shuts right down to my finger tips. How did you fix this?? Really interested. How long did it take?

 

[Ghoul]

You cured your raynauds. I have had this since like 23. Hate it. Any abrupt change in temp fingers go white. Mostly only affect my hands. Brutal in the winter. If I get really cold it will get my feet also. High stress will kick it in sometimes too. But mainly going from hot to cold quickly blood supply shuts right down to my finger tips. How did you fix this?? Really interested. How long did it take?

About AISA-021 – Aisa Pharma, Inc.

More than 27 million Americans suffer from Raynaud’s and yet no drug is specifically approved for the treatment of Raynaud’s disease in the United States.

aisapharma.com

To be clear, it's not genuinely a "cure", since it doesn't permanently fix it, but it did eliminate all symptoms for me. BP wasn't ideal and have to take something for it anyway, so it worked out perfectly.

Affected a couple of toes on each foot for me. Started about 10 years ago.

After the first month at 10mg I noticed symptoms seemed much better, but I wasn't certain. By the end of the 2nd month it was obvious things were improved immensely. Only the slightest cold induced symptoms.

A month after I increased to 20mg it was over. No symptoms whatsoever.

Full disclosure, I'm also using daily low dose tadalafil, which Ciln is combined with in the Reynauds treatment trial.

Trials Underway for New Raynaud's Drug - Raynaud's Association

Exciting news for Frosties: A clinical study is underway for a new Raynaud’s drug that could be the first FDA-approved drug specifically for Raynaud’s.

www.raynauds.org

(besides the pumps, LD tadalafil a great longevity drug that lowers all cause mortality, and especially the risk of heart attack or stroke. It's even FDA approved for this purpose. Sides are minor, if any, minor nose congestion is most common, and resolve within a month for the vast majority).

Spy pic of dangerous investigational drug Cilnidipine, kept safely away from the public in a secure lab in Boston, MA.

 

[john87412]

high doses of l citrulline are known to enhance nitric oxide mediated vascular function , "Lowering BP" and aiding in excercise recovery, up to 10 grams , web md, nih, are good examples, "but nothing" supports hct lowering, is this something you noticed on personal bloodwork? tia

l-Citrulline Supplementation: Impact on Cardiometabolic Health - PMC

Diminished bioavailability of nitric oxide (NO), the gaseous signaling molecule involved in the regulation of numerous vital biological functions, contributes to the development and progression of multiple age- and lifestyle-related diseases. While ...

pmc.ncbi.nlm.nih.gov

It more so can keep hct stable and prevent it from increasing.