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97 THE ABSORPTION KINETICS OF SUBCUTANEOUSLY ADMINISTERED GRWOTH HORMONE: INFLUENCE OF INJECTION VOLUME - Pediatric Research
Daily subcutaneous (sc) injections (inj) seems now to be the recommended mode of GH administration. A substantial sc degradation of exogenous GH has previously been reported. The aim of the present study was to evaluate the influence of inj volume on the sc absorption rate and bioavailability of...
www.nature.com
This says the opposite then @Ghoul ?97 THE ABSORPTION KINETICS OF SUBCUTANEOUSLY ADMINISTERED GRWOTH HORMONE: INFLUENCE OF INJECTION VOLUME - Pediatric Research
Daily subcutaneous (sc) injections (inj) seems now to be the recommended mode of GH administration. A substantial sc degradation of exogenous GH has previously been reported. The aim of the present study was to evaluate the influence of inj volume on the sc absorption rate and bioavailability of...
Im wondering cause I increased my dose recently but lowered to 1ml. Now im wondering if I should just stick to 2ml and inject more water. Im taking 2iu so it might not be huge difference too.
Ghoul
Member
97 THE ABSORPTION KINETICS OF SUBCUTANEOUSLY ADMINISTERED GRWOTH HORMONE: INFLUENCE OF INJECTION VOLUME - Pediatric Research
Daily subcutaneous (sc) injections (inj) seems now to be the recommended mode of GH administration. A substantial sc degradation of exogenous GH has previously been reported. The aim of the present study was to evaluate the influence of inj volume on the sc absorption rate and bioavailability of...
Look at the numbers more carefully. Not the narrative. The numbers.
Ghoul
Member
Don't inject subQ with 2ml. With some exceptions, 1ml is considered the limit, and .8ml or lower is preferable.
There's a reason why that study shows faster absorption (and a higher peak) with 2ml, but it's not obvious. Absorption still slows using a higher volume for the same dose, with realistic injection volumes.
But really, for 2iu, I doubt you'd get a side effect inducing GH peak no matter how you administered it. Personally I wouldn't want less than .2ml for any dose (of anything) just because it's pain in the ass to go lower than that and be accurate. .1ml per iu makes the math easy too. Easy unless you're using 36iu+ vials. If you get sides at that dose it's probobly something other than the peak causing it. Like liver or kidney problems.
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Spaceman Spiff
Subscriber
All of this talk of the concentration and what of the HGH seems ridiculous.
Went from quoting pharma to fit the agenda, when realized serostim could use a higher concentration, now the reference point changes to "older pharma". i mixed 0.55ml per 12iu just fine
18iu per 0.5ml for Serostim lol.
doesnt geno use 36iu per ml?
OP Does your family have any blood flow issues? specifically to your legs?
how old are you? any history of heart issues?
Went from quoting pharma to fit the agenda, when realized serostim could use a higher concentration, now the reference point changes to "older pharma". i mixed 0.55ml per 12iu just fine
18iu per 0.5ml for Serostim lol.
doesnt geno use 36iu per ml?
OP Does your family have any blood flow issues? specifically to your legs?
how old are you? any history of heart issues?
Sorry for the confusion. Im using 10iu vials so thats the total volume. Injection is either .2ml or .4ml for the 1ml or 2ml
TurboJet
Member
Quit taking it? Most people don't need growth they need discipline.
90+% of people taking it aren't even at the point of needing to achieve gains.
I haven't seen your stats but there's so many posters that are 165-185 lbs sitting at 20+%bf wondering why they aren't Arnold reincarnate running growth. It's called discipline and patience.
Same with the heavy guys, more drugs ain't going to fix a bad diet and lack of discipline.
Yeah yeah.... The fat shots are making it easier yadda yadda.
Addiction and dependency are real.
Sorry rant off.
29trt
Member
Holy feck did I miss it or nobody mentioned what PEDs is he on....your pedantic nonsense, ghoul, about concentrations makes exactly zero difference to anyone or anything except maybe local inflammation after the shot....give it a break.
Again what stack ar you on?
deca is known to wreck people( does it to me too) when on GH you gain tons of weight in a couple of weeks and than it spills over and you get edema.
Something with the aldosterone that makes this happen
Anyway.....
Again what stack ar you on?
deca is known to wreck people( does it to me too) when on GH you gain tons of weight in a couple of weeks and than it spills over and you get edema.
Something with the aldosterone that makes this happen
Anyway.....
Spaceman Spiff
Subscriber
Agreed
This is the problem when people diagnose their own shit with online information rather than using common sense.
Occams razor. JFC
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Ghoul
Member
The excipient formulation was developed to create a similar absorption rate to older, low concentration somatropin. No one knows what the excipients are in any particular batch of UGL.
The phosphates control PH at the injection site. which condition tissues to absorb at a consistant rate.
The mannitol draws water into the injection depot, slowing absorption.
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-van der Laan et al., 1999 (Pharmaceutical Research)
Influence of excipients on subcutaneous injection depot and absorption kinetics of peptides.
“Formulations containing mannitol caused increased interstitial fluid accumulation at the injection site due to its osmotic properties, resulting in a larger depot volume. This enlargement leads to a slower release and prolonged absorption of the peptide.”
⸻
-Marxan et al., 2014 (Journal of Controlled Release)
Impact of formulation excipients on peptide drug absorption.
“Mannitol, as an osmotic agent, modulates the microenvironment by drawing water into the depot, thereby increasing local fluid volume and reducing the concentration gradient driving absorption. This results in a delayed absorption profile.”
⸻
Pfeiffer et al., 2012 (European Journal of Pharmaceutics and Biopharmaceutics)
Effect of excipients on subcutaneous injection site physiology and drug bioavailability.
“The presence of mannitol elevates osmotic pressure at the injection site, promoting water influx that dilutes the drug and expands the depot. This effect slows diffusion into systemic circulation and can extend the absorption phase of protein therapeutics.”
Spaceman Spiff
Subscriber
I honestly give 0 fucks what you have to say.
Half the shit you say miss the point because you lack an original thought or it's pointless.
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Ghoul
Member
I'm not posting it for you.
I don't judge myself by the opinion a low life drug dealer with weak opsec and an even weaker mind.
Spaceman Spiff
Subscriber
A lowlife drug dealer that put more money toward data collection for harm reduction than you ever have. You don't even match up to 1%
Clearly you posted it for me. Lol. It was a quote dillhole
Ghoul
Member
Spaceman Spiff
Subscriber
Spaceman Spiff
Subscriber
Also let's be real. How many "low life drug dealers" post this much to testing for everyone to see and not just that. See the original source?
You really lack real world experiences. Just some guy hiding from the real world, no clinical knowledge, and try to figure the world out from behind his keyboard
Keep trying to throw insults at me and you do not even understand the big picture
People like you rely on people like me to try to remotely ensure your safety.
ROFL
You really lack real world experiences. Just some guy hiding from the real world, no clinical knowledge, and try to figure the world out from behind his keyboard
Keep trying to throw insults at me and you do not even understand the big picture
People like you rely on people like me to try to remotely ensure your safety.
ROFL
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Ghoul
Member
I gave you a hint. Next time read to comprehend.
The study concluded that "LARGE", not "LARGER" injections=faster absorption.
16.9 ng/ml (0.5 ml)
14.7 ng/ml (1 ml)
23.7 ng/ml (2 ml)
1ml has a SLOWER ABSORPTION rate than .5ml.
Is 1ml larger then .5ml? Yes. Does it absorb more slowly? Yes.
2ml subQ injections shove so much liquid into a small space it creates high pressure bubbles forcing the drug into blood vessels, and it's why huge subQ injections are rarely used.
