I’d expect 6.75 mg/week should be way more than enough to give most people a taste of whatever side effects (and primary ones) they’re going to get. I had RHR and allodynia (strange skin sensations) at my starting dose of 1-2 mg/week.
Reta’s not the best at hunger suppression, so that’s probably the weakest signal of effect and quality. It’s is so much less potent than tirzepatide for appetite control, I have to combine it with cagrilintide (10mg Reta, 1 mg cagri). 10mg Reta every 5 days seems like it might be a bit to much for me, as I’ve been having my first real GI symptoms from it — chronic hiccuping for a week+, nausea, abdominal discomfort.