In my own experience keeping primo around 200-250 just for E2 control works perfect, 300-400mg is borderline but at 500mg and higher it freaking nukes my lipids. The hardest impact on my lipids had mast, even at 100-150mg a week it totally fucked my lipids, ldl went through the ceiling.
Now sitting at 250mg of primo a week and got ezemtibe + bempoic acid and my lipids look really good
High Test high DHT for a cycle defo works but i wouldnt run it long term, i'd always would opt for the idea of running the lowest amount of primo needed to keep E2 in check unless you are blessed by the genetic gods for lipids