Pharma Trizepetide Vs Generic

[fw190jd]

Greetings ,

I just finished 2 months of pharma Tirz, fist month not much action at 2.5mg, second month things started popping a little a 5mg, some minor side effects , but we perservered. The price increases with dosage increases with my provider, so I wanted to try a more cost effective approach, I purchased some from my peptide supplier with a Jano report and went up to my next level of 7.5mg, been a week , I would say the food noise is gone, the weight has stopped coming off , I was starting to average 1.5 pounds a week, now I'm heading in the other direction, 2 pounds in a couple of days water weight. I have a tendency to under hydrate.
I always overthink this shit and try to hard, any thoughts ? suck it up and go back to the pharma ?
Looking forward to sme great thoughts as usual, thanks in advance for your help.

 

[Ghoul]

Does the 0.5ml per whatever dose you're using apply only to Tirz, or would it also apply to other GLP1's, specifically Reta? What is the reason for the concentration being an important factor, something related to dispersion time of the bolus? I've been reconstituting my Tirz and Reta at ~ 20iu/whatever my current dose is ratio. I've got hundreds of 0.3ml syringes, guess I need to be buying the 0.5's from now on.

It's related to the pharmacokinetics. At the same peptide concentration, uptake time increase with volume. Lower the volume, uptake speeds up, which can worsen side effects. .5ml / dose is used for Sema, Tirz, and Reta. Except 1.7mg or larger doses of Sema, which are .75ml. Presumably they do this to slow those large doses down given how potent Sema sides can be, and/or the risk of a spike causing brief hypoglycemia.

If you're not having any issues at .3ml I'm not suggesting you have to change. We're simply discussing what's ideal, and a good starting point for new users.

The other reason is that higher peptide concentrations lead to faster aggregation.

When peptide monomers bump into each other more frequently, they stick together more often forming aggregates, At the least this wastes peptides, as aggregates won't be bioactive (at least not the way you want them to be), and at worst there are other, primarily immunogenicity concerns, but not a topic I'm going to rehash yet again.

My policy is to reconstitute with enough bac to replicate pharma volume, or if there isn't a pharma (or human study) equivalent, 3.5ml as long as the volume doesn't exceed .75ml for my required dose. Overdiluting never harms a peptide, and the only potential negative would be slowing uptake of the dose, which I've never found to be problem.

 

[OldGHGuy]

It's related to the pharmacokinetics. At the same peptide concentration, uptake time increase with volume. Lower the volume, uptake speeds up, which can worsen side effects. .5ml / dose is used for Sema, Tirz, and Reta. Except 1.7mg or larger doses of Sema, which are .75ml. Presumably they do this to slow those large doses down given how potent Sema sides can be, and/or the risk of a spike causing brief hypoglycemia.

If you're not having any issues at .3ml I'm not suggesting you have to change. We're simply discussing what's ideal, and a good starting point for new users.

The other reason is that higher peptide concentrations lead to faster aggregation.

When peptide monomers bump into each other more frequently, they stick together more often forming aggregates, At the least this wastes peptides, as aggregates won't be bioactive (at least not the way you want them to be), and at worst there are other, primarily immunogenicity concerns, but not a topic I'm going to rehash yet again.

My policy is to reconstitute with enough bac to replicate pharma volume, or if there isn't a pharma (or human study) equivalent, 3.5ml as long as the volume doesn't exceed .75ml for my required dose. Overdiluting never harms a peptide, and the only potential negative would be slowing uptake of the dose, which I've never found to be problem.

@Ghoul You may have covered this but for a single 10mg vial of Tirz, for a single 10mg dose, can 0.5ml reconstitute or do I need 1.0ml? Also, does jumping from 5mg to 10mg make sense our would you recommend an interim step to 7.5mg first?

 

[Ghoul]

@Ghoul You may have covered this but for a single 10mg vial of Tirz, for a single 10mg dose, can 0.5ml reconstitute or do I need 1.0ml? Also, does jumping from 5mg to 10mg make sense our would you recommend an interim step to 7.5mg first?

Yes .5ml for a 10mg vial used as a single dose is fine. It's matches Eli Lily's tirz per dose volume, for all doses, including the upcoming 20 and 25mg pens.

 

[OldGHGuy]

Yes .5ml for a 10mg vial used as a single dose is fine. It's matches Eli Lily's tirz per dose volume, for all doses, including the upcoming 20 and 25mg pens.

Great. Thanks again. 7.5 or go right to 10 in your experience?

 

[Ghoul]

Great. Thanks again. 7.5 or go right to 10 in your experience?

What's your GLP history?

 

[OldGHGuy]

What's your GLP history?

I'm happy staying at 5mg.

My wife:
2.5 for 4 weeks
5.0 for 4 weeks

All tolerated well

 

[Ghoul]

I'm happy staying at 5mg.

My wife:
2.5 for 4 weeks
5.0 for 4 weeks

All tolerated well

May as well stick with the proven pharma protocol. 7.5mg has a noticeable bump in effect over 5. If after the second dose all is well and more appetite suppression would be welcome, then you could jump to 10.

You could reconstitute with .6ml, use .45ml for a 7.5mg dose.

If you want to conserve the Tirz rather than tossing the excess, do the same with next two vials. Then combine the remaining .15ml in each of the 3 vials for the fourth dose of 7.5mg.

 

[OldGHGuy]

May as well stick with the proven pharma protocol. 7.5mg has a noticeable bump in effect over 5. If after the second dose all is well and more appetite suppression would be welcome, then you could jump to 10.

You could reconstitute with .6ml, use .45ml for a 7.5mg dose.

If you want to conserve the Tirz rather than tossing the excess, do the same with next two vials. Then combine the remaining .15ml in each of the 3 vials for the fourth dose of 7.5mg.

As always, excellent advice!