Help brewing L carnitine

[MarkusLA]

So I got everything and I'm gonna make some carnitine. Should I heat it or is room temp fine? some people say heat others say room temp is ok. Also, of it stings what should I add to increase ph? is baking soda good? or are NaOh pellets better? Not that I mind the PIP but I wanna use it daily long term so less PIP would be nice

From what I understand of reading many other threads, which you should do also... Yes, heat the water to 50c. The sterilizing occurs during filtration. I would still clean the equipment with boiling water. pH of pharma carnitine uses HCL to drop pH to 6.2.

 

[tweek]

So I got everything and I'm gonna make some carnitine. Should I heat it or is room temp fine? some people say heat others say room temp is ok. Also, of it stings what should I add to increase ph? is baking soda good? or are NaOh pellets better? Not that I mind the PIP but I wanna use it daily long term so less PIP would be nice

Are you using ba? If you are then it will mix better with the sterile water being warm, not hot.

Mixing it with cold or room temperature can make it cloudy and not want to mix properly

 

[Luke391]

From what I understand of reading many other threads, which you should do also... Yes, heat the water to 50c. The sterilizing occurs during filtration. I would still clean the equipment with boiling water. pH of pharma carnitine uses HCL to drop pH to 6.2.

well fuck I was eager to make it and didn't. I used gloves and tried to keep it clean. hopefully it will still be good

 

[Luke391]

Are you using ba? If you are then it will mix better with the sterile water being warm, not hot.

Mixing it with cold or room temperature can make it cloudy and not want to mix properly

I was eager to make it and didn't wait for you guys' advice, my bad. it mixed fine. tommorow I'll try it. I hope it will be fine

 

[Charlesthefirst]

Here to find this out as well

 

[Spaceman Spiff]

Here to find this out as well

Find out what?

 

[Charlesthefirst]

adding HCL. im brand new to this but wanted to learn about brewinig L Carn

 

[hytereserach]

I did a brew recently. No additions. Just water, carnitine base, and BA. I tested the pH after the fact (I always brew ~10ml more than I need), and it was very close to 6.7 (I think I read this was pharma pH). There was no need for HCl, and I had no PIP or anything.

 

[ianbak]

I brew at 500mg/ml . Final PH is usually 8ish . I adjust to 7 using small amount of L Carnitine HCL solution.
I have been playing with Acetyl L Carnitine HCL . Adding small amounts (50 to 100mg per ml) seems to give a neurological boost during workouts. PH adjustment is a challenge though.

 

[Rakusa]

I brew at 500mg/ml . Final PH is usually 8ish . I adjust to 7 using small amount of L Carnitine HCL solution.
I have been playing with Acetyl L Carnitine HCL . Adding small amounts (50 to 100mg per ml) seems to give a neurological boost during workouts. PH adjustment is a challenge though.

what's your ph buffering agent? NaOH? If yes, how much do you add per 100ml? ca?

 

[ianbak]

what's your ph buffering agent? NaOH? If yes, how much do you add per 100ml? ca?

For L Carnitine I adjust PH using L Carnitine HCL. It seems to stay very stable after that - no degradation and PH shifting like Glutathione.

ALCAR HCL is very acidic . I made the first batch with NaOH PH adjustment but I am not happy with it. I had to use too much of NaOH. I am going to try sodium bicarbonate to neutralize ALCAR HCL to base form in next batch. This will have added advantage of having some bicarbonate in solution as PH buffer. I will post update once I have it. ALCAR has more neurological benefits than muscle.

 

[LGOP528]

For L Carnitine I adjust PH using L Carnitine HCL. It seems to stay very stable after that - no degradation and PH shifting like Glutathione.

ALCAR HCL is very acidic . I made the first batch with NaOH PH adjustment but I am not happy with it. I had to use too much of NaOH. I am going to try sodium bicarbonate to neutralize ALCAR HCL to base form in next batch. This will have added advantage of having some bicarbonate in solution as PH buffer. I will post update once I have it. ALCAR has more neurological benefits than muscle.

You will need about twice the sodium bicarbonate to adjust the PH compared to NaOH.

 

[ianbak]

You will need about twice the sodium bicarbonate to adjust the PH compared to NaOH.

Yes but
1. Most of it will react and convert into Salt and CO2. While most of NaOH lingers around in the body until neutralized.
2. Sodium Bicarbonate is used in medical settings in injectable form. So if a small amount gets into the body it should be safe.
3. It acts as weak buffer with CO2

 

[LGOP528]

Yes but
1. Most of it will react and convert into Salt and CO2. While most of NaOH lingers around in the body until neutralized.
2. Sodium Bicarbonate is used in medical settings in injectable form. So if a small amount gets into the body it should be safe.
3. It acts as weak buffer with CO2

1) Your complaint was about the amount of NaOH you had to use.

2) NaOH is also used in medical settings. This is because all the NaOH is consumed in the reaction, if it wasn’t the PH would be very high. I am not sure what you are talking about NaOH lingering in the body?

3) Yes, it can act as a buffer but I do not think it outweighs the other benefits of NaOH. I have made several batches of different compounds. All have lasted 30 days and needed no buffer.

4) I think people gravitate towards sodium bicarbonate because NaOH is intimidating. There is nothing wrong with this approach, just admit it.

 

[ianbak]

1) Your complaint was about the amount of NaOH you had to use.

2) NaOH is also used in medical settings. This is because all the NaOH is consumed in the reaction, if it wasn’t the PH would be very high. I am not sure what you are talking about NaOH lingering in the body?

3) Yes, it can act as a buffer but I do not think it outweighs the other benefits of NaOH. I have made several batches of different compounds. All have lasted 30 days and needed no buffer.

4) I think people gravitate towards sodium bicarbonate because NaOH is intimidating. There is nothing wrong with this approach, just admit it.

You make some good points except NaOH is not consumed in the reaction. It stays intact and might get separated once injected. While most of sodium bicarbonate reacts and changes form.

End product with sodium bicarbonate had very stable PH curve around 6 to 8. You can easily dial in PH of 7 and use it subq - no PIP.

There is no one right way of making this. I am sure you can use phosphate buffers to dial in PH.

 

[LGOP528]

You make some good points except NaOH is not consumed in the reaction. It stays intact and might get separated once injected.

Can you explain how NaOH is not consumed in the reaction as long as the PH is below 7?

There is no one right way of making this. I am sure you can use phosphate buffers to dial in PH.

I agree, there are different approaches to this and as long as you end up with a sterile solution and the right PH, I don’t think it really matters.

Edit: I needed to clarify the target PH level.

 

[ianbak]

Can you explain how NaOH is not consumed in the reaction as long as the PH is below 7?


I agree, there are different approaches to this and as long as you end up with a sterile solution and the right PH, I don’t think it really matters.

Edit: I needed to clarify the target PH level.

I have both OH and bicarbonate variants now. I will try both and report back.

I am leaning back towards NaOH after your push back and looking at data.

Thanks

 

[LGOP528]

I have both OH and bicarbonate variants now. I will try both and report back.

I am leaning back towards NaOH after your push back and looking at data.

Thanks

No problem! I am going to get some ALCAR HCL after looking into it because of your post.


Add the NaOH very slowly and let the PH and heat settle before you add more.

 

[ianbak]

No problem! I am going to get some ALCAR HCL after looking into it because of your post.


Add the NaOH very slowly and let the PH and heat settle before you add more.

That’s what I did with first batch. I think I was bit too aggressive with dialing in exact PH of 7-7.4 .

I should stop mid around mid 6 . For more precise PH starting with phosphates buffer solution is better choice.

 

[Rakusa]

Guys can someone help me out with my little brew? I brewed my l-carnitine at around 500mg/ml, but this time I get fucking pip for a couple of days. Like really bad. I thought l-carnitine auto adapts its PH? what could have went wrong? Any idea on how to fix the issue?